Low PAI‐1 activity in relation to inflammatory parameters, insulin profile and body mass index

Abstract

Abstract. Å gren A, Wiman B, Schulman S (Karolinska Institute and Coagulation Unit and Karolinska University Hospital; Karolinska University Hospital, Stockholm, Sweden; and McMaster University, Hamilton, ON, Canada). Low PAI-1 activity in relation to inflammatory parameters, insulin profile and body mass index. J Intern Med 2008; 264: 586-592.Background and objective. High plasminogen activator inhibitor type 1 (PAI-1) activity is associated with inflammatory reactions and insulin resistance, but it is unclear what regulates PAI-1 activity at the low end. The purpose of this study was to investigate if patients with low PAI-1 activity have a lack of inflammatory response or a low insulin level.