LPS-induced inflammation disorders bone modeling and remodeling by inhibiting angiogenesis and disordering osteogenesis in chickens

Tong, Xili; Zhang, Jialü; Li, Jiakui

doi:10.1007/s00011-020-01361-x

Cited by 6 publications

(6 citation statements)

References 35 publications

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“…The expression changes of VEGF are closely related to the processes of synovial inflammation, chondrocyte apoptosis, and cartilage degeneration [ 41 – 43 ]. On the one hand, the proliferation and migration of VEGF lead to bone and cartilage damage [ 44 , 45 ], while the increase in serum VEGF levels breaks the balance of bone metabolism in the body, inhibits bone resorption, enhances bone formation, and eventually leads to fibrosis and ossification of the sacroiliac joints, spine and nearby tendons, the ligament-bone attachment points, and new bone formation [ 46 ]. PTGS2 is also known as cyclooxygenase 2, and this gene serves as an important target in the inflammation process, which can convert arachidonic acid into PGH2 and cause inflammation [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Duhuo Jisheng Decoction in Treating Ankylosing Spondylitis: Clinical Evidence and Potential Mechanisms

Wang

Zhou

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Duhuo Jisheng Decoction (DHJSD) is an ancient compound widely used in the treatment of ankylosing spondylitis (AS). However, its efficacy is controversial, and its mechanism of action is not clear enough. Using meta-analysis and network pharmacology, our study evaluated the clinical efficacy of DHJSD in the treatment of AS and explored its mechanisms of action. Methods. We searched medical databases, including Embase, PubMed, the China National Knowledge Infrastructure databases, Wanfang, and the Chinese Scientific Journal Database, to identify studies that met the inclusion criteria. RevMan 5.3 software was used for the meta-analysis. The compounds and the potential protein targets of DHJSD were obtained from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database and analysis platform. AS was treated as a search query in the NCBI, PharmGKB, TTD, DrugBank, and OMIM databases to obtain disease-related genes. The overlapping targets of DHJSD and AS were identified, and then Gene Ontology functional enrichment and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed. Cytoscape was employed to construct a drug-compound-target network and a protein-protein interaction (PPI) network. CytoHubba was utilized to select the hub genes. Results. A total of 10 studies involving 860 participants were included in the meta-analysis. Compared with the control, DHJSD treatment significantly improved clinical symptoms; reduced the erythrocyte sedimentation rate (ESR), the C-reactive protein (CPR), and interleukin 6 (IL-6) levels; increased the degree of motion of the chest; reduced the visual analog scale (VAS) pain score; reduced Schober’s test values; reduced the finger-to-floor distance; reduced the duration of morning stiffness. However, the differences were not statistically significant in the Bath Ankylosing Spondylitis Functional Index scores, the Bath Ankylosing Spondylitis Disease Activity Index scores, the bone Gla-containing protein (BGP) levels, or the bone alkaline phosphatase (BALP) levels. In terms of adverse events, DHJSD treatment of AS reduced the incidence of gastrointestinal events, the incidence of skin events, and the incidence of abnormal liver function; however, there was no statistically significant reduction in the incidence of adverse renal function events. Subgroup analysis showed that in the treatment of AS, the clinical effect of DHJSD for AS was better than that of the controls for both treatment durations, ≤2 months and >2 months. A total of 178 active compounds and 47 related potential targets were identified for DHJSD in the treatment of AS, including four hub genes (CXCL8, PTGS2, VEGFA, and STAT3). The core active ingredients of DHJSD in the treatment of AS were mainly quercetin, kaempferol, licochalcone A, and isorhamnetin. DHJSD treatment of AS-related pathways mainly involved the IL-17 signaling pathway, the TNF signaling pathway, and the rheumatoid arthritis signaling pathway. Conclusion. The above results suggest that DHJSD acts on AS through multiple targets, components, and pathways with significant clinical efficacy. Future studies may further explore the active components of DHJSD.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Duhuo Jisheng Decoction in Treating Ankylosing Spondylitis: Clinical Evidence and Potential Mechanisms

Wang

Zhou

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…S4 ). Many reports have suggested that RUNX2 is an important cytokine for early osteogenic differentiation [ 50 , 51 ]. On the one hand, RUNX2 can promote bone formation by influencing osteogenic differentiation indicators, such as ALP through its downstream gene OSX [ 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Hydroxyapatite composited PEEK with 3D porous surface enhances osteoblast differentiation through mediating NO by macrophage

Liu

Ouyang

Chen

et al. 2021

Regenerative Biomaterials

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The adverse immune response mediated by macrophages is one of the main factors that are prone to lead poor osseointegration of polyetheretherketone (PEEK) implants in clinic. Hence, endowing PEEK with immunomodulatory ability to avoid the adverse immune response becomes a promise strategy to promote bone repair. In this work, sulfonation and hydrothermal treatment were used to fabricate a three-dimensional porous surface on PEEK and hydroxyapatite composited PEEK. The hydroxyapatite composited PEEK with three-dimensional porous surface inhibited macrophages polarizing to M1 phenotype and down-regulated iNOS protein expression, which led to a nitric oxide concentration reduction in culture medium of mouse bone marrow mesenchymal stem cells (mBMSCs) under co-culture condition. The decrease of nitric oxide concentration could help to increase bone formation related OSX and ALP genes expressions and decrease bone resorption related MMP-9 and MMP-13 genes expressions via cAMP-PKA-RUNX2 pathway in mBMSCs. In summary, the hydroxyapatite composited PEEK with three-dimensional porous surface has the potential to promote osteogenesis of PEEK through immunomodulation, which provides a promising strategy to improve the bone repair ability of PEEK.

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“…Cytokines IL- 6 and PGE 2 induce each other's production and prompt osteoclastogenesis through inhibiting OPG production and upregulating RANK production, indicating an inflamed state could perpetuate bone loss and weakening ( 91 ). Tong et al ( 105 ) explored the relationship between inflammation and bone metabolism in broilers through an LPS challenge. LPS challenged birds had shorter tibial length and reduced tibial weight relative to control birds, as well as increased levels of pro-inflammatory AA, derived cytokines (IL-6, TNF α) and RANKL and decreased OPG levels ( 105 ).…”

Section: Omega-3 Fatty Acids In Broiler Breeder Diets and The Effect On Progenymentioning

confidence: 99%

“…Tong et al ( 105 ) explored the relationship between inflammation and bone metabolism in broilers through an LPS challenge. LPS challenged birds had shorter tibial length and reduced tibial weight relative to control birds, as well as increased levels of pro-inflammatory AA, derived cytokines (IL-6, TNF α) and RANKL and decreased OPG levels ( 105 ). Cytokine IL-6 also decreased the height and proportion of the tibial growth plate, suppressing bone growth.…”

Section: Omega-3 Fatty Acids In Broiler Breeder Diets and The Effect On Progenymentioning

confidence: 99%

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Influence of Feeding Omega-3 Polyunsaturated Fatty Acids to Broiler Breeders on Indices of Immunocompetence, Gastrointestinal, and Skeletal Development in Broiler Chickens

Thanabalan

Kiarie

2021

Front. Vet. Sci.

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Modern broiler chickens are associated with rapid growth rates and superior feed efficiency. However, they are also susceptible to physiological and metabolic disorders (e.g., skin lesions, lameness, sudden death, enteric diseases, myopathies) that exert substantial economic losses to producers. This is further exacerbated by consumer pressure and mandated cessation of production practices such as indiscriminate use of antimicrobial growth promoters. Manipulation of broiler breeder (BB) nutrition and management can influence chick quality, robustness, and resilience to stressors in the production environment. The present review examines the role of feeding BB functional polyunsaturated omega-3 fatty acids (n-3 PUFA) and subsequent impact on the indices of immunocompetence, skeletal, and gastrointestinal (GIT) development in broiler chickens. Research in mammalian and avian models led evidence that perinatal feeding of long chain n-3 PUFA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) engender transgenerational effects through regulation of a variety of biological processes including development of vital organs such as skeleton, brain and GIT. It is shown that feeding poultry breeders n-3 PUFA decreases inflammatory states and enriches hatching eggs with n-3 PUFA and immunoglobulins. Further evidence also shows that after 15 days of incubation, chicken embryos preferentially utilize long chain n-3 PUFA-critical for optimal cell, tissues, and organ development. Enrichment of n-3 PUFA in newly hatchling tissues reduce proinflammatory eicosanoids with consequences of enhanced bone mineralization. Dietary n-3 PUFA also modulates breeder GIT microbiota with consequences of microbial colonization and succession in chicks. As well, research shows that feeding poultry breeders n-3 PUFA bolsters progeny immunocompetence through enhanced passive immunity and antibody titres against routine vaccination. In conclusion, it appears that chicks may benefit from the incorporation of n-3 PUFA in the breeder diets; however, little attention is paid to fatty acids composition in breeder nutrition. We also highlight gaps in knowledge and future research perspectives.

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LPS-induced inflammation disorders bone modeling and remodeling by inhibiting angiogenesis and disordering osteogenesis in chickens

Cited by 6 publications

References 35 publications

Efficacy of Duhuo Jisheng Decoction in Treating Ankylosing Spondylitis: Clinical Evidence and Potential Mechanisms

Efficacy of Duhuo Jisheng Decoction in Treating Ankylosing Spondylitis: Clinical Evidence and Potential Mechanisms

Hydroxyapatite composited PEEK with 3D porous surface enhances osteoblast differentiation through mediating NO by macrophage

Influence of Feeding Omega-3 Polyunsaturated Fatty Acids to Broiler Breeders on Indices of Immunocompetence, Gastrointestinal, and Skeletal Development in Broiler Chickens

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