Low risk stage I endometrial carcinoma: Prognostic factors and outcomes

Yöney, Adnan; Yildirim, Cenk; Bati, Y; Ünsal, Mehmet

doi:10.4103/0019-509x.82895

Cited by 11 publications

(7 citation statements)

References 18 publications

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“…15,16 Complete surgical staging, which includes lymph node dissection, not only is thought to be therapeutic but also assists in tailoring adjuvant therapy accordingly. Low-risk patients (grade 1, 2 and G50% myometrial involvement) have less than 5% risk of pelvic lymph node metastasis, which increases to 15% for grade 1, 2 with greater than 50% myometrial involvement, and up to 40% for grade 3 with less than 50% myometrial involvement.…”

Section: Discussionmentioning

confidence: 99%

Clinical Outcome of Early-Stage Endometroid Adenocarcinoma

Mahantshetty¹,

Aggarwal

D³

et al. 2013

International Journal of Gynecological Cancer

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Section: Discussionmentioning

confidence: 99%

Clinical Outcome of Early-Stage Endometroid Adenocarcinoma

Mahantshetty¹,

Aggarwal

D³

et al. 2013

International Journal of Gynecological Cancer

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“…The recurrence rates in patients with low-risk (stage I and grade 1 or 2 and endometrioid histology) EC after hysterectomy and bilateral salpingo-oophorectomy have been reported as 3.2% and 3.6%, for observation and adjuvant radiotherapy groups, respectively [21]. Patients receiving adjuvant radiotherapy have been reported to be less likely to have a recurrence [20].…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Recurrence in Low-Risk Endometrial Cancer: A Case-Control Study

et al. 2018

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Aim: The aim of this study was to investigate the risk factors for recurrence in patients with low-risk endometrial cancer (EC). Patients and Methods: This retrospective study was performed using 10 gynecological oncology department databases. Patients who met the following criteria were included in the study: (a) endometrioid-type histology, (b) histological grade 1 or 2, (c) no or < 50% myometrial invasion, (d) no intraoperative evidence of extrauterine spread, and (e) the patient underwent at least a pelvic lymphadenectomy. Recurrence was detected in 56 patients who were histologically diagnosed with low-risk EC, and these patients made up the case group. A total of 224 patients with low-risk EC without recurrence were selected (control group) using a dependent random sampling method. The case and control groups were match-paired in terms of grade, stage, and operative technique. Results: Lymphovascular space invasion (LVSI) (odds ratio (OR) 5.8, 95% confidence interval (CI) 2.0-16.9; p = 0.001) and primary tumor diameter (PTD) ≥ 20 mm (OR 6.6, 95% CI 2.7-15.8; p < 0.001) were found to be independent risk factors for recurrence in women with low-risk EC. Conclusion: The presence of LVSI and PTD ≥ 20 mm seem to be significant risk factors for recurrence in women with low-risk EC.

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“…Some mathematical models with clinical indicators and ultrasonographic parameters were proposed in the literature. It was evident that the EC of older menopause patients had the higher risks of the malignant degree [9][10][11][12]. By multi-variable analysis, the clinical indicator of PA was thought as an independent prognosticator and with a cut-off threshold of 80 years [13].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of menopausal endometrial lesions via mathematical modeling clinical indicators and ultrasonographic parameters

Zhu¹,

Tang²,

Qiao³

et al. 2022

THC

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BACKGROUND: The diagnosis of benign and malignant menopausal endometrial lesions (MEL) is often misled by complicated clinical indicators and ultrasonographic parameters in actual clinical applications. OBJECTIVE: To investigate the performance of clinical indicators and ultrasonographic parameters in the diagnosis of MEL. METHODS: A cohort of 156 enrolled menopausal patients with MEL was divided into benign group (128 cases) and malignant group (28 cases). Two clinical indicators of patient age (PA), abnormal vaginal bleeding (AVB) and three transvaginal ultrasonography (TVS) parameters of endometrial thickness (ET), endometrial uneven echo (EUE) and endometrial blood flow signal (EBFS) were measured for the mathematical modelling. The performance of combined indicators and individual indicators were firstly compared, and then the optimized combined indicators was compared with corresponding individual indicators, respectively. RESULTS: Our experiments verified that the mathematical modelling presented robust capabilities in the diagnosis of MEL with the sensitivity, specificity and AUC of 78.6%, 75.8% and 0.83 for combined indicators, and 75.0%, 81.3% and 0.85 for optimized combined indicators, respectively. The cut off thresholds of PA was 57.5 years, ET was 11.5 mm. Furthermore, the AVB presented the most important risk factor among the optimized indicators of PA, ET and AVB (P< 0.05). CONCLUSIONS: The combined indicators presented better performance in differentiating benign and malignant MEL and the AVB demonstrated the most capability for clinical applications.

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Low risk stage I endometrial carcinoma: Prognostic factors and outcomes

Abstract: LC and OS rates are high in the low-risk group of patients; however, current adjuvant therapies did not improve the outcomes. Age over 60 years and the presence of LVI have negative effects on outcomes in this group of patients.

Cited by 11 publications

References 18 publications

Clinical Outcome of Early-Stage Endometroid Adenocarcinoma

Clinical Outcome of Early-Stage Endometroid Adenocarcinoma

Risk Factors for Recurrence in Low-Risk Endometrial Cancer: A Case-Control Study

Evaluation of menopausal endometrial lesions via mathematical modeling clinical indicators and ultrasonographic parameters

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