Low preoperative skeletal muscle density is predictive for negative postoperative outcomes in older women with ovarian cancer

Zanden, Vera van der; Soolingen, Neeltje J. van; Viddeleer, Alain R.; Trum, J. W.; Amant, Frédéric; Mourits, Marian J.E.; Portielje, Johanneke E.A.; Bos, Frederiek van den; Kroon, Cornelis D. de; Kagie, Marjolein J.; Oei, Stanley; Baalbergen, Astrid; Jong, Anne-Marie L.D. van Haaften-de; Houtsma, Danny; Munster, Barbara C. Van; Souwer, Esteban T.D.

doi:10.1016/j.ygyno.2021.05.039

Cited by 14 publications

(7 citation statements)

References 34 publications

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“…This result is interesting because SMD represents the fatty infiltration of muscle (with higher values corresponding to lower fat infiltration of the muscle fibers), which is considered an indirect estimate of muscle quality. Furthermore, other studies have also demonstrated that SMD is associated with prognosis [51][52][53][54].…”

Section: Discussionmentioning

confidence: 92%

Is Computed-Tomography-Based Body Composition a Reliable Predictor of Chemotherapy-Related Toxicity in Pancreatic Cancer Patients?

Cefalì,

Scala,

Pavone

et al. 2023

Cancers

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Background: Malnutrition, loss of weight and of skeletal muscle mass are frequent in pancreatic cancer patients, a majority of which will undergo chemotherapy over the course of their disease. Available data suggest a negative prognostic role of these changes in body composition on disease outcomes; however, it is unclear whether tolerance to chemotherapeutic treatment is similarly and/or negatively affected. We aimed to explore this association by retrospectively assessing changes in body composition and chemotherapy-related toxicity in a cohort of advanced pancreatic cancer patients. Methods: Body composition was evaluated through clinical parameters and through radiological assessment of muscle mass, skeletal muscle area, skeletal muscle index and skeletal muscle density; and an assessment of fat distribution by subcutaneous adipose tissue and visceral adipose tissue. We performed descriptive statistics, pre/post chemotherapy comparisons and uni- and multivariate analyses to assess the relation between changes in body composition and toxicity. Results: Toxicity risk increased with an increase of skeletal muscle index (OR: 1.03) and body mass index (OR: 1.07), whereas it decreased with an increase in skeletal muscle density (OR: 0.96). Multivariate analyses confirmed a reduction in the risk of toxicity only with an increase in skeletal muscle density (OR: 0.96). Conclusions: This study suggests that the retrospective analysis of changes in body composition is unlikely to be useful to predict toxicity to gemcitabine—nab-paclitaxel.

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Section: Discussionmentioning

confidence: 92%

Is Computed-Tomography-Based Body Composition a Reliable Predictor of Chemotherapy-Related Toxicity in Pancreatic Cancer Patients?

Cefalì,

Scala,

Pavone

et al. 2023

Cancers

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“…From the three electronic databases and references of related studies, we identifed 1,979 studies. After reviewing the title, abstract, and full text, nine studies [13][14][15][16][24][25][26][27][28] were fnally included in this systematic review and meta-analysis (Figure 1). Te median NOS quality score was 8 (range from 6 to 8) (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Low Skeletal Muscle Mass and the Incidence of Delirium in Hospitalized Older Patients: A Systematic Review and Meta-Analysis of Observational Studies

Shen,

Wan,

Zhao

et al. 2023

International Journal of Clinical Practice

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Background. Both low skeletal muscle mass and delirium are prevalent in older hospitalized patients, while their associations are unclear. This systematic review and meta-analysis aim to investigate the associations between low skeletal muscle mass and the incidence of delirium in hospitalized patients. Methods. The PubMed, Web of Science, and Embase were searched for relevant studies published before May 2022, and we conducted this systematic review and meta-analysis according to the PRISMA and MOOSE guidelines. The summary odds ratios (OR) and 95% confidence intervals (CI) were estimated, and subgroup analyses were also conducted according to the age and major surgeries. Results. Finally, nine studies with 3 828 patients were included. The pooled result showed no significant association between low skeletal muscle mass and the incidence of delirium (OR 1.69, 95% CI 0.85 to 2.52). However, sensitivity analysis suggested that one study caused a significant alteration of the summary result, and the meta-analysis of the remaining 8 studies showed that low skeletal muscle mass was significantly associated with an 88% increased incidence of delirium (OR 1.88, 95% CI 1.43 to 2.33). Furthermore, subgroup analyses indicated that low skeletal muscle mass was associated with a higher incidence of delirium in patients ≥75 years old or undergoing major surgeries instead of those <75 years old or without surgeries, respectively. Conclusions. Hospitalized patients with low skeletal muscle mass might have higher incidence of delirium, particularly in those of older age and undergoing major surgeries. Therefore, great attention should be paid to these patients.

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“…In recent years, there have been reports not only on the volume and the area of skeletal muscle but also on the skeletal muscle density, with individuals having low skeletal muscle density often referred to as having myosteatosis [36][37][38][39][40]. Moreover, muscle density can also be measured using CT, similar to PA and PV.…”

Section: Discussionmentioning

confidence: 99%

Use of 3D-CT-derived psoas major muscle volume in defining sarcopenia in colorectal cancer

Takahashi,

Sakamoto,

Kogure

et al. 2024

BMC Cancer

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Background Sarcopenia is characterized by reduced skeletal muscle volume and is a condition that is prevalent among elderly patients and associated with poor prognosis as a comorbidity in malignancies. Given the aging population over 80 years old in Japan, an understanding of malignancies, including colorectal cancer (CRC), complicated by sarcopenia is increasingly important. Therefore, the focus of this study is on a novel and practical diagnostic approach of assessment of psoas major muscle volume (PV) using 3-dimensional computed tomography (3D-CT) in diagnosis of sarcopenia in patients with CRC. Methods The subjects were 150 patients aged ≥ 80 years with CRC who underwent primary tumor resection at Juntendo University Hospital between 2004 and 2017. 3D-CT measurement of PV and conventional CT measurement of the psoas major muscle cross-sectional area (PA) were used to identify sarcopenia (group S) and non-sarcopenia (group nS) cases. Clinicopathological characteristics, operative results, postoperative complications, and prognosis were compared between these groups. Results The S:nS ratios were 15:135 for the PV method and 52:98 for the PA method. There was a strong positive correlation (r = 0.66, p < 0.01) between PVI (psoas major muscle volume index) and PAI (psoas major muscle cross-sectional area index), which were calculated by dividing PV or PA by the square of height. Surgical results and postoperative complications did not differ significantly in the S and nS groups defined using each method. Overall survival was worse in group S compared to group nS identified by PV (p < 0.01), but not significantly different in groups S and nS identified by PA (p = 0.77). A Cox proportional hazards model for OS identified group S by PV as an independent predictor of a poor prognosis (p < 0.05), whereas group S by PA was not a predictor of prognosis (p = 0.60). Conclusions The PV method for identifying sarcopenia in elderly patients with CRC is more practical and sensitive for prediction of a poor prognosis compared to the conventional method.

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Low preoperative skeletal muscle density is predictive for negative postoperative outcomes in older women with ovarian cancer

Cited by 14 publications

References 34 publications

Is Computed-Tomography-Based Body Composition a Reliable Predictor of Chemotherapy-Related Toxicity in Pancreatic Cancer Patients?

Is Computed-Tomography-Based Body Composition a Reliable Predictor of Chemotherapy-Related Toxicity in Pancreatic Cancer Patients?

Low Skeletal Muscle Mass and the Incidence of Delirium in Hospitalized Older Patients: A Systematic Review and Meta-Analysis of Observational Studies

Use of 3D-CT-derived psoas major muscle volume in defining sarcopenia in colorectal cancer

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