Low serum C4 concentrations in type-1 diabetes mellitus

Chiarelli, Francesco; Verrotti, A.; Penna, G. La; Morgese, G

doi:10.1007/bf00442223

Cited by 22 publications

(4 citation statements)

References 10 publications

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“…The albumin excretion rate was measured in at least five overnight urine collections, as described previously (10). Persistent microalbuminuria, a marker of incipient diabetic nephropathy (11), was defined as an albumin excretion rate of more than 20 fjig/ minute but below 200 (xg/minute in at least three urine collections.…”

Section: Methodsmentioning

confidence: 99%

Necrobiosis Lipoidica Diabeticorum in Children and Adolescents: A Clue for Underlying Renal and Retinal Disease

Verrotti

Chiarelli

Amerio

et al. 1995

Pediatric Dermatology

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The prevalence of persistent microalbuminuria, retinopathy, and peripheral and autonomic neuropathy was assessed in 18 children and adolescents with type 1 (insulin-dependent) diabetes mellitus (IDDM) who suffered from necrobiosis lipoidica diabeticorum (NLD) and in 40 diabetics without NLD, matched for sex, age, duration of disease, and metabolic control. The mean +/- SD age of the patients was 15.1 +/- 8.6 years (range 7.9-23.9 yrs) and their duration of IDDM was 10.9 +/- 8.1 years (range 7.1-21.0 yrs). Their mean glycosylated hemoglobin level was 9.9 +/- 5.0% (7.3-16.6%) and their fructosamine level was 274 +/- 180 mumol/L (199-466 mumol/L). Patients with NLD had a higher frequency of persistent microalbuminuria (p < 0.001) and retinopathy (p < 0.001) than those without NLD. Our study suggests that children as well as adult diabetics with NLD can be at high risk for nephropathy and retinopathy; NLD can be a clue for diabetic nephropathy and retinopathy.

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Section: Methodsmentioning

confidence: 99%

Necrobiosis Lipoidica Diabeticorum in Children and Adolescents: A Clue for Underlying Renal and Retinal Disease

Verrotti

Chiarelli

Amerio

et al. 1995

Pediatric Dermatology

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“…The presence of initial diabetic nephropathy was evaluated by measuring microalbuminuria. Microalbuminuria was defined as an albumin excretion rate >20 µg/mL, measured by radio immuno assay (RIA) in overnight urine collections, as previously reported (Chiarelli et al 1988). Glycosated haemoglobin (HbA1c) was measured by high-pressure liquid chromatography; serum fructosamine was measured by RIA.…”

Section: Participantsmentioning

confidence: 99%

Visual evoked potentials in young persons with newly diagnosed diabetes: a long‐term follow‐up

Verrotti

Lobefalo

Trotta

et al. 2000

Develop Med Child Neuro

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To evaluate the presence of electrophysiological abnormalities in the visual function of young persons with diabetes, visual evoked potentials were recorded, in basal conditions and after photostress, in 30 patients with newly diagnosed insulin‐dependent diabetes mellitus. Their mean age was 17.6 years (3.6 SD), and their glycosated haemoglobin (HbA1c) was 9.4% (1.6 SD). Thirty healthy age‐ and sex‐matched individuals were evaluated as the control group. This study showed that the P100 latency was significantly delayed in patients with diabetes compared with the control group (p<0.01), while the N75 to P100 amplitude was similar in both groups. These measurements were repeated after 6 months, when all participants with diabetes had achieved good metabolic control (HbA1c 7.2% [1.5 SD]). At this second evaluation a complete normalisation of all parameters was observed. These findings suggest that early functional abnormalities of the optic nerve can be detected at onset of diabetes, and that glycaemic control reverses these abnormalities.

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“…23 C4 serum levels have previously been shown to be lower in diabetic patients than in controls, and low C4 has been suggested to predispose to type 1 diabetes. 24,25 However, in our records, we cannot discriminate whether the patients had type 1 or type 2 diabetes. In most of the patient groups, we observed a trend toward low C4B GCN, except for patients with hypertension and also in the group pooled as 'other' diseases.…”

Section: Discussionmentioning

confidence: 84%

Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney

Bay

Schejbel

Madsen

et al. 2013

Kidney International

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Complement C4 is a central component of the classical and the lectin pathways of the complement system. The C4 protein exists as two isotypes C4A and C4B encoded by the C4A and C4B genes, both of which are found with varying copy numbers. Deposition of C4 has been implicated in kidney graft rejection, but a relationship between graft survival and serum C4 concentration as well as C4 genetic variation has not been established. We evaluated this using a prospective study design of 676 kidney transplant patients and 211 healthy individuals as controls. Increasing C4 gene copy numbers significantly correlated with the C4 serum concentration in both patients and controls. Patients with less than four total copies of C4 genes transplanted with a deceased donor kidney experienced a superior 5-year graft survival (hazard ratio 0.46, 95% confidence interval: 0.25-0.84). No significant association was observed in patients transplanted with a living donor. Thus, low C4 copy numbers are associated with increased kidney graft survival in patients receiving a kidney from a deceased donor. Hence, the degree of ischemia may influence the clinical impact of complement.

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Low serum C4 concentrations in type-1 diabetes mellitus

Cited by 22 publications

References 10 publications

Necrobiosis Lipoidica Diabeticorum in Children and Adolescents: A Clue for Underlying Renal and Retinal Disease

Necrobiosis Lipoidica Diabeticorum in Children and Adolescents: A Clue for Underlying Renal and Retinal Disease

Visual evoked potentials in young persons with newly diagnosed diabetes: a long‐term follow‐up

Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney

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