Low molecule weight fucoidan mitigates atherosclerosis in ApoE (-/-) mouse model through activating multiple signal pathway

Xu, Yingjie; Zhu, Wenlong; Wang, Tingting; Jin, Lina; Liu, Tianwei; Li, Xu; Guan, Zijiao; Jiang, Zhifeng; Meng, Xianze; Wang, Jigang; Guo, Yunliang

doi:10.1016/j.carbpol.2018.10.097

Cited by 30 publications

(23 citation statements)

References 45 publications

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“…10,11 The sulfate content of low molecular weight fucoidan (LMWF) (<10 kDa) used in this study is much more than high molecular weight fucoidan, and the biological activity is more efficient. 12 Many studies found that LMWF could promote tumor cell apoptosis by regulating different signaling pathways, thereby further inhibiting the growth and proliferation of cell. 13 It has been confirmed that LMWF inhibited the growth of human cervical cancer cells Hela, 14 human breast cancer cells MCF-7, 15 leukemia cells K562, 16 and lymphoma cells U937, 17 but the role of LMWF in oral cancer has not been studied.…”

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confidence: 99%

Effects of Low Molecular Weight Fucoidan on the Proliferation and Apoptosis of Dysplastic Oral Keratinocyte and Oral Squamous Cell Carcinoma Cells

Wang

et al. 2020

Natural Product Communications

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Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors with high incidence, rapid progress, and high mortality. There are still some defects in the treatments of OSCC, which seriously affect the quality of patients’ life. Therefore, it is urgent to find a safer and more effective treatment for OSCC. Low molecular weight fucoidan (LMWF) has various biological activities, such as antitumor, anti-inflammatory, and antithrombotic, and has no obvious side effects, but the effect of LMWF on OSCC has not been reported. In this study, the effects of LMWF on dysplastic oral keratinocyte (DOK) and OSCC cells SCC-9 and SCC-25 were detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry, TUNEL, colony formation, and wound healing assay, and the expression levels of Notch-1 and Jagged-1 treated with LMWF were detected by RT-qPCR. The results showed that LMWF could inhibit the proliferation and migration of DOK and SCC-9, and promote apoptosis. Low molecular weight fucoidan upregulated the expression of Notch-1 and Jagged-1 in DOK and SCC-9 cells. It indicated that LMWF might promote the apoptosis of DOK and SCC-9 by upregulating the Notch signal pathway, thereby inhibiting cell proliferation and playing an antitumor role. It provided theoretical basis to develop LMWF as a novel therapeutic drug for oral cancer.

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confidence: 99%

Effects of Low Molecular Weight Fucoidan on the Proliferation and Apoptosis of Dysplastic Oral Keratinocyte and Oral Squamous Cell Carcinoma Cells

Wang

et al. 2020

Natural Product Communications

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“…It is worth noting that LMWF is able to stabilize established atherosclerotic lesions because it has great antioxidant activity. LMWF reduces lipid peroxidation and foaming macrophage accumulation, and ameliorates the inflammatory response through down-regulation of IL-6 and up-regulation of IL-10 levels, and by returning p-JNK and cyclin D1 to normal levels [54,55,56]. Other studies reported that LMWF downregulated microparticle release and pro-inflammatory properties of activated human polymorphonuclear neutrophils [57], suppressed the inflammatory response in RAW 264.7 macrophages by inhibiting MAPK and oxidative stress [58], and reduced arthritis through suppressing the Th1 immune response [33].…”

Section: Resultsmentioning

confidence: 99%

Development of Injectable Fucoidan and Biological Macromolecules Hybrid Hydrogels for Intra-Articular Delivery of Platelet-Rich Plasma

Chang

Tsai

et al. 2019

Marine Drugs

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Platelet-rich plasma (PRP) is rich in growth factors and has commonly been utilized in the repair and regeneration of damaged articular cartilage. However, the major drawbacks of direct PRP injection are unstable biological fixation and fast or burst release of growth factors. Fucoidan is a heparinoid compound that can bind growth factors to control their release rate. Furthermore, fucoidan can reduce arthritis through suppressing inflammatory responses and thus it has been reported to prevent the progression of osteoarthritis, promote bone regeneration and accelerate healing of cartilage injury. Injectable hydrogels can be used to deliver cells and growth factors for an alternative, less invasive treatment of cartilage defects. In this study, hyaluronic acid (HA) and fucoidan (FD) was blended with gelatin (GLT) and the GLT/HA/FD hybrid was further cross-linked with genipin (GP) to prepare injectable GP-GLT/HA/FD hydrogels. The gelation rate was affected by the GP, GLT, HA and FD concentrations, as well as the pH values. The addition of HA and FD to GLT networks improved the mechanical strength of the hydrogels and facilitated the sustained release of PRP growth factors. The GP-GLT/HA/FD hydrogel showed adequate injectability, shape-persistent property and strong adhesive ability, and was more resistant to enzymatic degradation. The PRP-loaded GP-GLT/HA/FD hydrogel promoted cartilage regeneration in rabbits, which may lead to an advanced PRP therapy for enhancing cartilage repair.

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“…Fucoidan decreases the area of atherosclerotic plaques. It has been reported that apolipoprotein E-deficient (ApoE-/-) mice receiving an atherogenic diet with fucoidan show ameliorated atherosclerotic lesions in the aortas in a dose-dependent manner [13,14]. Additionally, spontaneously hyperlipidemia mice received high-fat diet supplemented with fucoidan exhibited inhibition in the development of AS [15].…”

Section: Fucoidanmentioning

confidence: 99%

Current Research Landscape of Marine-Derived Anti-Atherosclerotic Substances

et al. 2020

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Atherosclerosis is a chronic disease characterized by lipid accumulation and chronic inflammation of the arterial wall, which is the pathological basis for coronary heart disease, cerebrovascular disease and thromboembolic disease. Currently, there is a lack of low-cost therapeutic agents that effectively slow the progression of atherosclerosis. Therefore, the development of new drugs is urgently needed. The research and development of marine-derived drugs have gained increasing interest from researchers across the world. Many marine organisms provide a rich material basis for the development of atherosclerotic drugs. This review focuses on the latest technological advances in the structures and mechanisms of action of marine-derived anti-atherosclerotic substances and the challenges of the application of these substances including marine polysaccharides, proteins and peptides, polyunsaturated fatty acids and small molecule compounds. Here, we describe the theoretical basis of marine biological resources in the treatment of atherosclerosis.

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Low molecule weight fucoidan mitigates atherosclerosis in ApoE (-/-) mouse model through activating multiple signal pathway

Cited by 30 publications

References 45 publications

Effects of Low Molecular Weight Fucoidan on the Proliferation and Apoptosis of Dysplastic Oral Keratinocyte and Oral Squamous Cell Carcinoma Cells

Effects of Low Molecular Weight Fucoidan on the Proliferation and Apoptosis of Dysplastic Oral Keratinocyte and Oral Squamous Cell Carcinoma Cells

Development of Injectable Fucoidan and Biological Macromolecules Hybrid Hydrogels for Intra-Articular Delivery of Platelet-Rich Plasma

Current Research Landscape of Marine-Derived Anti-Atherosclerotic Substances

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