2022
DOI: 10.1371/journal.pone.0276481
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Low serum uromodulin levels and their association with lupus flares

Abstract: Background Only two previous studies in systemic lupus erythematosus (SLE) patients have identified that the blood concentrations of uromodulin are lower in nephritis. However, none of them had evaluated whether a low serum uromodulin adjusted by the glomerular filtration rate (sUromod/eGFR index) contributed to identify patients in risk of lupus nephritis (LN) using multivariable models. Aim Therefore, this study aimed two objectives to evaluate the association between low serum uromodulin levels and low sU… Show more

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Cited by 3 publications
(6 citation statements)
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“…In contrast to other studies [4,202], diminished serum uromodulin concentrations showed a correlation with proteinuria severity. The correlation between lower serum uromodulin levels and proteinuria intensity remained evident even after adjusting for the eGFR using the serum uromodulin/eGFR index [200]. In conclusion, low serum uromodulin levels adjusted by eGFR could potentially serve as a marker associated with renal flares in patients with SLE.…”
Section: Lupus Nephritismentioning
confidence: 82%
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“…In contrast to other studies [4,202], diminished serum uromodulin concentrations showed a correlation with proteinuria severity. The correlation between lower serum uromodulin levels and proteinuria intensity remained evident even after adjusting for the eGFR using the serum uromodulin/eGFR index [200]. In conclusion, low serum uromodulin levels adjusted by eGFR could potentially serve as a marker associated with renal flares in patients with SLE.…”
Section: Lupus Nephritismentioning
confidence: 82%
“…However, in the subsequent multivariable analysis, where serum uromodulin was adjusted for eGFR, the risk of renal flare based on the rSLEDAI was found to be 2.94, independent of other variables. The risk further rose to 4.27 when a patient with a flare had a SLICC renal disease activity score ≥ 5 [200]. Scherberich et al provided further support for these findings through their analysis of patients with CKD.…”
Section: Lupus Nephritismentioning
confidence: 90%
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“…Serum uromodulin was lower in patients with renal activity and may be predictive of the risk of a renal flare (12). Similarly, beta 2-microglobulin correlated with BUN, serum creatinine and 24-h urinary protein.…”
Section: Biomarkersmentioning
confidence: 86%