Low Turnover Bone Disease in Early CKD Stages

Frontiers in Bone Metabolism and Disorder in Chronic Kidney Disease

“…In recent years, research has suggested that other factors and signal pathways seem to be involved in the pathogenesis of renal osteodystrophy. The anabolic Wnt pathway in bone is disturbed at the early stages of CKD with an increased expression of the Wnt inhibitor sclerostin [26,27]. Plasma levels of sclerostin are increased in CKD patients.…”