“…Therefore, if validated for specific settings in Vietnam, algorithmic protocols, such as the HEART Pathway, with adaptations to merge POC decision making, will prove cost-effective for AMI patients and justify countrywide implementation of hs-cTn in clinical laboratories in partnership with POC cTn in emergency rooms in Vietnam. However, a definitive consensus protocol, with consideration of community settings 29 and the potentially adverse impact of low-level cTn cutoffs on resource utilization, 43 needs to be established specifically for Vietnam.…”