Low Serum Cobalamin is a Risk Factor for Gestational Diabetes

Butt, Ambreen; Malik, Uzma; Waheed, Khadija; Khanum, Amna; Firdous, Samar; Ejaz, Sara; Randhawa, Fawad Ahmad; Shakoori, Tania Ahmed

doi:10.17582/journal.pjz/2017.49.6.1963.1968

Cited by 8 publications

(11 citation statements)

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“…A previous study by Ambreenet al 2017 [20] reported hypovitaminosis in 67% of GDM cases and 39% in control the findings are in full agreement with the present study. A previous retrospective study from UK reported severe hypovitaminosis B12 in GDM cases compared to non-GDM pregnant women.…”

Section: Discussionsupporting

confidence: 93%

Frequency of Hypovitaminosis B12 in Pregnant Women with Gestational Diabetes Mellitus

Rizwan¹,

Robeen²,

Ahmad³

et al. 2021

PJMHS

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Objective: To determine the frequency of hypovitaminosis B12 in pregnant females presented with gestational diabetes mellitus. Study Design: Retrospective study Place and Duration: The department of Gynaecology and Obstetrics, Category A Hospital, Batkhela Malakand and Muhammad Teaching Hospital, Peshawarfor the duration of six months from October 2020 to March 2021. Methodology: Total 190 pregnant women (95 GDM, 95 non-GDM) were enrolled in this study. Patient’s ages were ranging between 18 to 40 years. Detailed demographics including age, gestational age, body mass index (BMI), and gravidty were recorded after taking informed written consent. Blood samples were taken from all the patients for measuring vitamin B12 status. Hypovitaminosis B12 was defined as <300 pg/ml. Data was analyzed by SPSS 24.0. Results: Mean age of patients was 32.46±6.82 years. Mean BMI was 26.24±2.34 kg/m2. Mean gestational age was 34.56±2.18 weeks. 105 (55.26%) women were multigravida. 80 (42.11%) patients had vitamin B12 level <300 pg/ml. Patients with GDM had high rate of vitaminosis B12 deficiency as compared to non-GDM patients (65.26% Vs 18.95%). A significant association was observed between GDM and hypovitaminosis B12 with p-value <0.0001. Conclusion: Vitamin B12 deficiency was significantly associated with gestational diabetes mellitus with frequency of 65.26%. Keywords: Vitaminosis B12, Gestational Diabetes Mellitus, Pregnancy

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Section: Discussionsupporting

confidence: 93%

Frequency of Hypovitaminosis B12 in Pregnant Women with Gestational Diabetes Mellitus

Rizwan¹,

Robeen²,

Ahmad³

et al. 2021

PJMHS

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“…The findings of low serum cobalamin are in agreement with previous studies. 7,13,[16][17][18] The Milman et al 16 conducted a longitudinal study on the cobalamin levels among pregnant women and proved low cobalamin in normal pregnancies.…”

Section: Discussionmentioning

confidence: 99%

“…Poikilocytosis, anisocytosis, ovalocytosis, hypersegmented neutrophils and pancytopenia may occur. 12,13 Fetus may develop intrauterine growth retardation, fatty liver disease and poor mental development due to defective myelination in the central nervous system. Such babies are prone to developing a multitude to chronic diseases in future such diabetes mellitus (DM), depression, cardiovascular disorders and even cancer.…”

Section: Introductionmentioning

confidence: 99%

“…Such babies are prone to developing a multitude to chronic diseases in future such diabetes mellitus (DM), depression, cardiovascular disorders and even cancer. 12 Currently, the issue of vitamin cobalamin deficiency and GDM has been hotly hinted in medical literature 12,13 , hence there is a need to explore this association of Vitamin cobalamin and GDM in our indigenous population. The present study was planned to explore the Vitamin cobalamin status in Pregnant Women with Gestational Diabetes mellitus presenting at our tertiary care hospital.…”

Section: Introductionmentioning

confidence: 99%

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Serum cobalamin status of pregnant women suffering from gestational diabetes mellitus.

Fatima

Saeed

Hasnny

et al. 2020

TPMJ

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Objectives: Determining serum cobalamin levels in Pregnant Women suffering from Gestational Diabetes mellitus (GDM) presenting at our tertiary care hospital. Study Design: Case control study. Setting: Department of Gynecology and Medicine, SMBB Medical College Layari General Hospital Karachi. Period: January 2016 to April 2017. Material & Methods: Sample of 100 pregnant women in 2nd and 3rd trimester was selected into; 50 controls and 50 GDM cases through convenient sampling. GDM was defined as pregnant women with fasting blood sugar ≥100 mg/dL. 5 ml blood was collected; 3 ml put into EDTA tubes for complete blood counts and 2 ml for sera. Blood glucose was estimated by hexokinase method, HbA1c by colorimetric method and cobalamin by ECLIA assay method. SPSS software 21.0 (IBM, Inc USA) was used for data analysis using Student t-test and Chi-square test (P ≤ 0.05). Results: Age of control was 30.43±1.49 years and 29.95±1.27 years in cases. Gestational age was 33.67±2.69 weeks in controls and 34.75±2.53 weeks in cases. Control and cases shows serum cobalamin levels of 316.34± 113.77 pg/ml and 253.5±121.32 pg/ml respectively (P=0.009). Serum cobalamin deficiency was noted in 68% of cases and 40% of controls (P<0.05). Glycemic control was bad in majority of cases. Serum cobalamin shows inverse correlation with random blood glucose, fasting blood glucose and Glycated HbA1. Conclusion: We found low serum cobalamin levels in pregnant women suffering from gestational diabetes mellitus that showed inverse correlation with random and fasting blood glucose and glycemic control.

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“…Proper diagnosis and good laboratory practices can become best management tools to treat such type of condition [19]. Number of people in our country had over financial burden, so in this case cost-effective laboratory tests and supplements can reduce the burden to hypertension from the pregnant ladies [20]. So, current study was design to ensure the evaluation of total platelet count during pregnancy and other gestational condition at tertiary care hospital of Sindh.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Platelet Counts in the Normal Pregnancy and other Gestational Conditions at Tertiary Care Hospital of Sindh

Palwasha¹,

Bhatti

Gul

et al. 2021

JPRI

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Background: During gestational period, the most common disorder is hypertension that directly affects the gestation. The frequency of gestational hypertension is increasing day by day and ultimately the pressure is developed on the endothelial wall. Gestational hypertension mostly reduces the platelet counts. Aim of Study: The major theme of this research is evaluating the count of platelet during pregnancy and other gestational conditions. Methodology: A Retrospective research was carried out for the period of 06 months at Gynae and Obstetrics ward at tertiary care hospital of Sindh, Pakistan. Total 104 females were selected with different gestational age and trimester. A questionnaire was filled by all participants that were comprised of demographic data and gestational conditions such as preeclampsia, eclampsia, parity and seizure episodes. Females with highest risk factors diseases such as Diabetes, Hepatic disorder, Anemia, renal disorder and cardio vascular disease were not included in our research. Blood samples were collected from all selected participants for proper platelet count and data was compared with normal ranges of platelet count among the pregnant females. Data was analyzed by using statistical software 24.00 versions. Results: It was observed that 49 patients were having normal pregnancy, 32 had preeclampsia and 23 had eclampsia. 38 participants were first timer & 52 were having second time parity. 58 participants had 2nd trimester of pregnancy. According to condition of anemia, 27 had severe anemic condition whereas 43 had moderate anemic condition. 49 participants had reduced level of platelet count and 17 had very low platelet count. Severity of gestation can be managed through proper management and physician instructions. Hypertension was measured through severity scale, 29 patients had moderate level of hypertension and 22 had severe level of hypertension. 19 participants had very abnormal level of blood count. Conclusion: It was concluded that proper diagnostic test should be conducted on time for proper management of reduced platelet count and there should be proper mass counseling should be conducted in order to overcome the deficiency of platelet count. There should be proper diet and exercise during pregnancy that can manage the condition of hypertension. Severity of gestation can be managed through proper management and physician instructions.

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Low Serum Cobalamin is a Risk Factor for Gestational Diabetes

Cited by 8 publications

References 0 publications

Frequency of Hypovitaminosis B12 in Pregnant Women with Gestational Diabetes Mellitus

Frequency of Hypovitaminosis B12 in Pregnant Women with Gestational Diabetes Mellitus

Serum cobalamin status of pregnant women suffering from gestational diabetes mellitus.

Evaluation of Platelet Counts in the Normal Pregnancy and other Gestational Conditions at Tertiary Care Hospital of Sindh

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