Low Mitochondrial DNA Copy Number is Associated With Adverse Clinical Outcomes in Peritoneal Dialysis Patients

Abstract

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Mitochondrial DNA copy number is associated with mortality and infections in a large cohort of patients with chronic kidney disease

“…A more recent study did not find any association with mortality in 120 peritoneal dialysis patients, of whom 24 died. 19 Our study in patients with moderate CKD shows a clear association with a 1.81-fold increased mortality risk in the quartile of patients with the lowest numbers of mtDNA copies. This risk remained significant after extended adjustment for kidney function and CVD risk factors.…”

“…Only 2 studies in peritoneal dialysis patients have been published. Yoon et al 19 found no significant association between mtDNA copy numbers and cardiovascular events for 24 patients with events, out of 120 patients during 3 years of follow-up. The second study indicates that an increased circulating free-mtDNA content (which might be different from cell-derived mtDNA content) correlates with a systemic inflammatory state and is a strong predictor of cardiovascular events.…”

“…15 However, only a few studies have investigated the association between mtDNA copy numbers and clinical outcomes in CKD patients. [16][17][18][19] These studies are characterized by small sample sizes and have led to conflicting results. We therefore explored the association of mtDNA copy numbers with prevalence of cardiovascular disease (CVD), as well as all-cause and cause-specific mortality in 4812 patients of the German Chronic Kidney Disease (GCKD) study, a prospective national CKD cohort study, during a 4-year follow-up.…”

Mitochondrial DNA copy number is associated with all‐cause mortality and cardiovascular events in patients with peripheral arterial disease

“…Patients in the lowest quartile of copy numbers had a 1.81‐fold increased risk for all‐cause mortality after adjusting for kidney function and cardiovascular risk factors . Small studies in patients with end‐stage kidney disease reported conflicting results .…”

“…We recently observed in almost 5000 patients with moderate kidney disease a strong association with all‐cause mortality as well as death due to infections . Other studies in patients with end‐stage kidney disease reported conflicting results . The studies on mtDNA‐CN and cancer are quite heterogeneous depending on cancer type and the source of cells investigated .…”