LSD: Injection Early in Pregnancy Produces Abnormalities in Offspring of Rats

Abstract

One of five rats given a single subcutaneous injection of lysergic acid diethylamide (LSD) early in pregnancy appeared to abort early; two delivered stunted stillborn offspring at term, one delivered a littler of seven healthy and one underdeveloped young, and the last one delivered an apparently normal litter. All five matched controls, given saline injections, went to term and delivered healthy litters of 11 to 16 offspring; there were no abortions and no stillbirths. In a replicate experiment, one of five rats given LSD on the 4th day of gestation aborted, two delivered some stillborn offspring, one gave an abnormally small litter of four, and the last one produced an apparently normal litter of ten. All matched controls delivered healthy litters, totaling 66. Some surviving offspring treated with LSD failed to develop as well as control animals. Treatment of five additional rats with LSD late in pregnancy had no obvious effect on the offspring.

The Effect of LSD-25 on the Chromosomes of Children Exposed in Utero

“…Only a well-controlled study will answer this question. In animals (rats, hamsters and mice) there is documentation of teratogenesis as a direct consequence of LSD injection during pregnancy [1,4,16]. WARKANY and TAKACS [35] could not confirm the positive findings in rats.…”

Social and Medical Aspects of Illicit Use of LSD

“…These effects have been demonstrated in rats by Alexander,3 in mice by Auerbach and his co-workers,6 in hamsters by Gaber44 and in rabbits by Fabro and Sieber;35 however a study by Warkany and Takacs'o3 showed no teratogenicity in rates. Two reports have suggested possible effects on human embryos of mothers who had taken LSD and these deserve direct quotes.…”

“…When examining the social and medical aspects of illicit use of LSD, this paper will look at five questions: (1) what is the nature and the extent of this phenomenon, especially in the United States in 1969; (2) who are the people taking LSD outside the treatment situation; (3) what is the nature of the LSD experience that is being claimed; (4) what are the dangers to the individual or to the society; (5) what is the nature of society's reaction to this phenomenon.…”

LSD- und Cannabis-Konsum während der frühen Schwangerschaft mit gutem perinatalen Ausgang

“…Bei Ratten [18,19] wurden in Studien mit relativ wenigen Tieren (n = 10) überwiegend Schwangerschaften beobachtet, die mit Aborten oder Totgeburten endeten; ausgetragene Jungtiere waren untergewichtig. Die einmalig am 4.…”