Low thigh muscle mass is associated with coronary artery stenosis among HIV-infected and HIV-uninfected men: The Multicenter AIDS Cohort Study (MACS)

Tibuakuu, Martin; Zhao, Di; Saxena, Ankita; Brown, Todd T.; Jacobson, Lisa P.; Palella, Frank J.; Witt, Mallory D.; Koletar, Susan L.; Margolick, Joseph B.; Güallar, Eliseo; Korada, Sai Krishna C.; Budoff, Matthew J.; Post, Wendy S.; Michos, Erin D.

doi:10.1016/j.jcct.2018.01.007

Cited by 6 publications

(6 citation statements)

References 46 publications

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“…The results of the present study should be interpreted by considering the minor differences between the included and excluded populations. Fourth, the sample of 475 patients was relatively large compared to that in previous studies of sarcopenia using CT in research on cardiovascular disease [11,12,13,14,15,16,17,28]. However, this sample size was not large enough to draw solid conclusions.…”

Section: Discussionmentioning

confidence: 96%

“…Previous studies reported that sarcopenia assessed with various methods was closely associated with subclinical features of CAD, such as coronary artery calcification [8,27] and subclinical coronary artery stenosis [28]. However, the prognostic significance of sarcopenia in CAD based on real-world data has not been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported that sarcopenia determined using various methods is closely associated with a higher prevalence of cardiometabolic risk factors and established ASCVD [8,9,28]. The presence of sarcopenia is also a contributing factor in poor cardiopulmonary function in patients with CAD [10].…”

Section: Discussionmentioning

confidence: 99%

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Prognostic Impact of Low Skeletal Muscle Mass on Major Adverse Cardiovascular Events in Coronary Artery Disease: A Propensity Score-Matched Analysis of a Single Center All-Comer Cohort

Kang

Park

Choi

et al. 2019

JCM

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The impact of sarcopenia on atherosclerotic cardiovascular disease remains unclear. We aimed to investigate the prognostic impact of sarcopenia on coronary artery disease (CAD). A total of 475 patients with CAD who underwent successful percutaneous coronary intervention (PCI) and computed tomography (CT) were enrolled. The cross-sectional area of skeletal muscle at the first lumbar (L1) vertebral level was measured, and sex-specific cut-off values of L1 skeletal muscle index (L1 SMI; male <31.00 cm2/m2, female <25.00 cm2/m2) were obtained. The primary outcome was 3-year all-cause mortality and the secondary outcome was 3-year major adverse cardiovascular events (MACEs). Low L1 SMI was present in 141 (29.7%) of 475 patients. The incidence of all-cause mortality (23.7% vs. 5.9%, p < 0.001) and MACEs (39.6% vs. 11.8%, p < 0.001) was significantly higher in patients with low L1 SMI than in those with high L1 SMI. In multivariate analysis, low L1 SMI was an independent predictor of higher risk of all-cause mortality (hazard ratio (HR): 4.07; 95% confidence interval (CI): 1.95–8.45; p < 0.001) and MACEs (HR: 3.76; 95% CI: 2.27–6.23; p < 0.001). These findings remained consistent after propensity score-matched analysis with 91 patient pairs (C-statistic = 0.848). CT-diagnosed low skeletal muscle mass is a powerful predictor of adverse outcomes in patients with CAD undergoing PCI.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Prognostic Impact of Low Skeletal Muscle Mass on Major Adverse Cardiovascular Events in Coronary Artery Disease: A Propensity Score-Matched Analysis of a Single Center All-Comer Cohort

Kang

Park

Choi

et al. 2019

JCM

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“…Loss of lean mass quantity and quality occurs with HIV infection, ART, and FHT [106,107] . Lean mass loss has been associated with mortality in the general population [108] , and lower lean mass is associated with greater subclinical obstructive coronary stenosis in men with and without HIV [109] . Thus, changes in lean and fat mass with HIV infection, ART, and FHT may converge to promote additive or synergistic immuno-metabolic and cardiometabolic disturbances in PLWH.…”

Section: Immuno-metabolic Effects Of Hivmentioning

confidence: 99%

Optimizing HIV prevention and care for transgender adults

Lake

Clark

2019

Aids

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“…Cumulative clinical evidence supports the relations between age-related loss of muscle mass and function, called sarcopenia, and insulin resistance, mitochondrial dysfunction, and systemic inflammation [ 6 , 7 ]. Specifically, decreased lower extremity appendicular skeletal muscle (LASM) is related to high risk for obstructive coronary heart disease [ 8 ]. One study reported that low LASM mass is associated with an increased ratio of hospitalization in patients with type 2 diabetes [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Association between Lower-to-Upper Ratio of Appendicular Skeletal Muscle and Metabolic Syndrome

Moon

Lee

Chung

2022

JCM

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(1) Background: Metabolic syndrome (MetS) is a cluster-based disorder comprising several pre-disease or pre-clinical statuses for diabetes, hypertension, dyslipidemia, cardiovascular risk, and mortality. Appendicular skeletal muscle (ASM), or lean mass, is considered the main site of insulin-mediated glucose utilization. Therefore, we aimed to reveal the association between lower appendicular skeletal muscle mass to upper appendicular skeletal muscle mass ratio (LUR) and risk for MetS. (2) Methods: We analyzed the 2008–2011 Korean National Health Examination and Nutrition Survey (KNHANES) data. Quintiles of lower ASM to upper ASM ratio (LUR) were categorized as follows: Q1: ≤2.65, Q2: 2.66–2.80, Q3: 2.81–2.94, Q4: 2.95–3.11, and Q5: ≥3.12 in men and Q1: ≤3.00, Q2: 3.01–3.18, Q3: 3.19–3.36, Q4: 3.37–3.60, and Q5: ≥3.61 in women. Multivariate logistic regression models were used after setting MetS and the LUR quintiles as the independent and dependent variables and adjusting for covariates. (3) Result: In men, MetS in accordance with the LUR quintiles exhibits a reverse J-curve. All groups from Q2 to Q5 had a lower odds ratio (OR) (95% CI) for MetS compared to the Q1 group. The lowest OR (95% CI) of 0.85 (0.80–0.91) was observed in Q4. However, in women, the figure shows a sine curve. Compared to the Q1 group, the Q2 and Q3 groups had a higher OR, while the Q4 and Q5 groups presented a lower OR. Among them, the OR (95% CI) in the Q4 group was lowest, at 0.83 (0.76–0.91). (4) Conclusions: While total appendicular skeletal muscle mass is important to prevent MetS, it is necessary to maintain an optimal ratio of muscle mass between the upper and lower appendicular skeletal muscle mass.

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Low thigh muscle mass is associated with coronary artery stenosis among HIV-infected and HIV-uninfected men: The Multicenter AIDS Cohort Study (MACS)

Cited by 6 publications

References 46 publications

Prognostic Impact of Low Skeletal Muscle Mass on Major Adverse Cardiovascular Events in Coronary Artery Disease: A Propensity Score-Matched Analysis of a Single Center All-Comer Cohort

Prognostic Impact of Low Skeletal Muscle Mass on Major Adverse Cardiovascular Events in Coronary Artery Disease: A Propensity Score-Matched Analysis of a Single Center All-Comer Cohort

Optimizing HIV prevention and care for transgender adults

Association between Lower-to-Upper Ratio of Appendicular Skeletal Muscle and Metabolic Syndrome

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