Low vitamin D is associated with hypertension in paediatric obesity

Kao, Kung‐Ting; Abidi, Nobia Fatima; Ranasinha, Sanjeeva; Brown, Justin; Rodda, Christine; McCallum, Zoë; Zacharin, Margaret; Simm, Peter; Magnussen, Costan G.; Sabin, Matthew A.

doi:10.1111/jpc.12935

Cited by 37 publications

(38 citation statements)

References 42 publications

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“…Severe vitamin D deficiency leads to rickets with negative impact on height but the impact of moderately lowered vitamin D level in adolescents on final height remains unclear [21]. The negative relation between 25(OH)D status and BMI is consistent with results of studies by Turer [22], Kao [17], and Płudowski [16]. According to Polish guidelines, both short stature and obesity are conditions associated with risk for vitamin D deficiency and indications for assessment of vitamin D status [5].…”

Section: Discussionsupporting

confidence: 74%

“…On the other hand, in a study by Kao [6] lower vitamin D concentrations were related to both higher systolic and diastolic blood pressure in overweight and obese adolescents. Noteworthy, in contrast to our study, Kao [17] did not use ABPM, which more precisely reflects blood pressure compared to office measurements.…”

Section: Discussioncontrasting

confidence: 61%

“…Also these authors [16] did not find relation between vitamin D supply and carotid intima media thickness and left ventricular mass. Kao [17] found that vitamin D status is inversely related to systolic and diastolic blood pressure in overweight and obese adolescents.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D in children with primary hypertension

Skrzypczyk

Ofiara

Szyszka

et al. 2018

Arterial Hypertension

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Introduction:Recent evidence suggests that vitamin D plays a role in pathogenesis of arterial hypertension. The aim was to assess vitamin D in children and adolescents with arterial hypertension. Material and methods: In 49 children (14.29 ± 3.17 years) with arterial hypertension we evaluated vitamin D status (according to Polish 2018 Guidelines), serum calcium, phosphorus, parathormone, alkaline phosphatase, office blood pressure, ABPM (including ambulatory arterial stiffness index [AASI]), BMI, GFR, uric acid, lipids and albuminuria. None of the children were supplemented with vitamin D. Results: Mean vitamin D concentration was 19.74 ± 9.68 ng/mL. Vitamin D severe deficiency (0-10 ng/mL) was found in 5 (10.2%), deficiency (> 10-20 ng/mL) in 29 (49.0%), suboptimal concentration (> 20-30 ng/mL) in 17 (34.7%), optimal concentration (> 30 to 50 ng/mL) in 1 (2.0%), and high concentration (> 50 to 100 ng/mL) in 2 (4.1%) children. Vitamin D was higher in spring-summer vs. autumn-winter (21.79 ± 10.19 vs. 15.53 ± 7.08 ng/mL, p = 0.03). Vitamin D correlated with height Z-score (r = 0.39, p < 0.01), BMI Z-score (r = -0.34, p = 0.02), uric acid (r = -0.31, p = 0.04), triglycerides (r = -0.37, p = 0.01), but not with office blood pressure and ABPM parameters except for heart rate (r = -0.38, p < 0.01). In 24 children treated with antihypertensive medications vitamin D correlated with AASI (r = 0.50, p = 0.04). Conclusions:1. Inadequate vitamin D supply is ubiquitous in children with arterial hypertension. 2. Vitamin D deficiency should be suspected especially in autumn-winter period and among obese and short children. 3. The relation between vitamin D status and ambulatory arterial stiffness index suggests negative influence of vitamin D on arterial wall but requires further investigations.

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Section: Discussionsupporting

confidence: 74%

Section: Discussioncontrasting

confidence: 61%

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Vitamin D in children with primary hypertension

Skrzypczyk

Ofiara

Szyszka

et al. 2018

Arterial Hypertension

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“…50 Se ha reportado en adolescentes una asociación inversa entre las concentraciones de 25(OH)D y presión sistólica. 51 Además, hay estudios en los últimos años que muestran una posible asociación en algunas formas de cáncer, tanto en adultos como en niños. 2 Futuros estudios podrán demostrar si el manejo de la deficiencia previene alguna de estas condiciones.…”

Section: Asmaunclassified

Deficiencia de vitamina D en la práctica clínica pediátrica

2018

Arch Argent Pediatr

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“…50 A reverse association has been reported between 25(OH)D levels and systolic blood pressure in adolescents. 51 There are other studies that have been conducted in recent years and showed a potential association with some forms of cancer, both in adults and children.…”

Section: Asthma and Vddmentioning

confidence: 99%

Vitamin D deficiency in pediatric clinical practice

Cediel¹,

Pacheco-Acosta

CastiUo-Durdn

2018

Arch Argent Pediatr

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Vitamin D research suggests it has a role in disorders other than bone metabolism. Objective: To update the information on vitamin D deficiency (VDD) in pediatric clinical disorders. Methods: Search in virtual libraries, giving priority to clinical and longitudinal studies and meta-analyses on VDD in the pediatric age group published in the past 20 years. The terms "vitamin D deficiency", "children and adolescents" (both in Spanish and English) were used as search descriptors. Results:In the pediatric population, VDD is associated with different clinical diseases, such as bone alterations, insulin resistance, metabolic syndrome, respiratory tract infections, asthma, and autoimmune diseases. Besides, it is associated with prematurity, obesity, malabsorption, use of anticonvulsant agents, and lifestyle characteristics, such as clothing, extreme latitudes, low consumption, and little sun exposure. Conclusions: According to the evidence, VDD is highly prevalent in several disorders and diseases in the pediatric age group. The recommendation is to prevent VDD in risk conditions and to maintain 25(OH)D serum levels > 75 nmol/L.

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Low vitamin D is associated with hypertension in paediatric obesity

Abstract: Overweight and obese youth attending specialist obesity services have a high prevalence of vitamin D deficiency. In this population, lower levels of vitamin D were seen in those with greater adiposity, and independent of this, in those who had higher blood pressure.

Cited by 37 publications

References 42 publications

Vitamin D in children with primary hypertension

Vitamin D in children with primary hypertension

Deficiencia de vitamina D en la práctica clínica pediátrica

Vitamin D deficiency in pediatric clinical practice

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