2014
DOI: 10.1152/ajpregu.00206.2014
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Low O2-induced ATP release from erythrocytes of humans with type 2 diabetes is restored by physiological ratios of C-peptide and insulin

Abstract: Richards JP, Yosten GL, Kolar GR, Jones CW, Stephenson AH, Ellsworth ML, Sprague RS. Low O2-induced ATP release from erythrocytes of humans with type 2 diabetes is restored by physiological ratios of C-peptide and insulin.

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Cited by 26 publications
(49 citation statements)
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“…To examine the effect of US cavitation on ischemic limb perfusion, a murine model of chronic PAD was produced by ligation of several major limb inflow vessels to produce moderate ischemia. 38 Because hypoxia is a recognized stimulus for ATP release from RBCs, 39,40 we first performed in vivo optical imaging to examine whether US cavitation stimulates ATP release in the setting of chronic ischemia. Focal ATP release was seen at the site of US exposure (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…To examine the effect of US cavitation on ischemic limb perfusion, a murine model of chronic PAD was produced by ligation of several major limb inflow vessels to produce moderate ischemia. 38 Because hypoxia is a recognized stimulus for ATP release from RBCs, 39,40 we first performed in vivo optical imaging to examine whether US cavitation stimulates ATP release in the setting of chronic ischemia. Focal ATP release was seen at the site of US exposure (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Knockdown of GPR146 completely inhibited C-peptide-induced cFos mRNA expression in a human gastric cell line (KATOIII), and C-peptide exhibited significant co-localization with GPR146 on KATOIII cell membranes (51). Furthermore, incubation with an antibody directed against the second extracellular domain of GPR146 completely blocked the effect of C-peptide, but not insulin, on ATP release from human erythrocytes (41). These data suggest that the actions of C-peptide indeed are receptor mediated and that GPR146 is part of the C-peptide signaling complex, if not the endogenous receptor of this peptide hormone.…”
Section: Are the Effects Of C-peptide Receptor Mediated?mentioning
confidence: 93%
“…C-peptide exhibits a bell-shaped dose-response curve in most cell systems, and it has been hypothesized that C-peptide function is dependent on the molar ratio of C-peptide to insulin (14), as has been observed in human erythrocytes (40,41).…”
Section: What Is the Relationship Between C-peptide And Insulin?mentioning
confidence: 95%
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