Low molecular weight chitosan-coated silver nanoparticles are effective for the treatment of MRSA-infected wounds

Peng, Yung-Hsing; Song, Chenlu; Yang, Chuanfeng; Guo, Qige; Yao, Min

doi:10.2147/ijn.s122357

Cited by 69 publications

(32 citation statements)

References 34 publications

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“…Since, the Au NPs spectral peak, of 1.5 mM HAuCl 4 exhibited a gradual increase in the absorption peak with a blue shift of LSPR (λ max =518 nm) and narrow FWHM (110 nm) compared to other HAuCl 4 concentrations of 2.0 and 2.5 mM which were 113 and 115 nm, respectively. Therefore, the LMW Chitosan is more proper efficient rather than HMW and MMW Chitosan as reported before [36][37][38]. Furthermore, this result can be supported by the highest deacetylation degree (DD) value which is approximately more than 75-85% for LMW Chitosan.…”

Section: Uv-visible (Uv-vis) Spectroscopy Analysissupporting

confidence: 71%

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Chitosan Molecular Weight Effects on The Synthesis of Gold Nanoparticles and Catalytic Degradation of Environmental Pollutants

Ibrahim¹

2018

JAP

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Gold nanoparticles (Au NPs) was synthesized with Chitosan different molecular weight (MW) using a microwave as a heating source. Since, Chitosan acts as a reducing and stabilizing agent. The as-synthesized Au NPs were characterized by transmission electron microscopy (TEM) images and selected area electron diffraction patterns (SAED). Furthermore, the Au NPs fabrication was ascertained by UVâ€“Visible spectroscopy (UVâ€“Vis) through the detection of the localized surface plasmon resonance (LSPR) characteristic peak, X-ray powder diffraction (XRD), and energy dispersive X-Ray Spectroscopy (EDS). The formation of the Au NPs was confirmed by the detection of a LSPR peak at 518â€“527 nm in the UVâ€“Vis spectrum. In addition, the XRD studies depicted that the obtained Au NPs were highly crystalline with â€˜face-centeredâ€™ cubic geometry. Moreover, TEM micrographs showed that the most Monodispersed AuNPs was synthesized with low molecular weight (LMW) Chitosan with particle size 4.48Â±0.09 nm. The synthesized Chitosan-Au nanocomposite exhibited an efficient catalytic property in the reduction of two organic environmental pollutants which are, 4-nitrophenol (4-NP) and methyl orange (MO) dye in the presence of sodium borohydride (NaBH4).

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Section: Uv-visible (Uv-vis) Spectroscopy Analysissupporting

confidence: 71%

“…Where, the more free amino groups available for gold ion coordination and reduction, the higher yield of reduction [39]. In addition, in comparison with long-chain HMW Chitosan, the short-chain LMW is better in terms of water solubility and biocompatibility [36].…”

Section: Uv-visible (Uv-vis) Spectroscopy Analysismentioning

confidence: 99%

Chitosan Molecular Weight Effects on The Synthesis of Gold Nanoparticles and Catalytic Degradation of Environmental Pollutants

Ibrahim¹

2018

JAP

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“…Low-molecular weight chitosan-coated Ag NPs have been reported to surpass polyvinylpyrrolidone-coated Ag NPs and Ag NPs without surface stabilizer (uncoated Ag NPs) in efficacy against MRSA with enhanced biocompatibility and reduced body absorption characteristics. 129 Chitosan/TiO 2 / Ag nanocomposites exhibited effective antibacterial activity via ROS generation, lactate dehydrogenase release and inhibited bacterial adhesion. 130 Chitosan/Ag nanocomposites were effective against Salmonella sp., 131 whereas the activity of chitosan-TiO 2 :Cu nanocomposite against E. coli and S. aureus was enhanced in the presence of light.…”

Section: Polymeric Nanocomposites and Nanomaterials Conjugated With Amentioning

confidence: 98%

Nanomaterials for alternative antibacterial therapy

Hemeg

2017

IJN

443

262

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Despite an array of cogent antibiotics, bacterial infections, notably those produced by nosocomial pathogens, still remain a leading factor of morbidity and mortality around the globe. They target the severely ill, hospitalized and immunocompromised patients with incapacitated immune system, who are prone to infections. The choice of antimicrobial therapy is largely empirical and not devoid of toxicity, hypersensitivity, teratogenicity and/or mutagenicity. The emergence of multidrug-resistant bacteria further intensifies the clinical predicament as it directly impacts public health due to diminished potency of current antibiotics. In addition, there is an escalating concern with respect to biofilm-associated infections that are refractory to the presently available antimicrobial armory, leaving almost no therapeutic option. Hence, there is a dire need to develop alternate antibacterial agents. The past decade has witnessed a substantial upsurge in the global use of nanomedicines as innovative tools for combating the high rates of antimicrobial resistance. Antibacterial activity of metal and metal oxide nanoparticles (NPs) has been extensively reported. The microbes are eliminated either by microbicidal effects of the NPs, such as release of free metal ions culminating in cell membrane damage, DNA interactions or free radical generation, or by microbiostatic effects coupled with killing potentiated by the host’s immune system. This review encompasses the magnitude of multidrug resistance in nosocomial infections, bacterial evasion of the host immune system, mechanisms used by bacteria to develop drug resistance and the use of nanomaterials based on metals to overcome these challenges. The diverse annihilative effects of conventional and biogenic metal NPs for antibacterial activity are also discussed. The use of polymer-based nanomaterials and nanocomposites, alone or functionalized with ligands, antibodies or antibiotics, as alternative antimicrobial agents for treating severe bacterial infections is also discussed. Combinatorial therapy with metallic NPs, as adjunct to the existing antibiotics, may aid to restrain the mounting menace of bacterial resistance and nosocomial threat.

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“…Similarly, LMWC-AgNPs exhibited in vivo inhibitory action against MRSA and improved the healing process in relation to untreated mice. Importantly, the adverse effects typically associated with AgNPs on liver function were reduced in mice treated with LMWC-AgNPs [68].…”

Section: Chitosan-based Formulationsmentioning

confidence: 99%

Polysaccharide-Based Formulations for Healing of Skin-Related Wound Infections: Lessons from Animal Models and Clinical Trials

et al. 2019

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Skin injuries constitute a gateway for pathogenic bacteria that can be either part of tissue microbiota or acquired from the environmental. These microorganisms (such as Acinetobacter baumannii, Enterococcus faecalis, Pseudomonas aeruginosa, and Staphylococcus aureus) produce virulence factors that impair tissue integrity and sustain the inflammatory phase leading for establishment of chronic wounds. The high levels of antimicrobial resistance have limited the therapeutic arsenal for combatting skin infections. Thus, the treatment of non-healing chronic wounds is a huge challenge for health services worldwide, imposing great socio-economic damage to the affected individuals. This scenario has encouraged the use of natural polymers, such as polysaccharide, in order to develop new formulations (membranes, nanoparticles, hydrogels, scaffolds) to be applied in the treatment of skin infections. In this non-exhaustive review, we discuss the applications of polysaccharide-based formulations in the healing of infected wounds in animal models and clinical trials. The formulations discussed in this review were prepared using alginate, cellulose, chitosan, and hyaluronic acid. In addition to have healing actions per se, these polysaccharide formulations can act as transdermal drug delivery systems, controlling the release of active ingredients (such as antimicrobial and healing agents). The papers show that these polysaccharides-based formulations are efficient in controlling infection and improve the healing, even in chronic infected wounds. These data should positively impact the design of new dressings to treat skin infections.

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Low molecular weight chitosan-coated silver nanoparticles are effective for the treatment of MRSA-infected wounds

Cited by 69 publications

References 34 publications

Chitosan Molecular Weight Effects on The Synthesis of Gold Nanoparticles and Catalytic Degradation of Environmental Pollutants

Chitosan Molecular Weight Effects on The Synthesis of Gold Nanoparticles and Catalytic Degradation of Environmental Pollutants

Nanomaterials for alternative antibacterial therapy

Polysaccharide-Based Formulations for Healing of Skin-Related Wound Infections: Lessons from Animal Models and Clinical Trials

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