Low serum selenium concentration is associated with preeclampsia in pregnant women from Bangladesh

Haque, Md. Mahmodul; Moghal, Md. Mizanur Rahman; Sarwar, Md. Shahid; Anonna, Shamima Nasrin; Akter, Mariyam; Karmakar, Palash; Ahmed, Salma; Sattar, MA; Islam, Mohammad Safiqul

doi:10.1016/j.jtemb.2015.08.002

Cited by 25 publications

(20 citation statements)

References 37 publications

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“…Dhanajaya et al [35], in an Indian study, found a negative correlation between oxidative stress and the severity of preeclampsia. Serum selenium was negatively correlated to gestational age and this is consistent with earlier findings of some previous studies [22,28,36], however, Karita et al [37] reported no significant difference in the selenium level among pregnant Japanese women according to pregnancy trimesters. The finding implies that as gestational age increases serum selenium decreases.…”

Section: Plos Onesupporting

confidence: 90%

“…This finding is also in consonance with the findings of Akinloye et al [20] in Oshogbo South-West Nigeria. These lower selenium levels were also shown in many other similar studies [16,[21][22][23][24]. Farzin et al [25] in Iran found a significantly lower selenium level between the preeclamptic and normotensive pregnant women, although serum selenium levels were within the normal range in both groups.…”

Section: Plos Onesupporting

confidence: 72%

“…This is not surprising since both systolic and diastolic blood pressures were used to define the severity of preeclampsia. Other studies also reported similar findings [20,22]. Dhanajaya et al [35], in an Indian study, found a negative correlation between oxidative stress and the severity of preeclampsia.…”

Section: Plos Onesupporting

confidence: 70%

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Serum selenium levels of pre-eclamptic and normal pregnant women in Nigeria: A comparative study

et al. 2020

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Introduction Trace element selenium, an antioxidant, and peroxynitrite scavenger when incorporated into selenoproteins and enzymes reduce oxidative stress which is implicated in the aetiopathogenesis of pre-eclampsia. A paucity of information exists on the serum selenium levels among pre-eclamptic pregnant women in Nigeria, hence the need for this study. Objective To compare mean serum selenium levels and prevalence of selenium deficiency in preeclamptic pregnant women and their normotensive pregnant controls. Materials and methods A comparative case-control study was carried out at the Department of Obstetrics and Gynaecology, Federal Medical Centre, Owerri, Imo state. Fifty-eight preeclamptic and equal normotensive pregnant controls were matched for age groups, gestational age groups, parity groups, and socioeconomic status had their serum samples analyzed for selenium level using atomic absorption spectrophotometer (ASS). Data analysis was done using the statistical package for social sciences (SPSS) version 20.0. P-value of < 0.05 was considered to be statistically significant. Result Mean serum selenium levels of the preeclamptic women(0.67±0.27μmol/l) was significantly (p<0.001) lower than that of the normotensive controls(1.20±0.46μmol/l). Selenium

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Section: Plos Onesupporting

confidence: 90%

Section: Plos Onesupporting

confidence: 72%

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Serum selenium levels of pre-eclamptic and normal pregnant women in Nigeria: A comparative study

et al. 2020

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“…The studies conducted earlier were mainly animal studies or retrospective studies in humans. Abnormal levels of Se, Fe, Zn, and Cu were found in women with preeclampsia or gestational diabetes mellitus (GDM) [16][17][18]. However, these effects may be due to disorders which have already developed, e.g., increased oxidative stress can increase the consumption of antioxidant elements.…”

Section: Introductionmentioning

confidence: 99%

First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications

Lewandowska

Więckowska

Sajdak³

et al. 2020

Nutrients

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Microelements involved in the oxidative balance have a significant impact on human health, but their role in pregnancy are poorly studied. We examined the relationships between first trimester levels of selenium (Se), iron (Fe), zinc (Zn), and copper (Cu), as well as maternal characteristics and pregnancy results. The data came from a Polish prospective cohort of women in a single pregnancy without chronic diseases. A group of 563 women who had a complete set of data, including serum microelements in the 10–14th week was examined, and the following were found: 47 deliveries <37th week; 48 cases of birth weight <10th and 64 newborns >90th percentile; 13 intrauterine growth restriction (IUGR) cases; 105 gestational hypertension (GH) and 15 preeclampsia (PE) cases; and 110 gestational diabetes mellitus (GDM) cases. The microelements were quantified using mass spectrometry. The average concentrations (and ranges) of the elements were as follows: Se: 60.75 µg/L (40.91–125.54); Zn: 618.50 µg/L (394.04–3238.90); Cu: 1735.91 µg/L (883.61–3956.76); and Fe: 1018.33 µg/L (217.55–2806.24). In the multivariate logistic regression, we found that an increase in Se of 1 µg/L reduces the risk of GH by 6% (AOR = 0.94; p = 0.004), the risk of IUGR by 11% (AOR = 0.89; p = 0.013), and the risk of birth <34th week by 7% (but close to the significance) (AOR = 0.93; p = 0.061). An increase in Fe of 100 µg/L reduces the risk of PE by 27% (AOR = 0.73; p = 0.009). In the multivariable linear regression, we found negative strong associations between prepregnancy BMI, Se (β = −0.130; p = 0.002), and Fe (β = −0.164; p < 0.0001), but positive associations with Cu (β = 0.320; p < 0.000001). The relationships between Se and maternal age (β = 0.167; p < 0.0001), Se and smoking (β = −0.106; p = 0.011) and Cu, and gestational age from the 10–14th week (β = 0.142; p < 0.001) were also found. Secondary education was associated with Zn (β = 0.132; p = 0.004) and higher education was associated with Cu (β = −0.102; p = 0.023). A higher financial status was associated with Fe (β = 0.195; p = 0.005). Other relationships were statistically insignificant. Further research is needed to clarify relationships between first trimester microelements and pregnancy complications. In addition, attention should be paid to lifestyle-related and socioeconomic factors that affect microelement levels.

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“…Selenium is an important constituent that acts as an antioxidant and has some possible metabolic function in terms of treating PE with a certain concentration [110]. Extra Virgin Olive Oil (EVOO), in the form of extra virgin, contains a rich antioxidant tocopherol (Vitamin E) capable of controlling the induction of HSP70 serum levels are not excessive, so the process of apoptosis does not occur excessively, especially PE [111]. A significant effect of EVOO on TGF-β expression in placenta and there was a positive and strong relationship (r=0.494) as well as a very significant relationship (p<0.01) between TGF-β and the serum MDA [112].…”

Section: Hepatic Disease In Pementioning

confidence: 99%

Study of Preeclampsia in Placenta, Kidney, and Hepatic Diseases

Situmorang

Ilyas

2018

Asian J Pharm Clin Res

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Preeclampsia (PE) have a high risk of pregnancy disorder and can cause liver and kidney disease. PE is a dangerous disease in Indonesia with a high risk of cardiovascular death. PE has biomarkers such as proteinuria, blood pressure, dipstick test, renin-angiotensin system, adipsin, calcium/ creatinine (Cr) ratio, albumin/Cr ratio, and uric acid. Apoptosis occurs in the placenta’s PE, where trophoblasts invade and overhaul the uterine spiral artery in the epidermal growth factor signaling system, and the expression of miRNA in PE is targeting genes in a variety of pathophysiological processes can cause kidney and hepatic disease. In this review, we will discuss role of HSP, miRNA, Immunology cell and the risk of kidney and hepatic disease of patient of Preeclampsia.

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Low serum selenium concentration is associated with preeclampsia in pregnant women from Bangladesh

Cited by 25 publications

References 37 publications

Serum selenium levels of pre-eclamptic and normal pregnant women in Nigeria: A comparative study

Serum selenium levels of pre-eclamptic and normal pregnant women in Nigeria: A comparative study

First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications

Study of Preeclampsia in Placenta, Kidney, and Hepatic Diseases

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