Low Plasma Apelin Levels in Newly Diagnosed Type 2 Diabetes Mellitus

Erdem, Gökhan; Doğru, Teoman; Taşçı, İlker; Sönmez, Alper; Tapan, Serkan

doi:10.1055/s-2007-1004564

Cited by 118 publications

(91 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Apelin is linked to the pathogenesis of T2D -plasma apelin concentrations are increased in insulin-resistant patients (Li et al 2006), in type T2D patients (Cavallo et al 2012) and in morbidly obese T2D individuals (Soriguer et al 2009), perhaps indicating a compensatory role of apelin in the reduction of insulin resistance. However, conversely, plasma apelin levels are reduced in newly diagnosed T2D patients (Erdem et al 2008) and increased in T2D patients and obese non-diabetic individuals (Boucher et al 2005, Dray et al 2010. The increased expression of apelin in plasma and adipose tissue of obese individuals can, however, be reversed by a hypocaloric diet .…”

Section: Metabolic Actions Of Apelin/apjmentioning

confidence: 96%

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

O’Carroll

Lolait

Harris

et al. 2013

Journal of Endocrinology

292

216

View full text Add to dashboard Cite

The apelin receptor (APJ; gene symbol APLNR) is a member of the G protein-coupled receptor gene family. Neural gene expression patterns of APJ, and its cognate ligand apelin, in the brain implicate the apelinergic system in the regulation of a number of physiological processes. APJ and apelin are highly expressed in the hypothalamo-neurohypophysial system, which regulates fluid homeostasis, in the hypothalamic-pituitary-adrenal axis, which controls the neuroendocrine response to stress, and in the forebrain and lower brainstem regions, which are involved in cardiovascular function. Recently, apelin, synthesised and secreted by adipocytes, has been described as a beneficial adipokine related to obesity, and there is growing awareness of a potential role for apelin and APJ in glucose and energy metabolism. In this review we provide a comprehensive overview of the structure, expression pattern and regulation of apelin and its receptor, as well as the main second messengers and signalling proteins activated by apelin. We also highlight the physiological and pathological roles that support this system as a novel therapeutic target for pharmacological intervention in treating conditions related to altered water balance, stress-induced disorders such as anxiety and depression, and cardiovascular and metabolic disorders.

show abstract

Section: Metabolic Actions Of Apelin/apjmentioning

confidence: 96%

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

O’Carroll

Lolait

Harris

et al. 2013

Journal of Endocrinology

292

216

View full text Add to dashboard Cite

show abstract

“…reported that serum apelin levels in newly diagnosed diabetes patients decreased. 15,27 Similarly, there was a decrease in serum apelin levels in Type 2 diabetes in Chinese population. 28 On the other hand, children with Type 1 diabetes had high serum apelin levels.…”

Section: Discussionmentioning

confidence: 88%

“…Increased apelin with hyperinsulinemia was observed in obese subjects. [14][15][16] There are studies reporting that the antioxidant capacity is impaired in obesity. 17,18 Sudden or excessive oxygen entrance into the organism due to various metabolic reasons, antioxidant defense system insufficiency or oxidant-antioxidant balance to gravitate towards the oxidant side, which then leads to occurrence of oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

On the relationship between serum apelin levels and some parameters related to oxidative stress and energy metabolism in obese and non-obese

Fakıoğlu¹,

Yiğitbaşı²,

Emekli³

2017

actapharm

View full text Add to dashboard Cite

“…Other adipose tissue-derived peptides such as leptin (6), apelin (7) and visfatin (8) were also reported to have some effects on the atheroclerotic diseases. Among these, synthesis and/or secretion of apelin is dysregulated in a number of conditions leading to atherosclerosis including hypertension (9), diabetes (3,10), and hypercholesterolemia (2,4). Since apelin receptor is expressed by a variety of cells that are involved in atherosclerotic processes, this novel peptide need to be searched thoroughly for its roles in the mechanism of cardiovascular diseases.…”

Section: Atherosclerosis and Adipose Tissue-derived Peptidesmentioning

confidence: 99%

Brain derived neurotrophic factor (BDNF) in cardiometabolic physiology and diseases

Taşçı¹,

Kabul²,

Aydoğdu³

2012

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

Important advances in our understanding of the relationships between adipose tissue derived peptides, namely adipokines, and their effects on cardiovascular functions have been achieved in recent years. Growing knowledge of adipokine biology is revealing the complexity of these proteins. Adipose tissue releases some other proteins called neurotrophins that are mainly active in central and peripheral nervous system. However, secretion and activity of these hormones are not only limited to neuronal cells and tissues, but they also take part in adipose tissue development, energy metabolism, glucose utilization, insulin sensitivity, inflammation, lipoprotein synthesis, and atherosclerosis. In this review, we describe the most recent advances in the functions of brain derived nerve growth factor (BDNF), a major type of neurotrophins, focusing primarily on cardiovascular and metabolic diseases. (Anadolu Kardiyol Derg 2012; 12: 684-8) Key words: Brain derived nerve growth factor, cardiovascular disease, atherosclerosis, dyslipidemia, diabetes mellitus Review Derleme 684ÖZET Son yıllarda, adipokinler olarak bilinen adipoz doku kaynaklı peptidler ve bunların kardiyovasküler fonksiyonlar üzerine etkileri üzerine önemli ilerlemeler sağlanmıştır. Adipokin biyolojisi hakkında bilgiler çoğaldıkça bu proteinlerin karmaşık görünümü aydınlatılmaktadır. Adipoz doku nörotrofin-ler olarak bilinen ve temel olarak santral ve periferal sinir sisteminde görev yapan diğer bazı proteinleri de salgılar. Bununla beraber, bu hormonların sekresyon ve aktivitesi sadece nöronal hücreler ve dokularla sınırlı olmayıp yağ dokusu gelişimi, enerji metabolizması, glikoz kullanımı, insülin duyarlılığı, enflamasyon, lipoprotein sentezi ve aterosklerozda da rol oynarlar. Bu derlemede majör bir nörotrofin olan beyinden türemiş nörotrofik faktör (BDNF) ile ilgili en son veriler, özellikle kardiyovasküler ve metabolik hastalıklar üzerinden irdelenmiştir.

show abstract

Low Plasma Apelin Levels in Newly Diagnosed Type 2 Diabetes Mellitus

Cited by 118 publications

References 28 publications

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

On the relationship between serum apelin levels and some parameters related to oxidative stress and energy metabolism in obese and non-obese

Brain derived neurotrophic factor (BDNF) in cardiometabolic physiology and diseases

Contact Info

Product

Resources

About