Low‐level light stimulates excisional wound healing in mice

Demidova-Rice, Tatiana N.; Salomatina, Elena; Yaroslavsky, Anna N.; Herman, Ira M.; Hamblin, Michael R.

doi:10.1002/lsm.20549

Cited by 152 publications

(120 citation statements)

References 46 publications

(43 reference statements)

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“…Some of the animal studies investigating the effects of LLLT on wound healing have found similar results to the ones found in the in vitro studies, ranging from decreased inflammation and increased collagen and granulation tissue in the wound bed to increased tensile strength and faster epithelization [20][21][22][23].…”

Section: Lllt-mechanism Of Action On Cellular and Tissular Levelsupporting

confidence: 64%

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

et al. 2016

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Breast cancer is the most common cancer in women worldwide, with an incidence of 1.7 million in 2012. Breast cancer and its treatments can bring along serious side effects such as fatigue, skin toxicity, lymphedema, pain, nausea, etc. These can substantially affect the patients' quality of life. Therefore, supportive care for breast cancer patients is an essential mainstay in the treatment. Low-level light therapy (LLLT) also named photobiomodulation therapy (PBMT) has proven its efficiency in general medicine for already more than 40 years. It is a noninvasive treatment option used to stimulate wound healing and reduce inflammation, edema, and pain. LLLT is used in different medical settings ranging from dermatology, physiotherapy, and neurology to dentistry. Since the last twenty years, LLLT is becoming a new treatment modality in supportive care for breast cancer. For this review, all existing literature concerning the use of LLLT for breast cancer was used to provide evidence in the following domains: oral mucositis (OM), radiodermatitis (RD), lymphedema, chemotherapy-induced peripheral neuropathy (CIPN), and osteonecrosis of the jaw (ONJ). The findings of this review suggest that LLLT is a promising option for the management of breast cancer treatment-related side effects. However, it still remains important to define appropriate treatment and irradiation parameters for each condition in order to ensure the effectiveness of LLLT.

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Section: Lllt-mechanism Of Action On Cellular and Tissular Levelsupporting

confidence: 64%

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

et al. 2016

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“…LLLT has been shown to be beneficial in facilitating healing of slow or non-healing wounds in laboratory animals [11] and humans [12 -15] . LLLT stimulates cellular physiologic processes [16] .…”

Section: Introductionmentioning

confidence: 99%

Equine wound healing: influence of low level laser therapy on an equine metacarpal wound healing model

Jann

Bartels

Ritchey³

et al. 2012

Photonics &Amp; Lasers in Medicine

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Objective: To evaluate the effects of low level laser therapy (LLLT) on healing of full thickness symmetrical skin wounds in horses. LLLT is a therapeutic modality using the application of light, usually a low power laser or light emitting diode in the power range of 1 mW to 12 W that, in practical terms, promotes tissue regeneration as well as reducing infl ammation and pain. Study design: Experimental study. Animals: Healthy horses (n = 8). Methods: Full thickness, 2.5 cm square skin wounds were created in the mid-metacarpal region on one leg of eight normal horses. LLLT was used on limbs assigned to the experimental group and limbs assigned to the control group were allowed to heal without treatment. LLLT was administered using a line generated optical scanner with a dual diode laser system (model EML; Erchonia Laser Healthcare, McKinney, TX, USA) at a wavelength of 635 nm and an energy output of 17 mW per diode. Wound size was measured for an 80-day period post operatively. Eighty days after surgery incisional biopsies were examined histologically. Results: Wounds treated with LLLT healed faster than the control wounds ( p = 0.01). Wounds treated with LLLT were completely epithelialized at day 80 after surgery. Control wounds were not epithelialized at postoperative day 80. Conclusion: LLLT increased the rate of wound healing. Schl ü sselw ö rter: Wunden; Wundheilung; Mittelfu ß bereich; Low-Level-Laser-Therapie (LLLT); Epithelisierung. Keywords

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“…10 Du ring the last 40 ye ars, its ef fi cacy in wo und re pa ir was in ves ti ga ted and sup por ted with many ani mal [13][14][15][16][17] and hu man stu di es. 20,21 Today, in many co un tri es ex cept Uni ted Sta tes, LLLT is wi dely used for the tre at ment of a va ri ety con diti ons inc lu ding ne u ro lo gic, den tal and der ma to logic di sor ders.…”

Section: Discussionmentioning

confidence: 99%

“…12 Alt ho ugh se ve ral stu di es ha ve in ves ti ga ted its the ra pe u tic bene fit on pres su re ul cers, the cli ni cal use of LLLT for wo und he a ling is still un der in ves ti ga ti on be ca u se many in ves ti ga tors re port conf lic ting fin dings in ani mal and hu man stu di es. [13][14][15][16][17][18][19][20][21] In the pre sent li te ra tu re, the com pa ra ti ve data of both tre at ment mo da li ti es con cer ning wo und he a ling is very li mi ted. 22 Mo re o ver, to the best of our know led ge, the re is no da ta that com pa re the two tre at ment mo da li ti es in ex ci si o nal wo und hea ling in terms of both his to pat ho lo gic and bi oc hemi cal chan ges.…”

mentioning

confidence: 99%

Low-Level Laser Therapy is More Effective Than Pulse Ultrasound Treatment on Wound Healing: Comperative Experimental Study

Tıkız¹,

Angın²,

Demireli³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To investigate and compare the effects of pulse ultrasound (US) and lowlevel laser therapy (LLLT) on wound healing. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Thirty-two rats were included in the study and two full-thickness skin wounds were made on dorsum area of the rats bilaterally, with a 17 mm hole-punch. The animals were divided into two groups. Pulsed US (with a power of 0.1 W/cm 2 , a frequency of 1 MHz, 5 minutes daily) was applied to to the right sided wounds of Group A (n= 16) and Ga-As laser (830 nm wavelength, 0.5 J/ cm 2 dosage of 1 MHz frequency for 1 minute duration) was applied to right sided wounds of Group B (n= 16). Left sided wound were considered as controls and same procedures were applied without any current (sham). Biochemical and histopathological evaluations were performed in each group on 7 th and 15 th days. R Re es su ul lt ts s: : Inflammatory cells tended to decrease in both treatment groups on the 7 th day, however, this finding did not reach a statistical significance (p> 0.05). Fibroblasts and collagen were found to be significantly increased in the laser group when compared to the other group on the 7 th day (p< 0.05). Angiogenesis was found to be significantly increased only in the laser group when compared to the other group on the 15 th day (p< 0.05). There were no significant differences in tissue nitric oxide values between the groups although the values in the laser group tended to be higher on the 15th day (p=0.058) C Co on nc cl lu us si io on n: : In this comparative study, LLLT was found to significantly accelerate mainly proliferative phase while pulse US had no effect on wound healing. Our results support the consideration that LLLT may constitute a beneficial treatment modality for wound healing.K Ke ey y W Wo or rd ds s: : Laser therapy, low-level; ultrasonography; wound healing Ö ÖZ ZE ET T A Am ma aç ç: : Yara iyileşmesinde düşük enerjili lazer tedavisi (DELT) ve kesikli ultrason (US) tedavilerinin etkinliklerini incelemek ve karşılaştırmak. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya 32 rat dahil edildi ve deneklerin dorsal bölgesinde bilateral olarak tüm deri tabakalarını kapsayan 17 mm çapında iki yara oluşturuldu. İki gruba ayrılan deneklerin ilk grubunun (Grup A, n= 16) sağ taraftaki yaralarına kesikli US (1 MHz başlık ile 0.1 W/cm 2 şiddetinde, 5 dakika süreyle) uygulanırken ikinci gruba (Grup B, n= 16) DELT (830 nm dalga boyunda 0.5 j/cm 2 dozunda %50 şiddetinde, 1 dakika süreyle) uygulandı. Sol taraftaki yaralar kontrol olarak alındı ve tedaviler aynı şekillerde ancak ışın verilmeksizin uygulandı (sham). Yedinci ve 15. günlerde sakrifiye edilen deneklerde biyokimyasal ve histopatolojik değerlendirmeler yapıldı. B Bu ul lg gu ul la ar r: : Inflamatuvar hücrelerin yedinci günde her iki tedavi grubunda da azalmış olduğu, ancak istatiksel anlamlılığa ulaşmadığı gözlendi (p> 0.05). Bu dönemde yapılan histolojik incelemelerde fibroblast ve kollajen miktarının lazer g...

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Low‐level light stimulates excisional wound healing in mice

Abstract: Background-Low levels of laser or non-coherent light, termed low-level light therapy (LLLT) have been reported to accelerate some phases of wound healing, but its clinical use remains controversial.

Cited by 152 publications

References 46 publications

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

Equine wound healing: influence of low level laser therapy on an equine metacarpal wound healing model

Low-Level Laser Therapy is More Effective Than Pulse Ultrasound Treatment on Wound Healing: Comperative Experimental Study

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