<p>A Split-Face Study Assessing the Clinical Benefit, Tolerability and Subject Satisfaction of a Dermocosmetic in Subjects with Rosacea Associated with Erythema and Sensitive Skin</p>

Abstract

This study assessed the efficacy and tolerability of M89 in patients with rosacea associated with erythema and sensitive skin. Methods: Intra-individual study in a split-face design comparing after 30 days M89 twice daily and usual skin care in 20 adult subjects with rosacea and sensitive skin. M89 contains 89% Vichy volcanic mineralizing water (VVMW) and 0.4% hyaluronic acid. It is hypoallergenic and contains no perfume and this convenes in rosacea. Contained minerals reinforce the natural defences of the skin in restoring the natural skin barrier, stimulating antioxidant activity and reducing inflammation, commonly observed in subjects with rosacea. Clinical evaluations included assessment of erythema, desquamation, papules and pustules, skin tightness, dryness, burning sensation, itching, stinging and stinging test as well as local tolerability. Instrumental evaluations included skin hydration and TEWL. Subject satisfaction was assessed at Days 15 and 30. Demodex density was assessed at Day 30. Results: A significant superiority of M89 over the standard skin care was observed for erythema, skin tightness and dryness (all P≤0.05) as early as Day 15, the skin stinging test was significantly in favour of M89 (P<0.05 at Day 15 and P<0.01 at Day 30) and for skin hydration (P<0.0001) at Day 15 and 30 with no difference in mean Demodex density between M89 and usual skin care after 30 days. Tolerance was excellent and subject satisfaction very high. Conclusion: Study results concerning M89 are encouraging for its use either alone or as an adjuvant daily skin care to topical medication in patients with persistent centrofacial erythema of rosacea with no more than 3 papules and pustules.

Evaluation of the efficacy and tolerance of a cosmetic mask containing 89% of vichy volcanic mineralizing water and hyaluronic acid after facial laser procedures

“…Instrumental assessments confirmed that M89 M improves skin hydration and reduces TEWL, thus restoring the skin barrier, as well as reducing skin redness, a symptom of erythema and inflammation, which confirms results from a split‐face study conducted by Berardesca et al published in 2020, assessing the benefits of M89 in subjects with rosacea 17 . In another recent study conducted on M89 proposed in a topical gel formulation, M89 significantly improved clinical signs and symptoms of dermatological procedures and met the investigators' and subjects' expectations 16 .…”

“…Instrumental assessments confirmed that M89 M improves skin hydration and reduces TEWL, thus restoring the skin barrier, as well as reducing skin redness, a symptom of erythema and inflammation, which confirms results from a split‐face study conducted by Berardesca et al published in 2020, assessing the benefits of M89 in subjects with rosacea. 17 In another recent study conducted on M89 proposed in a topical gel formulation, M89 significantly improved clinical signs and symptoms of dermatological procedures and met the investigators' and subjects' expectations. 16 While M89 gel applied once or twice daily allows for a significant reduction of clinical signs and symptoms following esthetic procedures over a prolonged and continued period, the use of M89 mask from right after the procedure and then twice or three‐times per week allows for an immediate improvement of clinical signs and discomfort symptoms.…”

“…It has been demonstrated that M89 improves the clinical signs and symptoms associated with various facial dermatoses, including rosacea, and even those appearing postprocedure. 16 , 17 Additionally, unpublished data confirm that M89 protects against the adhesion of pollution microparticles.…”

89% Vichy mineralizing water with hyaluronic acid is a well‐tolerated adjunct treatment that helps restore skin barrier function in dry skin‐related inflammatory dermatoses and post‐procedure skin care: A Canadian study

“…In addition, unpublished data demonstrate that M89 does not impact topical ivermectin skin penetration -encouraging results that support the use of M89 as an adjuvant to topical treatment for rosacea. 17 In conclusion, the accelerated focus on minimalist formulas with natural actives and a better comprehension of skin barrier protection during standard treatment, make M89 a suitable, efficacious choice for adjunct therapy in a variety of dermatologic conditions.…”

Use of Botulinum Toxin in Treating Rosacea: A Systematic Review

“…Skin care, sun protection, laser and pulsed light, topical or oral medications are major interventions for rosacea patients. [9][10][11] However, treatment for severe or refractory rosacea remains challenging for dermatologists. 12,13 As an injectable neuromodulator, botulinum toxin, especially type A, is useful to improve skin conditions and cosmetic defects.…”