Low serum PON1 activity: An independent risk factor for coronary artery disease in North–West Indian type 2 diabetics

Gupta, Nidhi; Binu, K.; Singh, Surjit; Maturu, Venkata Nagarjuna; Sharma, Yash Paul; Bhansali, Anil; Gill, Kiran Dip

doi:10.1016/j.gene.2012.01.091

Cited by 28 publications

(19 citation statements)

References 42 publications

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“…A recent meta-analysis [148] of 35 studies showed no conclusive relationship of PON1 polymorphisms with either CAD or MI. Studies looking specifically at CAD or MI in T2DM subjects [84, 143-146] yielded the same arguable conclusions (Table 6 ).…”

Section: Polymorphisms Of Other Antioxidant System Genesmentioning

confidence: 67%

Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus

Tibaut¹,

Petrovič

2016

CHAMC

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The worldwide increasing prevalence of obesity and sedentary lifestyle is the main cause of the rising incidence of T2DM. Due to chronic macrovascular and microvascular complications, T2DM represent a huge socioeconomic burden in the world. Oxidative stress is a key pathogenic mechanism implicated in diabetic coronary artery disease (CAD). Polymorphisms of oxidative stress genes are known to influence oxidative stress levels and are therefore thought to impact CAD pathogenesis. Identifying higher risk groups would be rational, since it would allow better sample selection and thus better results in antioxidant trials. In this review, we summarize the evidence of oxidative stress gene polymorphisms related to the pathogenesis of CAD. Moreover, we provide a review of antioxidants tested in subjects with CAD.

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Section: Polymorphisms Of Other Antioxidant System Genesmentioning

confidence: 67%

Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus

Tibaut¹,

Petrovič

2016

CHAMC

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“…Gupta et al (2011) found that L-T-G-Q-C and L-T-G-R-G haplotypes (order of SNPs being L55M, -108C/T, -162A/G, Q192R, -909G/ C) were significantly associated with increased risk of CAD in Asian Indians. They also found that L-C-A-R-G, L-C-G-Q-C, L-C-G-R-C, L-T-A-R-C, L-T-A-R-G and L-T-G-Q-C haplotypes appeared to be protective against CAD development in persons with type II diabetes mellitus (Gupta et al, 2012). In a study by Jarvik et al (2003), MQT was the most common 3-locus haplotype in normal controls, followed by LQC.…”

Section: Discussionmentioning

confidence: 93%

“…Previous studies on Asian Indians have focused on two-locus haplotypes, and have not considered the -108 polymorphism (Sanghera et al, 1998;Agrawal et al, 2009). More recently, Gupta et al (2011Gupta et al ( , 2012 have reported their findings on several PON1 gene polymorphisms including the PON1 -108 polymorphism. Earlier, we published our findings on the normal distribution of the alleles of the -108 polymorphism in Asian Indians.…”

Section: Introductionmentioning

confidence: 99%

Two- and three-locus haplotypes of the paraoxonase (PON1) gene are associated with coronary artery disease in Asian Indians

Ahmad

Narang

Venkatraman

et al. 2012

Gene

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“…As shown in Table , eight articles focused on the association of paraoxonase 1 activity and the risk of diabetic macroangiopathy, including 737 cases and 671 controls . The results showed that significant heterogeneity was found ( I 2 = 94.90%, P = .000, Figure A).…”

Section: Resultsmentioning

confidence: 99%

“…Two studies used the same case series, respectively, so the most recent publication was included . Lastly, 36 case‐control studies were included in the meta‐analyses . Thirty‐four publications were written in English, and two were written in Chinese .…”

Section: Resultsmentioning

confidence: 99%

The association between paraoxonase 1 activity and the susceptibilities of diabetes mellitus, diabetic macroangiopathy and diabetic microangiopathy

Zhong

2018

J Cellular Molecular Medi

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We carried out this meta‐analysis to explore the influence of paraoxonase 1 activity on the susceptibility of diabetes mellitus (DM), diabetic macroangiopathy and diabetic microangiopathy. Relevant studies were identified from PubMed, Web of Science and CNKI without language limitation, following the inclusion and exclusion criteria. Statistical analyses were implemented with the STATA 12.0 statistical software. Thirty‐six case‐control studies were included in the meta‐analyses, in which 35 for the association between paraoxonase 1 activity and DM risk, 8 for diabetic macroangiopathy and 7 for diabetic microangiopathy. Paraoxonase 1 activity was significantly associated with the susceptibility of DM in pooled population (SMD = −1.37, 95% CI = −1.79 ∼ −0.96, P = .000), and Asians (SMD = −2.00, 95% CI = −2.56 ∼ −1.44, P = .000), but not in non‐Asians (SMD = −0.44, 95% CI = −0.91 ∼ 0.03, P = .069). However, marked heterogeneity was existed (I2 = 98.10%, P = .000) and subgroup analyses failed to investigate the sources of heterogeneity. Then, meta‐regression was performed and found that ethnicity could explain the observed between‐study heterogeneity (P = .002). Meanwhile, significant associations were found between paraoxonase 1 activity and diabetic macroangiopathy (SMD = −1.06, 95% CI = −1.63 ∼ −0.48, P = .000) and diabetic microangiopathy (SMD = −0.72, 95% CI = −1.32 ∼ −0.13, P = .018). In conclusion, paraoxonase 1 activity plays important roles in the risk of DM, diabetic macroangiopathy and microangiopathy with ethnicity differences. Further studies with large sample and well design are needed to confirm these results.

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Low serum PON1 activity: An independent risk factor for coronary artery disease in North–West Indian type 2 diabetics

Cited by 28 publications

References 42 publications

Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus

Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus

Two- and three-locus haplotypes of the paraoxonase (PON1) gene are associated with coronary artery disease in Asian Indians

The association between paraoxonase 1 activity and the susceptibilities of diabetes mellitus, diabetic macroangiopathy and diabetic microangiopathy

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