Lower confidence limits for critical systematic errors

Gernand, Wojciech; Dumnicka, Paulina; Kuśnierz-Cabała, Beata; Kapusta, Maria Małgorzata; Solnica, Bogdan

doi:10.1016/j.clinbiochem.2007.07.020

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…This uncertainty has a potential impact on the selection of QC rules out of the Westgard rules. This issue is briefly touched by Gernand and coworkers with respect to

Δ_{L}^{S E}

43,44 . Besides, Tsiamyrtzis et al point to the uncertainty of the bias and imprecision from a Bayesian point of view 45 …”

Section: Discussionmentioning

confidence: 99%

Selection of within‐run quality control rules for laboratory biomarkers

Laubender

Geistanger

2021

Statistics in Medicine

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In order to release correct biomarker results of a laboratory test, it is a regulatory requirement to apply quality control standards for controlling analytical errors. Releasing an incorrect test result might lead to wrong diagnosis or treatment of a patient in medical decision‐making. In laboratory medicine, one of the means to control analytical errors is statistical process control procedures proposed by James O. Westgard and his coworkers nowadays known as “Westgard rules.” To judge their performance for discriminating in‐control from out‐of‐control processes, power curves are used. In this article, we describe functions for the power curves of the within‐run Westgard rules. Based on these power curves, we use a benchmark approach for selecting a quality control procedure out of the set of Westgard rules. It is shown that two graphical procedures proposed by Westgard and his coworkers can be reduced to this benchmark approach. Besides, a commonly used measure in laboratory medicine for describing out‐of‐control processes is critically examined revealing the threat of selecting too optimistic quality control rules.

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“…This uncertainty has a potential impact on the selection of QC rules out of the Westgard rules. This issue is briefly touched by Gernand and coworkers with respect to