Lower limb peripheral NIRS parameters during a vascular occlusion test: An experimental study in healthy volunteers

Fellahi, Jean-Luc; Butin, G.; Zamparini, G.; Fischer, Marc-Olivier; Gérard, Jean-Louis; Hanouz, Jean‐Luc

doi:10.1016/j.annfar.2013.11.014

Cited by 36 publications

(32 citation statements)

References 29 publications

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“…; Fellahi et al . ). Although the thenar eminence is useful for bedside measurement with intensive care patients, exploration of different measurement sites of S tO 2 may provide more insight into the relationship between micro‐ and macrocirculatory responses to occlusion for a region that may be more sensitive to evaluate the effect of interventions (i.e.…”

Section: Introductionmentioning

confidence: 97%

“…More specifically, it has recently been reported that static and dynamic measures of tissue oxygen saturation (StO 2 ) during a vascular occlusion test (VOT) can help in evaluating peripheral perfusion in some clinical settings (Kragelj et al 2001;Creteur et al 2007;Doerschug et al 2007;Mayeur et al 2011;Lipcsey et al 2012;De Backer et al 2013). The VOT is commonly performed on the thenar eminence (Doerschug et al 2007;Gómez et al 2008;Bezemer et al 2009;Bopp et al 2011;Mayeur et al 2011;Lipcsey et al 2012), with very few studies applying this technique on other sites (Kragelj et al 2001;Fellahi et al 2014). Although the thenar eminence is useful for bedside measurement with intensive care patients, exploration of different measurement sites of StO 2 may provide more insight into the relationship between micro-and macrocirculatory responses to occlusion for a region that may be more sensitive to evaluate the effect of interventions (i.e.…”

Section: Introductionmentioning

confidence: 99%

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Vascular responsiveness determined by near‐infrared spectroscopy measures of oxygen saturation

McLay

Fontana

Nederveen

et al. 2015

Experimental Physiology

138

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New Findings r What is the central question of this study?Can the near-infrared spectroscopy (NIRS)-derived reperfusion rate (slope 2) of tissue oxygen saturation (StO 2 ) be correlated with flow-mediated dilation (FMD), the commonly used method to assess vascular endothelial function? r What is the main finding and its importance?The present data were able to establish a correlation between the reperfusion rate of StO 2 and percentage FMD in healthy young men. These data suggest that NIRS-derived slope 2 StO 2 can be used as a measure of vascular endothelial function.Vascular impairments at the macro-and microcirculatory levels are associated with increased risk for cardiovascular disease. Flow-mediated dilation (FMD) is currently the most widely used method for non-invasive assessment of vascular endothelial function. Recently, near-infrared spectroscopy (NIRS)-derived measures of tissue oxygen saturation (StO 2 ) have been used to characterize the dynamic response of local tissue perfusion to a brief period of ischaemia. The purpose of the present study was to establish correlations between the reperfusion rate of StO 2 and FMD. Ultrasound-derived FMD was quantified after 5 min of distal cuff occlusion of the popliteal artery in 20 healthy young men (26 ± 3 years old). Triplicate measurements of end-diastolic arterial diameter were made every 15 s after cuff release, and FMD response was calculated as the greatest percentage change in diameter from baseline (%FMD). The StO 2 was measured using NIRS throughout the duration of each test. Two consecutive FMD tests were performed, separated by 30 min of rest, and were averaged for %FMD and StO 2 . The %FMD was significantly correlated with the reperfusion slope of StO 2 after cuff release (slope 2 StO 2 ; r = 0.63, P = 0.003). In conclusion, the present study established a correlation between slope 2 StO 2 and %FMD in healthy young men. These data suggest that NIRS-derived slope 2 StO 2 can be used as a measure of vascular endothelial function.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Vascular responsiveness determined by near‐infrared spectroscopy measures of oxygen saturation

McLay

Fontana

Nederveen

et al. 2015

Experimental Physiology

138

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“…Moreover, the additive information regarding vasodilatory stimulus that this approach provides, compared with other more traditional measures, shines new light on an old problem and opens new possibilities for cardiovascular research across the health continuum. The NIRS-derived post-occlusion tissue oxygen saturation recovery kinetics has previously been used to assess peripheral microvascular function across the disease continuum, including healthy young subjects (Bopp et al 2011(Bopp et al , 2014Fellahi et al 2014), patients with peripheral artery disease (Kragelj et al 2001), tobacco users (Zamparini et al 2015) and patients with sepsis (Doerschug et al 2007;Mayeur et al 2011). To our knowledge, this is the first study to use this approach to assess age-related microvascular dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…, ; Fellahi et al . ), patients with peripheral artery disease (Kragelj et al . ), tobacco users (Zamparini et al .…”

Section: Introductionmentioning

confidence: 99%

“…skeletal muscle) directly, increasing its overall specificity. To date, several studies have evaluated tissue oxygen saturation (S tO 2 ) kinetics following circulatory occlusion in healthy young subjects (Bopp et al 2011(Bopp et al , 2014Fellahi et al 2014), patients with peripheral artery disease (Kragelj et al 2001), tobacco users (Zamparini et al 2015) and patients with sepsis (Doerschug et al 2007;Mayeur et al 2011). The results suggest that NIRS-derived post-occlusion tissue oxygen saturation kinetics is a robust and easy-to-use approach to evaluate vascular function in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Age‐related microvascular dysfunction: novel insight from near‐infrared spectroscopy

Rosenberry

Munson

Chung

et al. 2017

Experimental Physiology

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What is the central question of this study? Can near-infrared spectroscopy (NIRS)-derived post-occlusion tissue oxygen saturation recovery kinetics be used to study age-related impairments in microvascular function? What is the main finding and its importance? Using a previously established 5 min cuff occlusion protocol, we found that NIRS-derived indices of microvascular function were markedly reduced in elderly compared with young participants. However, when we controlled for the absolute level of vasodilatory stimulus and matched the tissue desaturation level between groups, we found similar responses in young and elderly participants. Overall, these data highlight the important role NIRS can serve in clinical vascular biology, but also establish the need for assessing tissue ischaemia during cuff occlusion protocols. Near-infrared spectroscopy (NIRS) has emerged as a promising tool to evaluate vascular reactivity in vivo. Whether this approach can be used to assess age-related impairments in microvascular function has not been tested. Tissue oxygen saturation (StO2) post-occlusion recovery kinetics were measured in two distinct age groups (<35 and >65 years of age) using NIRS placed over the flexor digitorum profundus. Key end-points included the following: (i) the desaturation rate during cuff occlusion; (ii) the lowest StO2 value obtained during ischaemia (StO2min); (iii) StO2 reperfusion rate; (iv) the highest StO2 value reached after cuff release (StO2max); and (v) the reactive hyperaemia area under the curve (AUC). At first, using a conventional 5 min cuff occlusion protocol, the elderly participants achieved a much slower rate of oxygen recovery (1.5 ± 0.2 versus 2.5 ± 0.2% s ), lower StO2max (85.2 ± 2.9 versus 92.3 ± 1.5%) and lower reactive hyperaemia AUC (2651.8 ± 307.0 versus 4940.0 ± 375.8% s ). However, owing to a lower skeletal muscle resting metabolic rate, StO2min was also significantly attenuated in the elderly participants compared with the young control subjects (55.7 ± 3.5 versus 41.0 ± 3.4%), resulting in a much lower ischaemic stimulus. To account for this important difference between groups, we then matched the level of tissue ischaemia in a subset of young healthy participants by reducing the cuff occlusion protocol to 3 min. Remarkably, when we controlled for tissue ischaemia, we observed no differences in any of the hyperaemic end-points between the young and elderly participants. These data highlight the important role NIRS can serve in vascular biology, but also establish the need for assessing tissue ischaemia during cuff occlusion protocols.

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Verwendung der Nahinfrarotspektroskopie zur Kontrolle der Extremitätenperfusion unter venoarterieller ECMO-Therapie

et al. 2017

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Patients undergoing peripheral venoarterial extracorporeal membrane oxygenation have a high risk of lower limb ischemia. In general, regular controls are carried out based on clinical and laboratory parameters in order to quickly detect and treat complications. These controls are challenging due to states of shock, nonpulsatile flow and vasopressor therapy. As additional monitoring the use of near-infrared spectroscopy (NIRS) is described in the literature as being very successful in detecting ischemia. The present article describes the use and possible limitations of NIRS for the diagnostics of peripheral ischemia.

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Lower limb peripheral NIRS parameters during a vascular occlusion test: An experimental study in healthy volunteers

Cited by 36 publications

References 29 publications

Vascular responsiveness determined by near‐infrared spectroscopy measures of oxygen saturation

Vascular responsiveness determined by near‐infrared spectroscopy measures of oxygen saturation

Age‐related microvascular dysfunction: novel insight from near‐infrared spectroscopy

Verwendung der Nahinfrarotspektroskopie zur Kontrolle der Extremitätenperfusion unter venoarterieller ECMO-Therapie

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