Lower Serum Level of Adiponectin Is Associated with Increased Risk of Endoscopic Erosive Gastritis

Abstract

Lower serum level of adiponectin may increase the risk of endoscopic erosive gastritis, independently of BMI. Our findings facilitate further study to clarify the role of hypoadiponectinemia in erosive gastritis.

Is Obesity a New Risk Factor for Gastritis?

“…An association between obesity and upper gastrointestinal symptoms, such as abdominal pain and vomiting, was recently demonstrated [4,5]. Moreover, the results of several recent studies, including ours, demonstrate the potential effects of obesity on gastritis [6,7,8,9]. Here, we first review recent studies on the relationship between obesity and gastritis.…”

Endoscopic Gastritis: What Does It Mean?

“…Erosive gastritis is diagnosed when endoscopy reveals small elevations with central umbilication, mimicking octopus' suckers, which are usually observed in the antrum. It can also be defined as a flat or minimally depressed white spot surrounded by a reddish area that is sometimes accompanied by small superficial bleeding [3]. Since the distinction between erosion and tiny shallow ulcer is arbitrary, the latter might be included under the term ''erosion.''…”

“…Since the distinction between erosion and tiny shallow ulcer is arbitrary, the latter might be included under the term ''erosion.'' When the erosion is elevated, it is generally defined as verrucous gastritis or gastritis varioliformis rather than as erosive gastritis.In this issue of Digestive Diseases and Sciences, Yamamoto et al [3] provide an interesting finding that lower serum levels of adiponectin are associated with an increased risk of endoscopic erosive gastritis, independently of body mass index (BMI). BMI is known to be associated with abnormal upper endoscopic findings, such as erosive gastritis, gastric ulcer, duodenal ulcer, and reflux esophagitis [4].…”

“…In this issue of Digestive Diseases and Sciences, Yamamoto et al [3] provide an interesting finding that lower serum levels of adiponectin are associated with an increased risk of endoscopic erosive gastritis, independently of body mass index (BMI). BMI is known to be associated with abnormal upper endoscopic findings, such as erosive gastritis, gastric ulcer, duodenal ulcer, and reflux esophagitis [4].…”

“…For example, erosive gastritis is linked to obesity and hypoadiponectinemia [3], whereas open-type atrophic gastritis, metaplastic gastritis, and nodular gastritis are linked to gastric cancer [6][7][8][9][10][11][12][13][14]. Therefore, one must pay attention to the diagnostic features of gastritis during the endoscopic examination.…”