LPP polymorphisms are risk factors for allergic rhinitis in the Chinese Han population

Wang, Haiying; Han, Ho Jae; Niu, Yongliang; Li, Xiaobo; Du, Xintao; Wang, Qiang

doi:10.1016/j.cyto.2022.156027

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…that variants of genes were associated with the susceptibility to AR. Wang et al found that LPP (rs2030519, rs6780858 and rs2990220) were related to AR risk (Wang et al, 2022). Lian et al observed that Related Orphan Receptor A (RORA)-rs10519067, rs10519068, and rs11071559-were associated with AR patients with BMI ≤24 kg/m 2 (Lian et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

CLEC16A variants conferred a decreased risk to allergic rhinitis in the Chinese population

Niu

Wang

et al. 2022

Front. Genet.

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Background: Allergic rhinitis (AR) is a chronic respiratory disease. Hereditary factors played a key role in the pathogenesis of the AR. This study investigated the association between CLEC16A variants and AR risk in the Chinese population.Methods: We applied Agena MassARRAY technology platform to genotype five single nucleotide polymorphisms (SNPs) located in CLEC16A in 1004 controls and 995 cases. The association between CLEC16A SNPs (rs2286973, rs887864, rs12935657, rs11645657 and rs36045143) and AR risk were calculated by logistic regression analysis, with odds ratio (OR) and 95% confidence interval (CI). False-positive report probability (FPRP) was also used to assess the significant results to reduce false positives. Multifactor dimensionality reduction (MDR) was completed to assess the interaction between CLEC16A variants to predict AR risk.Results: Totally, CLEC16A (rs887864, rs12935657, rs2286973, rs11645657 and rs36045143) were significantly associated with AR risk. Therein, rs2286973, rs11645657 and rs36045143 were related to a decreased risk of AR in the people ≤ 43 years old, females and the people with BMI≤24, respectively. And rs887864 and rs12935657 were also associated with a decreased susceptibility of AR in the people >43 years old. Meanwhile, in the results of region stratification, rs887864 conferred a reduced risk to AR in the people from loess hilly area.Conclusion:CLEC16A variants conferred a decreased risk to AR in the Chinese population.

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Section: Discussionmentioning

confidence: 99%

CLEC16A variants conferred a decreased risk to allergic rhinitis in the Chinese population

Niu

Wang

et al. 2022

Front. Genet.

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Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease in Subjects from Punjab, Pakistan

Zulfiqar,

Fiaz,

Khan

et al. 2024

Genes

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Celiac disease (CD) is a complicated autoimmune disease that is caused by gluten sensitivity. It was commonly believed that CD only affected white Europeans, but recent findings show that it is also prevailing in some other racial groups, like South Asians, Caucasians, Africans, and Arabs. Genetics plays a profound role in increasing the risk of developing CD. Genetic Variations in non-HLA genes such as LPP, ZMIZ1, CCR3, and many more influence the risk of CD in various populations. This study aimed to explore the association between LPP rs1464510 and ZMIZ1 rs1250552 and CD in the Punjabi Pakistani population. For this, a total of 70 human subjects were selected and divided into healthy controls and patients. Genotyping was performed using an in-house-developed tetra-amplification refractory mutation system polymerase chain reaction. Statistical analysis revealed a significant association between LPP rs1464510 (χ2 = 4.421, p = 0.035) and ZMIZ1 rs1250552 (χ2 = 3.867, p = 0.049) and CD. Multinomial regression analysis showed that LPP rs1464510 A allele reduces the risk of CD by ~52% (OR 0.48, CI: 0.24–0.96, 0.037), while C allele-carrying subjects are at ~2.6 fold increased risk of CD (OR 3.65, CI: 1.25–10.63, 0.017). Similarly, the ZMIZ1 rs1250552 AG genotype significantly reduces the risk of CD by 73% (OR 0.26, CI: 0.077–0.867, p = 0.028). In summary, Genetic Variations in the LPP and ZMIZ1 genes influence the risk of CD in Punjabi Pakistani subjects. LPP rs1464510 A allele and ZMIZ1 AG genotype play a protective role and reduce the risk of CD.

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LPP polymorphisms are risk factors for allergic rhinitis in the Chinese Han population

Cited by 2 publications

References 34 publications

CLEC16A variants conferred a decreased risk to allergic rhinitis in the Chinese population

CLEC16A variants conferred a decreased risk to allergic rhinitis in the Chinese population

Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease in Subjects from Punjab, Pakistan

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