&lt;b&gt;Value of Left Atrial Function in Predicting Exercise Capacity in Heart Failure With Moderate to Severe Left Ventricular Systolic Dysfunction&lt;/b&gt;

Terzi, Sait; Dayı, Şennur Ünal; Akbulut, Tamer; Sayar, Nurten; Bilsel, Tuba; Tangurek, Burak; Akgöz, Haldun; Köse, Hacer; Yilmazer, Serdar; Yeşilçimen, Kemal

doi:10.1536/ihj.46.123

Cited by 37 publications

(22 citation statements)

References 33 publications

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“…LA ejection fraction was directly related to peak oxygen consumption (r = 0.55), but the most strongly correlation was with LA filling fraction (r = 0.67). Similar were the findings in the study of Terzi et al, on 44 patients with dilated cardiomyopathy [74].…”

Section: Exercise Capacitysupporting

confidence: 91%

Left atrial remodelling contributes to the progression of asymptomatic left ventricular systolic dysfunction to chronic symptomatic heart failure

et al. 2007

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Systolic heart failure (HF) is a progressive disorder that often begins with asymptomatic left ventricular (LV) systolic dysfunction and culminates in symptoms from fluid overload and poor end-organ perfusion. The progression to symptomatic HF is accompanied by marked activation of neurohormonal and cytokine systems, as well as a series of adaptive LV anatomical and functional changes, collectively referred to as LV remodelling. However, the mechanisms underlying symptom appearance have not been delineated and the weight of experimental and clinical evidence suggests that the development of symptomatic HF occurs independently of the haemodynamic status of the patient. The left atrium is a muscular chamber strategically located between the left ventricle and the pulmonary circulation with important mechanical function (modulation of LV filling), which is closely coupled with its endocrine (atrial natriuretic peptide synthesis and secretion) and regulatory (contribution to the control of sympathetic activity and vasopressin release) functions. In this narrative review we provide evidence supporting the concept that left atrial dilation and systolic dysfunction (left atrial remodelling) contributes to the progression of asymptomatic LV dysfunction to chronic symptomatic systolic HF as it is a prerequisite for the development of the pulmonary congestion and marked neuronhormoral activity that characterize the symptomatic state.

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Section: Exercise Capacitysupporting

confidence: 91%

Left atrial remodelling contributes to the progression of asymptomatic left ventricular systolic dysfunction to chronic symptomatic heart failure

et al. 2007

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“…A correlation does exist, however, between exercise capacity and parameters of LV diastolic function in normal subjects and in patients with heart failure [78,79]. Several studies have demonstrated an inverse relationship between LA size and LA systolic dysfunction severity with VO 2 max in patients with heart failure and reduced LV ejection fraction [80,81,82,83,84]. These findings have recently been expanded to patients with preserved LV ejection fraction [85,86].…”

Section: La: a Marker Of Poor Exercise Capacitymentioning

confidence: 99%

The Left Atrium: From the Research Laboratory to the Clinic

et al. 2014

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Studies of left atrial (LA) function, until the latter part of the 20th century, were mostly limited to experimental animal models and to studies related to clinical research in the cardiac catheterization laboratory. For this reason, LA function has received considerably less attention than left ventricular (LV) functions, even though evidence suggests that LA myopathy and failure may exist as an isolated entity, precede and/or coexist with LV myopathy. The introduction of echocardiography and Doppler echocardiography in clinical practice has contributed significantly to our understanding of LA function and its interrelationships with the LV, aorta, pulmonary artery and other parts of the cardiovascular system. In addition, LA with the secretion of atrial natriuretic peptides is playing an important role in cardiovascular and neurohumoral homeostasis. Today, it is well known that LA structural and functional abnormalities that are present in many diseases and disorders constitute a powerful prognostic indicator. As technology (echocardiography, magnetic resonance imaging, computed tomography and others) continues to evolve, it is expected that, in the near future, LA structure and function will be routinely used as LV function is used today.

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“…However, the number of studies concerning the effects of LFES in cardiovascular rehabilitation is still very low. The effectiveness of conventional exercise training in cardiovascular rehabilitation has been sufficiently proven, [49][50][51][52][53] and LFES is not likely to replace it. But the safety and ease of application could be especially beneficial in patients with advanced CHF (III-IV).…”

Section: Ns Ns Nsmentioning

confidence: 99%

Electrical Stimulation of Skeletal Muscles An Alternative to Aerobic Exercise Training in Patients With Chronic Heart Failure?

et al. 2006

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SUMMARYThe aim of this study was to investigate whether electrical stimulation of skeletal muscles could represent a rehabilitation alternative for patients with chronic heart failure (CHF). Thirty patients with CHF and NYHA class II-III were randomly assigned to a rehabilitation program using either electrical stimulation of skeletal muscles or bicycle training. Patients in the first group (n = 15) had 8 weeks of home-based low-frequency electrical stimulation (LFES) applied simultaneously to the quadriceps and calf muscles of both legs (1 h/day for 7 days/week); patients in the second group (n = 15) underwent 8 weeks of 40 minute aerobic exercise (3 times a week). After the 8-week period significant increases in several functional parameters were observed in both groups: maximal VO 2 uptake (LFES group: from 17.5 ± 4.4 mL/kg/min to 18.3 ± 4.2 mL/kg/min, P < 0.05; bicycle group: from 18.1 ± 3.9 mL/kg/min to 19.3 ± 4.1 mL/kg/min, P < 0.01), maximal workload (LFES group: from 84.3 ± 15.2 W to 95.9 ± 9.8 W, P < 0.05; bicycle group: from 91.2 ± 13.4 W to 112.9 ± 10.8 W, P < 0.01), distance walked in 6 minutes (LFES group: from 398 ± 105 m to 435 ± 112 m, P < 0.05; bicycle group: from 425 ± 118 m to 483 ± 120 m, P < 0.03), and exercise duration (LFES group: from 488 ± 45 seconds to 568 ± 120 seconds, P < 0.05; bicycle group: from 510 ± 90 seconds to 611 ± 112 seconds, P < 0.03). These results demonstrate that an improvement of exercise capacities can be achieved either by classical exercise training or by home-based electrical stimulation. LFES should be considered as a valuable alternative to classical exercise training in patients with CHF. (Int Heart J 2006; 47: 441-453)

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<b>Value of Left Atrial Function in Predicting Exercise Capacity in Heart Failure With Moderate to Severe Left Ventricular Systolic Dysfunction</b>

Cited by 37 publications

References 33 publications

Left atrial remodelling contributes to the progression of asymptomatic left ventricular systolic dysfunction to chronic symptomatic heart failure

Left atrial remodelling contributes to the progression of asymptomatic left ventricular systolic dysfunction to chronic symptomatic heart failure

The Left Atrium: From the Research Laboratory to the Clinic

Electrical Stimulation of Skeletal Muscles An Alternative to Aerobic Exercise Training in Patients With Chronic Heart Failure?

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