Low-Temperature Plasma for Biology, Hygiene, and Medicine: Perspective and Roadmap

Laroussi, Mounir; Bekeschus, Sander; Keidar, Michael; Bogaerts, Annemie; Fridman, Alexander; Lü, Xin; Ostrikov, Kostya Ken; Hori, Masaru; Stapelmann, Katharina; Miller, Vandana; Reuter, Stephan; Laux, Christophe O.; Mesbah, Ali; Walsh, James L.; Jiang, Chunqi; Thagard, Selma Mededovic; Tanaka, Hiromasa; Liu, Da Wei; Yan, Dayun; Yusupov, Maksudbek

doi:10.1109/trpms.2021.3135118

Cited by 93 publications

(72 citation statements)

References 289 publications

(302 reference statements)

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“…The use of plasma active liquids shows potential applications in cancer treatment, their cytotoxic effect on GBM cells was also assessed. [ 35–37 ] They have the ability to penetrate targets, where direct plasma treatment cannot be applied as well as being a safer option than direct plasma as no close exposure to high voltage, is needed. [ 38 ] To determine whether the same combinatory effect would be observed when US is combined with PAM or whether the synergic effect observed is mainly based on RONS, PAM was added to the cells followed by US treatment.…”

Section: Discussionmentioning

confidence: 99%

Synergistic cytotoxicity from cold atmospheric plasma and ultrasound in glioma cells

Carvalho

Scally

Tiwari

et al. 2022

Plasma Processes & Polymers

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The aim of this study was to investigate whether sonoporation of cancer cells using ultrasound (US) technology could enhance the anticancer effects of cold atmospheric plasma. US‐induced transient sonoporation of cancer cells with little to no cytotoxicity observed on the cell lines tested. Synergistic effects of US were observed when combined with both direct and indirect cold atmospheric plasma. These cytotoxic effects were dependent on reactive species production. To the best of our knowledge that is the first time that the effects of those two nonthermal technologies were evaluated in cancer cells, demonstrating a promising combined strategy for cancer therapies, particularly for those with penetration limitations, such as glioblastoma.

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Section: Discussionmentioning

confidence: 99%

Synergistic cytotoxicity from cold atmospheric plasma and ultrasound in glioma cells

Carvalho

Scally

Tiwari

et al. 2022

Plasma Processes & Polymers

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“…The effects of PAW on the fertigation of plants (i.e., the injection of fertilizers and chemicals into an irrigation system) are mentioned in review [ 46 ]. The exposure of seeds to hydrogen peroxide (H 2 O 2 ) and nitric oxides (NO x ) may trigger changes in plant hormones, promoting germination.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Effect of Plasma-Activated Water and Artificially Prepared Plasma-Activated Water on Wheat Grain Properties

Jirešová

Scholtz

Julák

et al. 2022

Plants

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Recently, much attention has been paid to the use of low-temperature plasmas and plasma-activated water (PAW) in various areas of biological research. In addition to its use in medicine, especially for low-temperature disinfection and sterilization, a number of works using plasma in various fields of agriculture have already appeared. While direct plasma action involves the effects of many highly reactive species with short lifetimes, the use of PAW involves the action of only long-lived particles. A number of articles have shown that the main stable components of PAW are H2O2, O3, HNO2, and HNO3. If so, then it would be faster and much more practical to artificially prepare PAW by directly mixing these chemicals in a given ratio. In this article, we review the literature describing the composition and properties of PAW prepared by various methods. We also draw attention to an otherwise rather neglected fact, that there are no significant differences between the action of PAW and artificially prepared PAW. The effect of PAW on the properties of wheat grains (Triticum aestivum L.) was determined. PAW exposure increased germination, shoot length, and fresh and dry shoot weight. The root length and R/S length, i.e., the ratio between the underground (R) and aboveground (S) length of the wheat seedlings, slightly decreased, while the other parameters changed only irregularly or not at all. Grains artificially inoculated with Escherichia coli were significantly decontaminated after only one hour of exposure to PAW, while Saccharomyces cerevisiae decontamination required soaking for 24 h. The differences between the PAW prepared by plasma treatment and the PAW prepared by artificially mixing the active ingredients, i.e., nitric acid and hydrogen peroxide, proved to be inconsistent and statistically insignificant. Therefore, it may be sufficient for further research to focus only on the effects of artificial PAW.

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“…The low-temperature, non-equilibrium atmospheric pressure plasmas have attracted increasing interest as simple and less expensive plasma sources operating in open space for applications in biology, medicine, agriculture, and the food industry [1][2][3][4][5][6][7][8][9][10]. Various types of atmospheric pressure plasma sources were developed for such applications.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of 2.45 GHz Surface-Wave-Sustained Argon Discharge for Bio-Medical Applications

Benova

Marinova

Tafradjiiska-Hadjiolova

et al. 2022

Applied Sciences

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Cold atmospheric plasma (CAP) applications in various fields, such as biology, medicine and agriculture, have significantly grown during recent years. Many new types of plasma sources operating at atmospheric pressure in open air were developed. In order to use such plasmas for the treatment of biological systems, plasma properties should fulfil strong requirements. One of the most important is the prevention from heating damage. That is why in many cases, the post-discharge region is used for treatment, but the short living particles in the active discharge zone and reactions with them are missed in that case. We use the active region of surface-wave-sustained argon plasma for biological systems treatment. The previous investigations showed good bactericidal, virucidal, seeds germination and decontamination effects at a short treatment time, but the discharge conditions for bio-medical applications need specific adjustment. A detailed theoretical and experimental investigation of the plasma characteristics and their possible optimization in order to meet the requirements for bio-medical applications are presented in this paper. The length of the plasma torch, the temperature at the treatment sample position and the microwave radiation there are estimated and optimized by the appropriate choice of discharge tube size, argon flow rate and microwave power.

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Low-Temperature Plasma for Biology, Hygiene, and Medicine: Perspective and Roadmap

Cited by 93 publications

References 289 publications

Synergistic cytotoxicity from cold atmospheric plasma and ultrasound in glioma cells

Synergistic cytotoxicity from cold atmospheric plasma and ultrasound in glioma cells

Comparison of the Effect of Plasma-Activated Water and Artificially Prepared Plasma-Activated Water on Wheat Grain Properties

Characteristics of 2.45 GHz Surface-Wave-Sustained Argon Discharge for Bio-Medical Applications

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