<p>A New Nomogram Based on Early Postoperative NLR for Predicting Infectious Complications After Gastrectomy</p>

Abstract

Purpose: Our study aimed to construct a visible model to evaluate the risk of infectious complications after gastrectomy. Methods: The clinical data of 856 patients who underwent gastrectomy were used to retrieve medical records. Univariate and multivariate analyses were performed to correlate early postoperative NLR and operative variables with postoperative complications, and the construction of the nomogram was based on logistic regression. The concordance index and receiver operating characteristic curves were used to evaluate the model performance. Results: The postoperative infectious and noninfectious complication rates after gastrectomy were 18.5% (158/856 cases) and 12.3% (105/856 cases) respectively. Postoperative NLR (within 24 h) independently predicted the development of postoperative infectious complication. Multivariate analysis revealed that age, diabetes, body mass index (BMI), intraoperative blood transfusion and postoperative NLR were independent risk factors. The nomogram model showed a good performance in terms of predicting infectious complications after gastrectomy (concordance index=0.718). Conclusion: Age, diabetes, BMI, intraoperative blood transfusion and postoperative NLR were independent risk factors of postoperative infectious complications after gastrectomy, and a novel nomogram based on these results can be used to predict postoperative infection and has the advantages of simple application and easy access.

Comparisons of nutritional status and complications between patients with and without postoperative feeding jejunostomy tube in gastric cancer: a retrospective study

“…We found nutritional improvement in the FJT group and did not observe major effects on postoperative adverse outcomes. The NLR was measured as an indicator of systemic inflammation (29); the gradual increase in lymphocytes and the gradual decline in neutrophils occurs with systemic inflammatory reaction improvement (30). The OPNI is a simple and effective nutritional assessment and surgical risk prediction index that is currently widely used in gastrointestinal surgery (31,32).…”

Effects of Perioperative Inflammatory Response in Cervical Cancer: Laparoscopic versus Open Surgery

“…Recently, preoperative NLR and PLR have been investigated as independent prognostic factors that determine cancer progression and recurrence [ 23 , 24 ]. Additionally, postoperative NLR was reported as an independent risk factor of postoperative complications and survival in some cancers [ 18 , 19 , 20 , 25 ]. Surprisingly, few studies have reported an association between postoperative NLR changes and surgical outcomes for cervical cancer according to the surgical method.…”

Biomarcadores para determinar factores de riesgo y complicaciones postquirúrgicas en pacientes con gastrectomía. Revisión de literatura

“…Relación de la supervivencia de los pacientes con los niveles de los biomarcadores La gastrectomía hoy en día continúa siendo el tratamiento principal para los tumores gástricos y se tiene que la morbilidad de los pacientes después de someterse al procedimiento va entre el 17,4% y el 37% (6). El cambio posoperatorio de la NLR es un reflejo del comportamiento entre la respuesta inflamatoria de la persona y la respuesta inmunitaria posterior al tratamiento.…”

“…La gastrectomía es uno de los tratamientos más utilizados en la actualidad para el tratamiento de las neoplasias malignas gástricas, entre ellas destacan la gastrectomía total (GT), subtotal (GST) y parcial (6).…”

“…Se ha evidenciado que las complicaciones posquirúrgicas de la gastrectomía van del 17,4% y el 37% con un porcentaje de complicaciones infecciosas del 17,6% y el 19,8%. Las complicaciones posquirúrgicas asociadas a infección se relacionan con una recaída tumoral y un pronóstico no tan alentador en cánceres gástricos (6,7).…”