Low triglyceride as a marker for increased risk of cardiovascular diseases in patients with long‐term type 2 diabetes: A cross‐sectional survey in China

Ren, Yudong; Ren, Qian; Lu, Juming; X, Guo; Huo, Xiaoxu; Ji, Linong; Yang, Xilin

doi:10.1002/dmrr.2960

Cited by 13 publications

(9 citation statements)

References 32 publications

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“…Secondly, the subgroup analyses on the impact of TG on CVD showed prominence among T2DM individuals with a mean age < 65 years. It is consistent with a recent cross-sectional study which found higher TG level was associated with an increased risk of CVD among the patients with short duration of diabetes, whereas, a lower TG level was associated with an increased risk of CVD in patients with longer duration of diabetes, and this association was mainly driven by CHD [34]. Older age tends to have a longer duration of diabetes in general.…”

Section: Discussionsupporting

confidence: 91%

Serum triglycerides as a risk factor for cardiovascular diseases in type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies

Kong

Zafar

et al. 2019

Cardiovasc Diabetol

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Objective: The importance of triglycerides (TG) level as a risk factor for cardiovascular diseases (CVD) has been extensively investigated in the general population; however, their relationship in patients with type 2 diabetes mellitus (T2DM) is uncertain. We aimed to assess the association of TG with CVD in T2DM individuals. Research design and methods: We searched bibliographic databases for studies published until June 2018, reporting on the relationship between TG and CVD in T2DM people. A random-effects model with inverse variance weighting was used to compute pooled estimates of the most fully adjusted risk ratios (RR) and corresponding 95% confidence intervals (CI) according to TG categories, unit TG, and logarithm (log) of TG for CVD. Results: A total of 31 studies were included, involving 132,044 T2DM patients with 10,733 incident cardiovascular events. The pooled RR (95% CI) of CVD for an increase in baseline TG, log TG by 1-mmol/l and categorized in the highest vs. the lowest TG in T2DM were 1.06 (1.02, 1.09), 1.30 (1.18, 1.42) and 1.30 (1.16, 1.46), corresponding to a CVD risk increase of 6%, 30% and 30%, respectively. The pooled RR (95% CI) of CVD for per 1-mmol/L TG increment in eight studies and TG categories in three studies were 1.03 (0.98, 1.08) and 1.39 (0.92, 2.1) in T2DM patients adjusted for other lipids parameter, respectively. Conclusions: In T2DM patients, an elevated triglyceride level cannot serve as an independent marker for an increased risk of cardiovascular events, but still, the higher serum TG levels tend to be associated with increased risks of CVD.

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Section: Discussionsupporting

confidence: 91%

Serum triglycerides as a risk factor for cardiovascular diseases in type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies

Kong

Zafar

et al. 2019

Cardiovasc Diabetol

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“…It is also well known that statins also have a triglyceride-lowering effect [ 83 ]. In a cross-sectional study of 223,612 patients with T2DM in China, researchers found that although lower triglyceride was associated with reduced CVD risk in the short-term, it was associated with increased risk in the long-term [ 84 ]. This paradox could mean that low triglyceride is not necessarily associated with good clinical outcomes in all people with T2DM and that there are subgroup associations with CVD in patients with different durations of T2DM.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017

Einarson

Acs²,

Ludwig³

et al. 2018

Cardiovasc Diabetol

1,587

1,079

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BackgroundCardiovascular disease (CVD) is a common comorbidity in type 2 diabetes (T2DM). CVD’s prevalence has been growing over time.PurposeTo estimate the current prevalence of CVD among adults with T2DM by reviewing literature published within the last 10 years (2007–March 2017).MethodsWe searched Medline, Embase, and proceedings of major scientific meetings for original research documenting the prevalence of CVD in T2DM. CVD included stroke, myocardial infarction, angina pectoris, heart failure, ischemic heart disease, cardiovascular disease, coronary heart disease, atherosclerosis, and cardiovascular death. No restrictions were placed on country of origin or publication language. Two reviewers independently searched for articles and extracted data, adjudicating results through consensus. Data were summarized descriptively. Risk of bias was examined by applying the STROBE checklist.ResultsWe analyzed data from 57 articles with 4,549,481 persons having T2DM. Europe produced the most articles (46%), followed by the Western Pacific/China (21%), and North America (13%). Overall in 4,549,481 persons with T2DM, 52.0% were male, 47.0% were obese, aged 63.6 ± 6.9 years old, with T2DM duration of 10.4 ± 3.7 years. CVD affected 32.2% overall (53 studies, N = 4,289,140); 29.1% had atherosclerosis (4 studies, N = 1153), 21.2% had coronary heart disease (42 articles, N = 3,833,200), 14.9% heart failure (14 studies, N = 601,154), 14.6% angina (4 studies, N = 354,743), 10.0% myocardial infarction (13 studies, N = 3,518,833) and 7.6% stroke (39 studies, N = 3,901,505). CVD was the cause of death in 9.9% of T2DM patients (representing 50.3% of all deaths). Risk of bias was low; 80 ± 12% of STROBE checklist items were adequately addressed.ConclusionsGlobally, overall CVD affects approximately 32.2% of all persons with T2DM. CVD is a major cause of mortality among people with T2DM, accounting for approximately half of all deaths over the study period. Coronary artery disease and stroke were the major contributors.

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“…In patients with diabetes, hypertriglyceridemia plus low HDL-C levels were associated with a 2.13-fold greater HR and 95% CI (1.06 to 4.29) for stroke (P=0.060) when compared with those in individuals with P<0.001). 30 Moreover, hypertriglyceridemia is a risk factor for stroke irrespective of age. In a cross-sectional study on acute ischemic stroke (AIS) in children, hypertriglyceridemia was more common in children with arterial ischemic stroke than in those without stroke.…”

Section: Effects Of Triglycerides On the Risk Of Ischemic Strokementioning

confidence: 99%

Hypertriglyceridemia: A Neglected Risk Factor for Ischemic Stroke?

Liang

Zhang

et al. 2022

J Stroke

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Hypertriglyceridemia is caused by defects in triglyceride metabolism and generally manifests as abnormally high plasma triglyceride levels. Although the role of hypertriglyceridemia may not draw as much attention as that of plasma cholesterol in stroke, plasma triglycerides, especially nonfasting triglycerides, are thought to be correlated with the risk of ischemic stroke. Hypertriglyceridemia may increase the risk of ischemic stroke by promoting atherosclerosis and thrombosis and increasing blood viscosity. Moreover, hypertriglyceridemia may have some protective effects in patients who have already suffered a stroke via unclear mechanisms. Therefore, further studies are needed to elucidate the role of hypertriglyceridemia in the development and prognosis of ischemic stroke.

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Low triglyceride as a marker for increased risk of cardiovascular diseases in patients with long‐term type 2 diabetes: A cross‐sectional survey in China

Abstract: Whereas a high triglyceride level was associated with increased risk of CVD in short-term T2DM, low triglyceride was associated with increased CVD risk in long-term T2DM. Low triglyceride may be a marker of CVD risk in Chinese patients with long-term T2DM.

Cited by 13 publications

References 32 publications

Serum triglycerides as a risk factor for cardiovascular diseases in type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies

Serum triglycerides as a risk factor for cardiovascular diseases in type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies

Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017

Hypertriglyceridemia: A Neglected Risk Factor for Ischemic Stroke?

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