LPS from Porphyromonas gingivalis increases the sensitivity of contractile response mediated by endothelin-B (ETB) receptors in cultured endothelium-intact rat coronary arteries

Minimally modified LDL upregulates endothelin type B receptors in rat coronary artery via ERK1/2 MAPK and NF-κB pathways

“…The results agree well with our previous studies demonstrating that organ culture of rat mesenteric and cerebral arteries induces upregulation of ET B receptors in the smooth muscle cells, and this upregulation occurs via activation of NF-κB [14] and ERK1/2 MAPK [29,43]. When LPS is added to the culture, the upregulation of ET B receptors can be further increased in the coronary arteries [44]. Similar results are seen in rat mesenteric arteries when lipid-soluble smoke particles are presented in the process of organ culture.…”

Endothelin‐1 Stimulates Proinflammatory Cytokine Expression in Human Periodontal Ligament Cells via Mitogen‐Activated Protein Kinase Pathway

“…However, the ET A and ET B receptor antagonists, which block the ET‐1 signal to the cells, greatly inhibited the ET‐1–induced upregulation of both cytokine mRNA expression and protein levels in H‐hPDL and P‐hPDL cells. Previously, there have been several reports on the inhibition of inflammatory development by ET receptor antagonists in various diseases 27‐31 . Thus, the inhibition of ET‐1 signaling to cells presents a potential therapeutic approach for controlling the inflammatory response, and treatment with ET A and ET B receptor antagonists may contribute to regulating the inflammation of periodontal tissue.…”

The effect of Porphyromonas gingivalis lipopolysaccharide on pregnancy in the rat

“…In the present study, even in the face of hypertension, foetal growth restriction or foetal death still occurred in some foetuses, suggesting that also other factors may play a role. Alternatively, it is also possible that the increased systolic blood pressure was the consequence of a direct effect of Pg‐LPS on the endothelium, for it has recently been shown that exposure to Pg‐LPS increases the sensitivity of contractile responses mediated by endothelin‐1 (ET‐1) in cultured rat coronary arteries (Ghorbani et al , ). Because ET‐1 is a strong vasoconstrictor produced by endothelial cells that has been associated with hypertension during pregnancy in both animal and human studies (George and Granger, ), this may also be a possible mechanism by which Pg‐LPS directly increased systolic blood pressure in pregnant rats in the present study.…”