Lower limb deep vein thrombosis in COVID-19 patients admitted to intermediate care respiratory units

Abstract

COVID-19 has been associated with an increased risk of thrombotic events; however, the reported incidence of deep vein thrombosis varies depending, at least in part, on the severity of the disease. Aim of this prospective, multicenter, observational study was to investigate the incidence of lower limb deep vein thrombosis as assessed by compression ultrasound in consecutive patients admitted to three pulmonary medicine wards designated to care for patients with COVID-19 related pneumonia, with or without respiratory failure but not requiring admission to an intensive care unit. Consecutive patients admitted between March 27 and May 6, 2020 were enrolled. Patients were excluded if they were less than 18-year-old or if compression ultrasound could not be performed for any reason. Patients were assessed at admission (t0) and after 7 days (t1). Major and non-major clinically relevant bleedings were recorded. Sixty-eight patients were enrolled. Two were excluded due to anatomical abnormalities that prevented compression ultrasound; sixty patients were retested at (t1). All patients were started on antithrombotic prophylaxis, unless therapeutic anticoagulation was required. Deep vein thrombosis as assessed by compression ultrasound was observed in 2 patients (3%); one of them was later deemed to represent a previous episode. No new episodes were detected at t1. One major and 2 non-major clinically relevant bleedings were observed. In the setting of patients with COVID-related pneumonia not requiring admission to an intensive care unit, the incidence of deep vein thrombosis is low and our data support not screening asymptomatic patients.

Trombose venosa profunda em pacientes com COVID-19:

“…Um estudo observacional prospectivo realizado em pacientes em cuidado intensivo na França demonstrou que a prevalência da trombose venosa em pacientes com 24 .…”

Major coagulation disorders and parameters in COVID-19 patients

“…Similar to venous thromboembolism, deep vein thrombosis has also reported in COVID-19 patients in which blood clotting occurs deep in the veins [ 20 ]. The high prevalence of deep vein thrombosis and its association with adverse outcomes of COVID-19 has been reported in patients [ 21 ].…”

Avaliação da incidência de tromboembolismo venoso em pacientes com Covid-19 internados em uma unidade de terapia intensiva

“…Em estudo realizado na Itália sobre COVID-19, também se percebeu uma maior prevalência de TVP em pacientes do sexo masculino, representando 57,6% e hipertensos 63,3% 12 . Em outra pesquisa, observou-se a preponderância de homens com alta prevalência de obesidade e outras comorbidades médicas crônicas, especialmente doenças cardiovasculares, hipertensão e diabetes mellitus 13 .…”