Purpose of the study: to improving the effectiveness of rehabilitation of patients with mandibular defects of various etiologies based on the development and application of new medical technologies using shape memory materials.Material and methods. Using medical materials developed at the Research Institute of Medical Materials and Shape Memory Implants at the Siberian Institute of Physics and Technology named after Academician V.D. Kuznetsov, National Research Tomsk State University (Tomsk, Russia) of mandibular endoprostheses made taking into account the individual characteristics of defects, on the basis of porous, nonporous and textile titanium nickelide, surgical treatment of 72 patients aged 7 to 76 years, with pathology of the temporomandibular joint, inflammatory changes, traumatic injuries, tumor and tumor-like conditions, anomalies of the mandibular bone from intraoral or extraoral accesses without immobilization of the lower jaw with the use of fixing structures in the form of titanium nickelide staples with shape memory effect.Results. The use of titanium nickelide-based endoprostheses in the surgical removal of mandibular defects of various sizes, configurations and etiology to obtain satisfactory results in all operated patients. 64 (88.9%) patients received primary wound healing, in 6 cases the wounds healed a second time, 3 patients are required repeated arthroplasty.Conclusion. Due to the biocompatibility of titanium nickelide with body tissues, individual mandibular endoprostheses based on it, after being placed in the defect zone, function for a long time in the body, ensuring full restoration of the functional capabilities of the dental apparatus and minimizing all types of complications inherent in this type of intervention.