Low serum osteocalcin levels are correlated with left ventricular systolic dysfunction and cardiac death in Chinese men

Abstract

Osteocalcin is a newly identified type of cytokine secreted by osteoblasts, which has an endocrine function, mediates energy and glycol-lipid metabolism, and is closely related to cardiovascular diseases. In this study, we investigated the value of serum osteocalcin levels in predicting left ventricular systolic dysfunction and cardiac death. A total of 258 patients in the Department of Cardiology were included. Two-dimensional echocardiography was performed in all the subjects. The cardiac death of subjects occurring with a median follow-up of 4.6 years was informed via phone calls or the electronic medical records. The serum osteocalcin levels were measured using electrochemiluminescent immunoassay. We found that the median left ventricular ejection fractions (LVEFs) were 62% in men and 63% in women. In the men with a LVEF > 62%, the serum osteocalcin levels were significantly higher than in those with LVEF ≤ 62% (P = 0.042), whereas this difference was absent in the women. Both the serum osteocalcin (β = 0.095, P = 0.028) and serum N-terminal pro-brain natriuretic peptide (NT-pro-BNP; β = -0.003, P < 0.01) levels remained independently significantly correlated with LVEF in the men but not in the women. Receiver operating characteristic (ROC) analyses of the men revealed that the serum osteocalcin (P = 0.007), serum NT-pro-BNP (P = 0.018) and serum osteocalcin + NT-pro-BNP (P < 0.01) levels were all significant in identifying left ventricular systolic dysfunction at baseline, but the pairwise comparisons of the three areas under the curves (AUCs) were all non-significant. The men in the lower osteocalcin level group at baseline suffered a greater risk of future cardiac death than those in the higher osteocalcin level group, whereas the result for NT-pro-BNP exhibited the opposite pattern. In conclusion, lower serum osteocalcin levels in the men could identify left ventricular systolic dysfunction and cardiac death in a manner that was not inferior to high serum NT-pro-BNP levels.

The Value of Echocardiography Combined with NT-pro BNP Level in Assessment and Prognosis of Diastolic Heart Failure

“…At the same time, this study through multivariate logistic regression analysis found that NT-pro BNP was a risk factor for MACE and NYHA class in patients, which means that NT-pro BNP is can be the basis for grading and prognosis of patients with DHF. However, there are some studies have shown that men have lower NT-pro BNP levels than women [ 16 ]. Renal dysfunction leads to sodium-water retention, resulting in increased cardiac pressure load, and finally increased left ventricular wall pressure, resulting NT-pro BNP release [ 17 ].…”

The Association Between Osteocalcin and C-Reactive Protein; A Relation of Bone with Inflammation: A Systematic Review and Meta-Analysis

“…Several studies have documented that the concentration of serum OC was lower among patients as compared to healthy controls [43,46]. In a case-control study, levels of serum OC were lower among patients with fatty liver [46], diabetes [68], and cardiovascular disease [69]. In addition, studies on populations with inflammatory diseases such as rheumatoid arthritis reported a positive association between OC and CRP levels [70].…”

Calcification markers and long-term outcomes of coronary artery bypass grafting

“…Данные клинического исследования показали, что уровни остеокальцина в крови коррелируют с функцией сердца. Авторы сообщили о взаимосвязи между уровнем остеокальцина в крови и фракцией выброса левого желудочка, обнаружив, что более низкие уровни остеокальцина в крови коррелировали с более высоким риском систолической дисфункции левого желудочка [18]. Опубликованы результаты, свидетельствующие о том, что кальций (кальциноз) коронарных артерий независимо ассоциирован с уровнем в крови остеокальцина [11].…”