Low shear stress induces inflammatory response via CX3CR1/NF-κB signal pathway in human umbilical vein endothelial cells

Huang, Haozhong; Ren, Peile; Zhao, Yiwei; Weng, Huimin; Jia, Chunsen; Yu, Fangming; Nie, Yongzhan

doi:10.1016/j.tice.2023.102043

Cited by 5 publications

(1 citation statement)

References 31 publications

(25 reference statements)

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“…Oscillatory shear stress causes mitochondrial dysfunction, producing excessive ROS and inflammation in vascular ECs, followed by mitochondrial-induced inflammation [197]. It promotes an inflammatory environment [204] and directly influences plaque formation and stability [205]. In line with these findings, oscillatory shear stress enhances fission but does not support mitophagy in mouse aortic ECs [203].…”

Section: Endothelial Mitochondrial Dysfunction In Atherosclerosis: a ...mentioning

confidence: 83%

Mitochondrial Dysfunction in Endothelial Progenitor Cells: Unraveling Insights from Vascular Endothelial Cells

Kulovic-Sissawo,

Tocantins,

Diniz

et al. 2024

Biology

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Endothelial dysfunction is associated with several lifestyle-related diseases, including cardiovascular and neurodegenerative diseases, and it contributes significantly to the global health burden. Recent research indicates a link between cardiovascular risk factors (CVRFs), excessive production of reactive oxygen species (ROS), mitochondrial impairment, and endothelial dysfunction. Circulating endothelial progenitor cells (EPCs) are recruited into the vessel wall to maintain appropriate endothelial function, repair, and angiogenesis. After attachment, EPCs differentiate into mature endothelial cells (ECs). Like ECs, EPCs are also susceptible to CVRFs, including metabolic dysfunction and chronic inflammation. Therefore, mitochondrial dysfunction of EPCs may have long-term effects on the function of the mature ECs into which EPCs differentiate, particularly in the presence of endothelial damage. However, a link between CVRFs and impaired mitochondrial function in EPCs has hardly been investigated. In this review, we aim to consolidate existing knowledge on the development of mitochondrial and endothelial dysfunction in the vascular endothelium, place it in the context of recent studies investigating the consequences of CVRFs on EPCs, and discuss the role of mitochondrial dysfunction. Thus, we aim to gain a comprehensive understanding of mechanisms involved in EPC deterioration in relation to CVRFs and address potential therapeutic interventions targeting mitochondrial health to promote endothelial function.

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Section: Endothelial Mitochondrial Dysfunction In Atherosclerosis: a ...mentioning

confidence: 83%

Mitochondrial Dysfunction in Endothelial Progenitor Cells: Unraveling Insights from Vascular Endothelial Cells

Kulovic-Sissawo,

Tocantins,

Diniz

et al. 2024

Biology

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Remodeling of the cardiovascular hemodynamic environment by lower limb heat exposure: A computational fluid dynamic study

Yan

et al. 2023

Computer Methods and Programs in Biomedicine

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Role of the portal system in liver regeneration: From molecular mechanisms to clinical management

Xu,

Qiu,

Wang

et al. 2024

Liver Research

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Low shear stress induces inflammatory response via CX3CR1/NF-κB signal pathway in human umbilical vein endothelial cells

Cited by 5 publications

References 31 publications

Mitochondrial Dysfunction in Endothelial Progenitor Cells: Unraveling Insights from Vascular Endothelial Cells

Mitochondrial Dysfunction in Endothelial Progenitor Cells: Unraveling Insights from Vascular Endothelial Cells

Remodeling of the cardiovascular hemodynamic environment by lower limb heat exposure: A computational fluid dynamic study

Role of the portal system in liver regeneration: From molecular mechanisms to clinical management

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