Low-Spatial-Frequency Channels and the Spatial Frequency-Doubling Illusion

Rosli, Yanti; Bedford, Suzanne; Maddess, Ted

doi:10.1167/iovs.08-1810

Cited by 19 publications

(17 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These produce the FD percept across the field. 16 A Bayesian threshold estimation strategy is applied to provide thresholds with normal attenuation values numerically comparable to those attained using standard forms of static perimetry. 17 VF loss is typically seen at an earlier clinical stage with Matrix than with more traditional automated static perimetry that utilize focal light stimuli flashed for 0.2 seconds in an illuminated bowl (as used in our prior study).…”

Section: Methodsmentioning

confidence: 99%

Refined Frequency Doubling Perimetry Analysis Reaffirms Central Nervous System Control of Chronic Glaucomatous Neurodegeneration

Reilly

Villarreal

Maddess

et al. 2015

Trans. Vis. Sci. Tech.

Self Cite

View full text Add to dashboard Cite

Citation: Reilly MA, Villarreal A, Maddess T, Sponsel WE. Refined frequency doubling perimetry analysis reaffirms central nervous system control of chronic glaucomatous neurodegeneration. Trans Vis Sci Tech. 2015;4(3):7, doi:10.1167/tvst.4. 3.7 Purpose: Refined analysis of frequency doubling perimetric data was performed to assess binocular visual field conservation in patients with comparable degrees of bilateral glaucomatous damage, to determine whether unilateral visual field loss is random, anatomically symmetric, or non-random in relation to the fellow eye.Methods: Case control study of 41 consecutive patients with bilaterally mild to severe glaucoma; each right eye visual field locus was paired with randomly-selected coisopteric left eye loci, performing 690,000 (10,000 complete sets of 69 loci) such iterations per subject. The potential role of anatomic symmetry in bilateral visual field conservation was also assessed by pairing mirror-image loci of the right-and left-eye fields. The mean values of the random co-isopteric and the symmetric mirror pairings were compared with natural point-for-point pairings of the two eyes by paired t-test.Results: Mean unilateral Matrix threshold across the entire 30-degree visual field were 17.0 dB left and 18.4 dB right (average 17.7). The better of the naturally paired concomitant loci yielded binocular equivalent mean bilateral Matrix threshold of 20.9 dB, 1.6 dB higher than the population mean of the 690,000 coisopteric pairings (t ¼ À10.4; P , 10 À12 ). Thus, a remarkable natural tendency for conservation of the binocular Matrix visual field was confirmed, far stronger than explicable by random chance. Symmetric pairings of precise mirror-image loci also produced values higher than random co-isopteric pairings (D 1.1 dB; t ¼ À4.0; P ¼ 0.0004).Conclusions: Refined data analysis of paired Matrix visual fields confirms the existence of a natural optimization of binocular visual function in severe bilateral glaucoma via interlocking fields that could only be created by CNS involvement. The disparity of paired Matrix threshold values at mirror-image loci was also highly nonrandom and quantitatively inverse from the expected if anatomic symmetry factors were merely passively contributing systematically to the compensatory binocular Matrix effect.Translational Relevance: The paired eyes and brain are reaffirmed to function as a unified system in the progressive age-related neurodegenerative condition chronic open angle glaucoma, maximizing the binocular visual field. Given the extensive homology of this disorder with other age-related neurodegenerations, it is reasonable to assume that the brain will similarly resist simultaneous bilateral loss of paired functional zones in both hemispheres in diseases like Alzheimer's and Parkinson's disease. Glaucomatous eyes at all stages of the disease appear to provide a highly accessible paired-organ study model for developing therapeutics to optimize conservation of function in neurodegenerative disorders.

show abstract

Section: Methodsmentioning

confidence: 99%

Refined Frequency Doubling Perimetry Analysis Reaffirms Central Nervous System Control of Chronic Glaucomatous Neurodegeneration

Reilly

Villarreal

Maddess

et al. 2015

Trans. Vis. Sci. Tech.

Self Cite

View full text Add to dashboard Cite

show abstract

“…3 The gratings modulated at the temporal and spatial frequencies described here exhibit the FD illusion for VF locations like those used here. 22 Importantly, the selected frequencies in the stimulus band mean that any frequencies generated by second order interactions between regions are separate from the second harmonic and noise frequencies. 2,3 Testing Conditions Stimuli were presented at three different viewing distances, 16, 32, and 128 cm (Figs.…”

Section: Stimulus Frequencies and Data Acquisitionmentioning

confidence: 99%

Effect of Contrast, Stimulus Density, and Viewing Distance on Multifocal Steady-State Visual Evoked Potentials (MSVs)

Abdullah

Aldahlawi

Rosli

et al. 2012

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

The response per unit area indicated that cortical folding diminishes responses to larger stimuli. Viewing distance did not greatly affect response amplitude. This suggested that we can use similar, but scaled, stimuli to study central and peripheral disease. The rapidly saturating contrast responses imply that there would be nothing lost from testing at contrasts as low as 20% given that higher, saturating contrasts might mask visual field defects.

show abstract

“…2,3,8 The postulated link between illusory frequency doubling and magnocellular Y-cells has also been questioned by Zeppieri and colleagues 9 based on the finding that the perceived frequency is not always double that of the stimulus grating but can attain a range of fractional frequencies. Also, Rosli et al 10 using factor analysis found that three factors were able to account for 79.3% of the variance in the probability in seeing frequency doubling in highcontrast gratings. This does not seem to indicate that the percept of frequency doubling is linked uniquely to the magnocellular system.…”

Section: B C Skottun and J R Skoylesmentioning

confidence: 99%

The Frequency Doubling Illusion and Testing of Magnocellular Sensitivity

Skottun

Skoyles

2011

Neuro-Ophthalmology

View full text Add to dashboard Cite

The frequency doubling illusion has been claimed to be a useful test of magnocellular integrity. This claim is examined. It is found that since the temporal frequency of the stimuli is very high, it is plausible that they are detected by magnocellular neurons. This, however, does not make frequency doubling by itself into an appropriate test of magnocellular sensitivity. This is because it involves testing sensitivity under only one stimulus condition and so does not allow magnocellular deficits to be differentiated from general visual impairments. Further limitations on the use of the frequency doubling illusion to assess magnocellular sensitivity are also discussed.

show abstract

Low-Spatial-Frequency Channels and the Spatial Frequency-Doubling Illusion

Abstract: The results support earlier reports, that there are several low-spatial-frequency channels below 1 cyc/deg in the periphery. The results may have implications for the FDT and matrix perimeters.

Cited by 19 publications

References 34 publications

Refined Frequency Doubling Perimetry Analysis Reaffirms Central Nervous System Control of Chronic Glaucomatous Neurodegeneration

Refined Frequency Doubling Perimetry Analysis Reaffirms Central Nervous System Control of Chronic Glaucomatous Neurodegeneration

Effect of Contrast, Stimulus Density, and Viewing Distance on Multifocal Steady-State Visual Evoked Potentials (MSVs)

The Frequency Doubling Illusion and Testing of Magnocellular Sensitivity

Contact Info

Product

Resources

About