Low testosterone level in middle-aged male patients with coronary artery disease

Hu, Xiaorong; Li, Rui; Zhu, Tongjian; Xia, Hao; Yang, Xiaoqin; Wang, Xiaohong; Liu, Huafen; Lu, Zhibing; Jiang, Hong

doi:10.1016/j.ejim.2011.08.016

Cited by 57 publications

(53 citation statements)

References 18 publications

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“…In a population study performed on 87 Chinese middle-aged men, the serum T levels were found to be lower among CAD patients and were also negatively correlated with their Gensini scores [5]. Zhao et al [6] conducted their study in China as well, including over 102 patients and 99 healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Akishita et al [4] demonstrated that a low androgen level is a predictor of cardiovascular events in Japanese men with cardiovascular risk factors. Similarly, Hu et al [5] and Zhao et al [6] revealed androgen deficiency to be a risk factor for the development of CAD in Chinese men. In a study conducted in a Swedish population, Ohlsson et al [7] concluded that high T levels predicted a reduced 5-year risk of cardiovascular events in elderly men.…”

Section: Introductionmentioning

confidence: 99%

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Cardiac surgery The association between serum testosterone levels and coronary artery disease in middle-aged men

Durukan¹,

Gürbüz²,

Tanalp³

et al. 2013

kitp

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StreszczenieWprowadzenie: Związek pomiędzy chorobą wieńcową a stę-żeniami androgenów w surowicy został stwierdzony przez autorów różnych badań populacyjnych. Skala Gensiniego ocenia stopień zwężeń wieńcowych, biorąc pod uwagę ich umiejscowienie. Celem niniejszej pracy było zbadanie związku pomiędzy surowiczym stężeniem testosteronu a obecnością choroby wień-cowej i jej nasileniem (według skali Gensiniego) u mężczyzn w średnim wieku. Materiał i metody: Pomiędzy październikiem 2011 r. a kwietniem 2012 r. do badania włączono 124 mężczyzn w średnim wieku (40-59 lata), u których stwierdzono bądź podejrzewano chorobę wieńcową. Wszyscy chorzy zostali poddani angiografii wieńcowej i obliczono dla nich wynik w skali Gensiniego. Zmierzono również całkowite stężenia testosteronu. Wyniki: Średni wynik pacjentów w skali Gensiniego wyniósł 44,11 ±39,08. Średnie stężenie testosteronu w plazmie wynosiło 3,51 ±1,39 ng/ml. Nie wykryto korelacji pomiędzy nasileniem choroby wieńcowej a surowiczym stężeniem testosteronu (r = -0,161, p > 0,05). Kiedy porównano pacjentów z chorobą wieńcową (wynik w skali Gensiniego ≥ 1) z pacjentami, którzy nie cierpieli na tę chorobę (n = 29, wynik skali Gensiniego: 0), okazało się, że ich średnie stężenia testosteronu w surowicy były niższe (p = 0,043). Nie wykryto korelacji pomiędzy stę-żeniami testosteronu a stężeniami cholesterolu -lipoproteiny wysokiej gęstości oraz trójglicerydów. Wystąpiła korelacja pomiędzy stężeniami testosteronu w surowicy oraz całkowitymi stężeniami cholesterolu (p = 0,008), cholesterolu -lipoproteiny niskiej gęstości (p = 0,019) oraz wskaźnikiem BMI (p = 0,001). Wnioski: Średnie stężenia testosteronu w surowicy były niż-sze u pacjentów z chorobą wieńcową. Nie udało się udokumentować ich związku z nasileniem choroby za pomocą skali Gensiniego. Słowa kluczowe: choroba wieńcowa, testosteron, skala Gensiniego. Kardiochirurgia i Torakochirurgia Polska 2013; 10 (3) 211 CARDIAC SURGERY AbstractBackground: The relation between coronary artery disease (CAD) and the levels of serum androgen has been revealed in various population studies. The Gensini coronary scoring system is used to evaluate the degree of coronary stenosis, taking into account its location and producing a numerical score. The aim of the study was to explore the association between serum testosterone levels and both the presence and severity of coronary artery disease indicated by the Gensini score in middle-aged men. Material and methods: Between October 2011 and April 2012, 124 middle-aged (40-59) male patients with known or suspected coronary artery disease were included in the study. Coronary angiography was performed in all patients, and their Gensini scores were calculated. Total serum testosterone levels were also measured. Results: The mean Gensini score of the patients was 44.11 ±39.08. The mean plasma testosterone level was 3.51 ±1.39 ng/ml. There was no correlation between the severity of coronary artery disease and the serum testosterone levels (r = -0.161, p > 0.05). When the patients with coronary ar...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cardiac surgery The association between serum testosterone levels and coronary artery disease in middle-aged men

Durukan¹,

Gürbüz²,

Tanalp³

et al. 2013

kitp

View full text Add to dashboard Cite

show abstract

“…In addition to the several studies that have demonstrated an association between low testosterone levels and coronary artery disease (46,53,87,164), other evidence demonstrated that low testosterone is not only associated with coronary artery disease, but also with its severity (46,111,145,164). Svartberg et al (182) demonstrated an inverse association between total testosterone levels and intima-media thickness after adjusting for smoking, physical activity, blood pressure, and lipid levels, in a population-based and cross-sectional study of 1,482 men.…”

Section: Is Testosterone a Good Or Bad Guy For Cardiovascular Systemsmentioning

confidence: 99%

Reactive oxygen species: players in the cardiovascular effects of testosterone

Tostes

Carneiro

Carvalho

et al. 2016

American Journal of Physiology-Regulatory, Integrative and Comp

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Tostes RC, Carneiro FS, Carvalho MH, Reckelhoff JF. Reactive oxygen species: players in the cardiovascular effects of testosterone. Am J Physiol Regul Integr Comp Physiol 310: R1-R14, 2016. First published November 4, 2015 doi:10.1152/ajpregu.00392.2014.-Androgens are essential for the development and maintenance of male reproductive tissues and sexual function and for overall health and well being. Testosterone, the predominant and most important androgen, not only affects the male reproductive system, but also influences the activity of many other organs. In the cardiovascular system, the actions of testosterone are still controversial, its effects ranging from protective to deleterious. While early studies showed that testosterone replacement therapy exerted beneficial effects on cardiovascular disease, some recent safety studies point to a positive association between endogenous and supraphysiological levels of androgens/testosterone and cardiovascular disease risk. Among the possible mechanisms involved in the actions of testosterone on the cardiovascular system, indirect actions (changes in the lipid profile, insulin sensitivity, and hemostatic mechanisms, modulation of the sympathetic nervous system and renin-angiotensin-aldosterone system), as well as direct actions (modulatory effects on proinflammatory enzymes, on the generation of reactive oxygen species, nitric oxide bioavailability, and on vasoconstrictor signaling pathways) have been reported. This mini-review focuses on evidence indicating that testosterone has prooxidative actions that may contribute to its deleterious actions in the cardiovascular system. The controversial effects of testosterone on ROS generation and oxidant status, both prooxidant and antioxidant, in the cardiovascular system and in cells and tissues of other systems are reviewed. cardiovascular; prooxidant; antioxidant TESTOSTERONE 1 IS THE PREDOMINANT and most important androgen, playing a major role in the development of male reproductive tissues (130,135). "Androgen" is a broad term for any natural or synthetic compound that primarily influences the growth and development of the male reproductive system, including the activity of the accessory male sex organs and development of male secondary sex characteristics (21, 135). Androgens are also essential for health and well being, and their beneficial and stimulant effects have been known for a long time, since the seminal studies from Brown-Séquard in the nineteenth century 2 (22, 135): "ь ь ь in the seminal fluid, as secreted by the testicles, a substance or several substances exist which, entering the blood by resorption, have a most essential use in giving strength to the nervous system and to other parts ь ь ь ."Other androgens include androstenedione, 5␣-dihydrotestosterone (DHT), which is produced from testosterone by the enzyme 5␣-reductase, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEA-S), and synthetic androgens in their many steroid ester variations (e.g., testosterone cypionate, decanoate, undecanoate, enant...

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“…[6][7] There are studies that have shown the relationship between low endogenous testosterone levels and risk factors of CAD which include haemostatic risk factors, obesity, hypertension, dyslipidaemia, diabetes mellitus and metabolic syndrome. [8][9] Among the new or emerging risk factors, particularly inflammatory markers might identify the high risk group and might benefit from more aggressive risk reduction.…”

Section: Novel Risk Factors For Coronary Artery Diseasementioning

confidence: 99%

“…5 Among the novel risk factors of CAD, sex hormones are known to have cardiovascular effects. Epidemiological studies have identified an inverse association between testosterone and CAD in men, 6 and reduced testosterone concentration has a link to premature CAD. …”

Section: Introductionmentioning

confidence: 99%

Novel risk factors for coronary artery disease – role of testosterone and high-sensitivity CRP in Sri Lankan males

Wickramatilake

2017

J of Cey Coll of Phy

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Coronary artery disease (CAD) is multi-factorial in origin and develops as a result of both genetic and environmental factors. Traditional risk factors (generally smoking, hypertension, raised lipids, and diabetes mellitus) do not explain all of the risk for coronary disease events. There remain several other factors that contribute to the overall risk. Various new or emerging risk factors have been studied to improve global risk assessment for CAD. Inflammation indicated by markers as Creactive protein and low androgen (testosterone) status in males are among the emerging risk factors. In the local setting, the association of testosterone with CAD has not been explored, although this relationship has been well-studied in the Western population. Therefore we investigated, whether serum levels of total testosterone (TT) and high sensitivity C-reactive protein (hs-CRP) differ in men with CAD from those without CAD and to evaluate the relationship of serum TT and hs-CRP with the severity of CAD.Three hundred and nine males (103 patients with ST-elevation myocardial infarction (STEMI), 103 patients with angiographically-proven CAD, 103 controls without having a history of CAD) were studied. Serum TT, hs-CRP, lipids, cardiac troponin I (cTnI) and plasma glucose were estimated. Three angiogram-based severity scores were used in the severity assessment of angiographically-proven CAD. In STEMI patients, clinical risk scores and modified Selvester ECG QRS score were used in assessing the severity of myocardial infarction.We showed that low levels of total testosterone, high levels of hs-CRP, abnormal lipid profile and raised plasma glucose contribute to an atherogenic milieu. Low levels of total testosterone and high level of hs-CRP can be perceived as risk factors of coronary artery disease.

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Low testosterone level in middle-aged male patients with coronary artery disease

Cited by 57 publications

References 18 publications

Cardiac surgery The association between serum testosterone levels and coronary artery disease in middle-aged men

Cardiac surgery The association between serum testosterone levels and coronary artery disease in middle-aged men

Reactive oxygen species: players in the cardiovascular effects of testosterone

Novel risk factors for coronary artery disease – role of testosterone and high-sensitivity CRP in Sri Lankan males

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