Low‐resolution colonic manometry leads to a gross misinterpretation of the frequency and polarity of propagating sequences: Initial results from fiber‐optic high‐resolution manometry studies

Dinning, P. G.; Wiklendt, L.; Gibbins, I.; Patton, V.; Bampton, P.; Lubowski, D. Z.; Cook, I. J.; Arkwright, J. W.

doi:10.1111/nmo.12170

Cited by 94 publications

(120 citation statements)

References 32 publications

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“…Overall, these studies have demonstrated that the colonic response to a meal (i.e. the number of retrograde propagating sequences and the number of high-amplitude propagating sequences) is reduced in adults with functional constipation as compared to healthy subjects (Dinning et al, 2013). In adults with functional diarrhea, the number of high and low amplitude anterograde propagating sequences was increased, while simultaneous and retrograde activity was less frequent (Herbst et al, 1997).…”

Section: Invasive Methodologiesmentioning

confidence: 86%

“…As reported by Dinning and colleagues, the study of colonic motility was performed with catheters applying different recording systems (water-perfused or solid state) but generally allowing to measure the pressure created by colonic contractions on a limited number of pressure sensors (from 4 to 16) spaced 7-12 cm one from each other (conventional or low-resolution manometry) (Dinning et al, 2013). Manometric recordings of the relatively inaccessible human colon are complicated by a number of technical difficulties that typically necessitate partial or total removal of colonic contents in order to position a recording catheter.…”

Section: Invasive Methodologiesmentioning

confidence: 99%

“…Recently, the introduction of the high-resolution manometry (HRM) has revealed new aspects of the colonic motility in healthy volunteers (Dinning et al, 2013). Two types of catheters have been applied: a fiber-optic catheter with up to 90 recording sensors spaced 1 cm from each other (Dinning et al, 2013) and a solid state catheter with up to 40 pressure sensors spaced 1-2.5 cm from each other (Chen et al, 2014;Corsetti et al, 2016).…”

Section: Invasive Methodologiesmentioning

confidence: 99%

“…Two types of catheters have been applied: a fiber-optic catheter with up to 90 recording sensors spaced 1 cm from each other (Dinning et al, 2013) and a solid state catheter with up to 40 pressure sensors spaced 1-2.5 cm from each other (Chen et al, 2014;Corsetti et al, 2016). In a study with a fiber-optic catheter, the majority of activity in the postprandial period were retrograde propagating sequences, mainly occurring in the sigmoid region (Dinning et al, 2013). The relevance of simultaneous pressurization sequences, previously observed in conventional manometry studies, was confirmed in several studies using a HRM solid state catheter (Chen et al, 2014;Corsetti et al, 2016).…”

Section: Invasive Methodologiesmentioning

confidence: 99%

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Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

Hens

Corsetti

Spiller

et al. 2017

International Journal of Pharmaceutics

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(2017) Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities. International Journal of Pharmaceutics, 519 (1-2). pp. 79-97. ISSN 1873-3476Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/39960/1/FinalVersion-Revised-FOR_EPRINTS_1_YEAR_EMBARGO_ELSEVIER.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the Creative Commons Attribution Non-commercial No Derivatives licence and may be reused according to the conditions of the licence. For more details see: http://creativecommons.org/licenses/by-nc-nd/2.5/ A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. After oral intake, a drug formulation is challenged by several gastrointestinal (GI) barriers. Complex variables such as pH, GI secretions and GI transit/motility along the GI tract can affect drug release and absorption in a positive or negative way depending on the physicochemical properties of the drug compound (e.g. pH/pKa interplay for ionizable drugs) and/or the formulation characteristics (e.g. pHsensitive coating). In addition, inter-subject variability in characteristics of the GI environment may cause variable drug absorption and systemic drug availability (Riethorst et al., 2015). Determining the median and range for specific GI variables, and understanding how they influence oral drug behavior along the GI tract, will be helpful in the field of drug development. 2The present review provides an overview of different methodologies that can be applied to study physiological variables of the human GI tract and their impact on oral drug absorption in healthy and patient populations. The methodologies have been subdivided into two groups: (i) noninvasive and (ii) invasive methodologies. Although some of the methodologies are more historical than operational, they have been of paramount importance for innovations in drug and formulation development; in addition, they have created the basis for several novel methodologies, leading to an in-depth comprehension of different GI variables: gastric emptying (magnetic resonance imaging (MRI), scintigraphy, acetaminophen absorption technique, ultrasonography, breath test, intraluminal sampling and telemetry), motility (MRI, small intestinal/colonic manometry and telemetry), GI volume changes (MRI and ultrasonography), temperature (telemetry) and GI pH (intraluminal sampling and telemetry). Noninvasive methodologiesa. Scintigraphy Disturbances in the normal movement of food along the GI tract can be associated with abdominal pain, early satiety and nausea. Measurement of GI transit, es...

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Section: Invasive Methodologiesmentioning

confidence: 86%

Section: Invasive Methodologiesmentioning

confidence: 99%

Section: Invasive Methodologiesmentioning

confidence: 99%

Section: Invasive Methodologiesmentioning

confidence: 99%

See 2 more Smart Citations

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

Hens

Corsetti

Spiller

et al. 2017

International Journal of Pharmaceutics

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“…Analysis of the fiberoptic data was performed using software (that we called "PlotHRM") developed by one of the authors (L. Wiklendt). PlotHRM was written in Matlab (MathWorks, Natick, MA) and Java (Sun Microsystems, Santa Clara, CA) (11,19).…”

Section: Recording Methodsmentioning

confidence: 99%

Neurally mediated propagating discrete clustered contractions superimposed on myogenic ripples in ex vivo segments of human ileum

Kuizenga

Sia

Dodds

et al. 2015

American Journal of Physiology-Gastrointestinal and Liver Physi

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Kuizenga MH, Sia TC, Dodds KN, Wiklendt L, Arkwright JW, Thomas A, Brookes SJ, Spencer NJ, Wattchow DA, Dinning PG, Costa M. Neurally mediated propagating discrete clustered contractions superimposed on myogenic ripples in ex vivo segments of human ileum. Am J Physiol Gastrointest Liver Physiol 308: G1-G11, 2015. First published November 13, 2014; doi:10.1152/ajpgi.00230.2014.-Narrow muscle strips have been extensively used to study intestinal contractility. Larger specimens from laboratory animals have provided detailed understanding of mechanisms that underlie patterned intestinal motility. Despite progress in animal tissue, investigations of motor patterns in large, intact specimens of human gut ex vivo have been sparse. In this study, we tested whether neurally dependent motor patterns could be detected in isolated specimens of intact human ileum. Specimens (n ϭ 14; 7-30 cm long) of terminal ileum were obtained with prior informed consent from patients undergoing colonic surgery for removal of carcinomas. Preparations were set up in an organ bath with an array of force transducers, a fiberoptic manometry catheter, and a video camera. Spontaneous and distension-evoked motor activity was recorded, and the effects of lidocaine, which inhibits neural activity, were studied. Myogenic contractions (ripples) occurred in all preparations (6.17 Ϯ 0.36/min). They were of low amplitude and formed complex patterns by colliding and propagating in both directions along the specimen at anterograde velocities of 4.1 Ϯ 0.3 mm/s and retrogradely at 4.9 Ϯ 0.6 mm/s. In five specimens, larger amplitude clusters of contractions were seen (discrete clustered contractions), which propagated aborally at 1.05 Ϯ 0.13 mm/s and orally at 1.07 Ϯ 0.09 mm/s. These consisted of two to eight phasic contractions that aligned with ripples. These motor patterns were abolished by addition of lidocaine (0.3 mM). The ripples continued unchanged in the presence of this neural blocking agent. These results demonstrate that both myogenic and neurogenic motor patterns can be studied in isolated specimens of human small intestine. small intestine; motor patterns; enteric nervous system; myogenic; neurogenic PROPULSION AND MIXING OF INTESTINAL CONTENTS along the digestive tract are essential for normal digestion. The motor patterns underlying these functions are due to the coordinated contractions and relaxations of the smooth muscle layers of the intestine. The internal circular smooth muscle layer and the external longitudinal smooth muscle layer are controlled by two main mechanisms. Myogenic activity is driven by the nonneural pacemaker cells, the interstitial cells of Cajal. Neurogenic control is mediated by circuits in the enteric nervous system. These two types of activity combine to generate the motor patterns that mix and propel luminal content (14,29). Most of our understanding of these mechanisms has been derived from animal studies. Although the basic functions of the gastrointestinal tract are similar between human and animals, there are si...

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Approach to the Patient with Constipation

Rao¹,

Camilleri²

2015

Yamada' S Textbook of Gastroenterology

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Low‐resolution colonic manometry leads to a gross misinterpretation of the frequency and polarity of propagating sequences: Initial results from fiber‐optic high‐resolution manometry studies

Cited by 94 publications

References 32 publications

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

Neurally mediated propagating discrete clustered contractions superimposed on myogenic ripples in ex vivo segments of human ileum

Approach to the Patient with Constipation

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