Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population

Cheng, Hui Mei; Kim, Sunmi; Park, Gyeong-Hun; Chang, Sung Eun; Bang, Si Ra; Won, Chong Hyun; Lee, Mi Woo; Choi, Jee Ho; Moon, Kee Chan

doi:10.1016/j.jaci.2013.10.055

Cited by 125 publications

(101 citation statements)

References 47 publications

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“…Epidemiological studies have linked vitamin D deficiency to respiratory diseases, including lung cancer, chronic obstructive pulmonary disease, and asthma (16,26,43). However, while there is evidence that higher vitamin D levels may reduce the risk of asthma exacerbations, there is inconclusive evidence that vitamin D deficiency has the capacity to cause asthma (5,13,34).Asthma is an inflammatory disorder affecting the conducting airways (22). Allergic asthma is characterized by T helper (Th) 2 type inflammation, and persistent airway inflammation drives structural alterations in the lung (32).…”

mentioning

confidence: 99%

Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease

Foong

Bosco

Troy

et al. 2016

American Journal of Physiology-Lung Cellular and Molecular Phys

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Vitamin D deficiency is associated with asthma risk. Vitamin D deficiency may enhance the inflammatory response, and we have previously shown that airway remodeling and airway hyperresponsiveness is increased in vitamin D-deficient mice. In this study, we hypothesize that vitamin D deficiency would exacerbate house dust mite (HDM)-induced inflammation and alterations in lung structure and function. A BALB/c mouse model of vitamin D deficiency was established by dietary manipulation. Responsiveness to methacholine, airway smooth muscle (ASM) mass, mucus cell metaplasia, lung and airway inflammation, and cytokines in bronchoalveolar lavage (BAL) fluid were assessed. Gene expression patterns in mouse lung samples were profiled by RNA-Seq. HDM exposure increased inflammation and inflammatory cytokines in BAL, baseline airway resistance, tissue elastance, and ASM mass. Vitamin D deficiency enhanced the HDM-induced influx of lymphocytes into BAL, ameliorated the HDM-induced increase in ASM mass, and protected against the HDM-induced increase in baseline airway resistance. RNA-Seq identified nine genes that were differentially regulated by vitamin D deficiency in the lungs of HDM-treated mice. Immunohistochemical staining confirmed that protein expression of midline 1 (MID1) and adrenomedullin was differentially regulated such that they promoted inflammation, while hypoxia-inducible lipid dropletassociated, which is associated with ASM remodeling, was downregulated. Protein expression studies in human bronchial epithelial cells also showed that addition of vitamin D decreased MID1 expression. Differential regulation of these genes by vitamin D deficiency could determine lung inflammation and pathophysiology and suggest that the effect of vitamin D deficiency on HDM-induced allergic airways disease is complex. airway remodeling; airway hyperresponsiveness; mouse model; RNASeq; house dust mite VITAMIN D DEFICIENCY IS PREVALENT all over the world and is a public health concern. Epidemiological studies have linked vitamin D deficiency to respiratory diseases, including lung cancer, chronic obstructive pulmonary disease, and asthma (16,26,43). However, while there is evidence that higher vitamin D levels may reduce the risk of asthma exacerbations, there is inconclusive evidence that vitamin D deficiency has the capacity to cause asthma (5,13,34).Asthma is an inflammatory disorder affecting the conducting airways (22). Allergic asthma is characterized by T helper (Th) 2 type inflammation, and persistent airway inflammation drives structural alterations in the lung (32). These structural changes, termed airway remodeling, lead to reversible airflow obstruction, deficits in lung function, and airway hyperresponsiveness (AHR) (32). These functional deficits are ultimately linked to asthma-related morbidity. Vitamin D has important immunomodulatory properties, as evidenced by the widespread expression of the vitamin D receptor on immune cells, including activated T and B cells, macrophages, and dendritic cells (18). Studies hav...

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confidence: 99%

Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease

Foong

Bosco

Troy

et al. 2016

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…Her 25 nM azalma, riski, erkeklerde 1.84 kat artırırken, kadınlarda azaltmıştır. [79,80] Meyve ve meyve suyu tüketimi AR riskini azaltırken; koruyucu, renklendirici, suni tatlandırıcı içeren veya boza gibi fermente içecekler riski artırmaktadır. [6][7][8]12,48,75] Antioksidan yiyecekler Domates, çikolata ve kakao gibi antioksidan yiyeceklerin sık tüketimi riski azaltmaktadır.…”

Section: Akdeniz Diyetiunclassified

Variable prevalence of allergic rhinitis and risk factors affecting the prevalence

Özdemir

Elmas²

2016

Kulak Burun Bogaz Ihtis Derg

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ÖZAlerjik rinit burunda akıntı, hapşırık, kaşıntı ve tıkanıklık, sıklıkla konjonktival enjeksiyon ve gözde kaşınmayla karakterize olan burun mukozasının kronik enflamasyonu olarak tanımlanmaktadır. Çocukluk çağı alerjik rinit prevalansı dünya çapında hızlı bir artış göstermektedir. Ancak bölgeler arasında bariz farklar vardır, bu da alerjik rinitin gelişiminde değişen genetik ve çevresel etkenlere işaret etmektedir. Bölgesel bu fark, genetik yatkınlık yanında çevresel ve davranışsal faktörlerin hızlı değişimiyle meydana gelen 'Batı tarzı diyet' ve 'Batılı yaşam tarzı' ile esas olarak ilişkili bulunmuştur. Alerjik rinit gelişimine yol açan bazı ana ve potansiyel risk faktörleri halen net olarak bilinmemektedir. Bu derlemede, çoğu iyi bilinen ve bazı yeni ortaya çıkmış risk faktörleri son literatür verileri ışığında tartışılacaktır.Anahtar Sözcükler: Allerjik rinit; prevalans; risk faktörü. ABSTRACTAllergic rhinitis is described as a chronic inflammation of the nasal mucosa causing rhinorrhea, sneezing, nasal congestion and itching, often characterized with conjunctival injection and ocular itching. The prevalence of pediatric allergic rhinitis has recently shown a sharp increase throughout the world. However, there are significant differences among the regions, thus indicating to the influence of varying genetic and environmental factors upon the development of allergic rhinitis. This regional difference is mainly related to the 'western diet' and 'western lifestyle', with its swift changes in environmental and behavioral factors, besides a genetic predisposition. Some main and potential risk factors contributing to the development of allergic rhinitis are still unclear. In this review, we discuss mostly well known and some emerging new risk factors in the light of recent literature.

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“…18 Participants who commit to moderate physical activity at least 5 days per week for more than 30 minutes each day and/or strenuous physical activity for more than 20 minutes per session at least 3 days per week were classified as the regular exercise group. 19 Residency was categorized into urban and rural areas according to the official address of the subjects. The category of 'low income' corresponded to the lowest quartile of annual household income.…”

Section: Demographic Characteristicsmentioning

confidence: 99%

“…The following question was used to assess physician-diagnosed AR for each participant: "Have you been diagnosed with AR by a doctor?" 19 Physician-diagnosed depression was also determined by using similar questions: "Have you been diagnosed with depression by a doctor?" Stress levels assessed by the questionnaire were categorized into low (none or small amount) or high (some or extreme).…”

Section: Assessment Of Variablesmentioning

confidence: 99%

Relationship Between Allergic Rhinitis and Mental Health in the General Korean Adult Population

Kim

2016

Allergy Asthma Immunol Res

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.Purpose: This study was conducted to evaluate the association between AR and mental health status in the general Korean adult population and to investigate the relative burden of AR on mental health using the Allergic Rhinitis and Its Impact on Asthma (ARIA) classification. Methods: A cross-sectional study was performed by using data from 11,154 individuals, 19 years old or older in the Korean National Health and Nutrition Examination Survey 2011-2012. Univariate analysis was conducted in the healthy AR groups with weighted prevalence of demographic characteristics, socioeconomic status, and comorbid diseases. Subanalysis that classified AR severity according to the ARIA classification was carried out to evaluate the relationship of AR severity with mental health. The odds ratios (ORs) for each component representing mental health status were estimated by multiple logistic regression analysis with confounder adjustment. Results: Univariate analysis with the chi-square test after adjustment for age, sex, body mass index, smoking status, alcohol use status, and exercise status, components representing mental health status showed a linear relationship with the severity of AR according to the ARIA classification. Stress, depressive mood, suicidal thoughts, and psychological consultation factors were correlated with AR after adjustment for demographic characteristics and socioeconomic status. Even after adjustment for comorbid allergic diseases, the correlation remained significant with stress, depressive mood, and psychological consultation factors ( Patients with AR appear to be at higher risk of mental disorders in the general Korean adult population. Moreover, persistent or severe AR was correlated with poor mental health. Therefore, better control of AR may be conducive to better mental health, and more attention should be paid to the psychological status of AR patients.

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Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population

Cited by 125 publications

References 47 publications

Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease

Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease

Variable prevalence of allergic rhinitis and risk factors affecting the prevalence

Relationship Between Allergic Rhinitis and Mental Health in the General Korean Adult Population

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