&lt;p&gt;Basic Coagulation Profiles and Platelet Count Among &lt;em&gt;Schistosoma mansoni&lt;/em&gt;-Infected Adults Attending Sanja Primary Hospital, Northwest Ethiopia&lt;/p&gt;

Eyayu, Tahir; Zeleke, Ayalew Jejaw; Seyoum, Masresha; Worku, Ligabaw

doi:10.2147/rrtm.s244912

Cited by 10 publications

(17 citation statements)

References 31 publications

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“…The Kruskal–Wallis H-test showed that there was a significant difference in PT, APTT, and INR values between the intensity of infection and apparently healthy controls. This finding was in line with the report from Sanja Primary Hospital, Northwest Ethiopia [ 30 ]. The difference in platelet parameters between healthy controls and the intensity of S. mansoni infection in adults was not statistically significant.…”

Section: Discussionsupporting

confidence: 93%

“…Moreover, in the present study, the platelet parameters (MPV and PDW) were also significantly different between S. mansoni -infected adults and healthy controls ( P value ≤ 0.001). This finding was similar to studies done in Northwest Ethiopia [ 30 ], in Brazil [ 16 ], and Western Burkina Faso [ 31 ]. The MPV was significantly decreased among S. mansoni -infected adults compared to healthy controls.…”

Section: Discussionsupporting

confidence: 92%

“…Spearman's rank-order correlation showed that there was a significant and positive correlation between the intensity of S. mansoni infection and PT, APTT, INR, and platelet count with a correlation coefficient of 0.43, 0.255, 0.210, and 0.231, respectively, with a P value <0.05. e Kruskal-Wallis H-test showed that there was a significant difference in PT, APTT, and INR values between the intensity of infection and apparently healthy controls. is finding was in line with the report from Sanja Primary Hospital, Northwest Ethiopia [30]. e difference in platelet parameters between healthy controls and the intensity of S. mansoni infection in adults was not statistically significant.…”

Section: Discussionsupporting

confidence: 91%

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A Comparative Cross-Sectional Study of Coagulation Profiles and Platelet Parameters of Schistosoma mansoni-Infected Adults at Haik Primary Hospital, Northeast Ethiopia

Bisetegn

Feleke

Ebrahim

et al. 2022

Interdisciplinary Perspectives on Infectious Diseases

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Introduction. Schistosoma mansoni is an intravascular parasite that interacts with all components of the host blood. Nearly, 10% of S. mansoni-infected patients progress to severe hepatosplenic Schistosomiasis is characterized by periportal fibrosis, obstruction of intrahepatic veins, presinusoidal portal hypertension, and splenomegaly. Thus, this study aimed to compare the basic coagulation profiles and platelet parameters of S. mansoni-infected adults and noninfected individuals as controls at Haik Primary Hospital, Northeast Ethiopia. Methods. A comparative cross-sectional study was conducted at Haik Primary Hospital from April to June 2021. The diagnosis and intensity of S. mansoni infection was determined using the Kato–Katz technique. The coagulation profiles and platelet parameters were analyzed using coagulation and hematology analyzers. Data were analyzed using SPSS version 26.0. The Kolmogorov–Smirnov and Shapiro–Wilk tests were done to check the distribution of continuous variables. The Mann–Whitney U test was used to compare the coagulation profiles and platelet parameters. Spearman’s rank-order correlation was done to assess the correlation between the intensity of infection and coagulation profiles and platelet parameters. In all comparison, a P value <0.05 was considered statistically significant. Result. In this study, a total of 180 study participants (90 S. mansoni-infected adults and 90 controls) were included. Of the total S. mansoni-infected adults, 55.6%, 28.9%, 33, and 15.6% had light, moderate, and heavy intensity of infections, respectively. All S. mansoni-infected study participants had prolonged prothrombin time (PT) and international normalized ratio (INR). Moreover, about 80% of S. mansoni-infected adults had prolonged activated partial thromboplastin time (APTT). Thrombocytopenia was found in 26.7% of the S. mansoni-infected adults. The Mann–Whitney U test showed a statistically significant difference in coagulation profiles between S. mansoni-infected adults and healthy controls ( P -value ≤0.001). The Kruskal–Wallis H-test showed a significant difference in PT, APTT, and INR between the intensity of infection and healthy controls ( P -value <0.05). Conclusion. This study showed a prolonged coagulation time in S. mansoni-infected individuals. Thus, screening of schistosomiasis patients for hemostatic abnormalities and treating the underlying disorder is crucial.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

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A Comparative Cross-Sectional Study of Coagulation Profiles and Platelet Parameters of Schistosoma mansoni-Infected Adults at Haik Primary Hospital, Northeast Ethiopia

Bisetegn

Feleke

Ebrahim

et al. 2022

Interdisciplinary Perspectives on Infectious Diseases

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“…The thrombocytopenia recorded in S . mansoni infected-untreated mice in this study is in conjunction with several authors who demonstrated that a low blood platelet count is associated with Schistosoma infection in mice [ 58 – 60 ] or humans [ 61 , 62 ]. Stanley et al [ 60 ] reported that thrombocytopenia occurs in S .…”

Section: Discussionsupporting

confidence: 86%

Pathological and immunological evaluation of different regimens of praziquantel treatment in a mouse model of Schistosoma mansoni infection

et al. 2022

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Background One of the considerable challenges of schistosomiasis chemotherapy is the inefficacy of praziquantel (PZQ) at the initial phase of the infection. Immature schistosomes are not susceptible to PZQ at the curative dose. Here, we investigated the efficacy of different PZQ regimens administered during the initial stage of Schistosoma mansoni infection in mice. Methodology/Principal findings Two months-old mice were individually infected with 80 S. mansoni cercariae and divided into one infected-untreated control group (IC) and four PZQ-treated groups: PZQ at 100 mg/kg/day for five consecutive days (group PZQ1), PZQ at 100 mg/kg/day for 28 days (group PZQ2), PZQ at 18 mg/kg/day for 28 days (group PZQ3) and a single dose of PZQ at 500 mg/kg (group PZQ4). The treatment started on day one post-infection (p.i), and each group of mice was divided into two subgroups euthanized on day 36 or 56 p.i, respectively. We determined the mortality rate, the parasitological burden, the hepatic and intestinal granulomas, the serum levels of Th-1, Th-2, and Th-17 cytokines, and gene expression. The treatment led to a significant (p < 0.001) reduction of worm burden and egg counts in the intestine and liver in groups PZQ2 and PZQ3. On 56th day p.i, there was a significant reduction (p < 0.001) of the number and volume of the hepatic granulomas in groups PZQ2 and PZQ3 compared to group PZQ1 or PZQ4. Moreover, in group PZQ3, the serum levels of IFN-γ, TNF-α, IL-13, and IL-17 and their liver mRNA expressions were significantly reduced while IL-10 and TGF-β gene expression significantly increased. The highest mortality rate (81.25%) was recorded in group PZQ2. Conclusion/Significance This study revealed that the administration of PZQ at 18 mg/kg/day for 28 consecutive days was the optimal effective posology for treating S. mansoni infection at the initial stage in a murine model.

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“…In this instance, the coagulopathy and thrombocytopenia could represent hematologic manifestations of S. mansoni , and the coagulation profile and platelet count should be obtained to examine both the treatment response and complications. 37 …”

Section: Discussionmentioning

confidence: 99%

Fulminant Hepatitis and Ulcerative Colitis: Case Report of Ethiopian Child with Schistosomiasis and Amebiasis Co-Infection

Ketema¹,

Taye²,

Tagesse³

et al. 2022

IMCRJ

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Background Schistosomiasis is a neglected tropical disease (NTD) that affects around 200 million people worldwide, the majority of whom are children aged 5 to 15 years. It is one of the most significant public health problems in tropical and subtropical regions. Entamoeba histolytica infection is common in areas where schistosomiasis is endemic because Schistosoma mansoni infection can reduce the host’s immune response, resulting in increased morbidity. Case Presentation This is the story of a 12-year-old male adolescent from the Guji zone of the Oromia regional state of Ethiopia who presented to Hawassa University Comprehensive Specialized Hospital (HUCSH) complaining of bloody diarrhea of 1 week associated with vomiting of ingested matter of 2 weeks. He also had history of fever, chills, rigors, arthralgia, and weight loss during a 2 weeks period. Further questioning revealed that he had previously swum in a pond and had a self-limited itchy skin condition. The family said that similar cases had occurred in their town that resolved with medications provided at a local health center. Conclusion Schistosomiasis and amebiasis are major public health issues, especially in impoverished areas. Schistosomiasis presents differently clinically depending on the phase and clinical form in which it manifests, making diagnosis and management challenging. As a result, it necessitates an integrated collaboration involving clinicians, pathologists, and public health professionals. We describe ulcerative colitis (UC) ascribed to schistosomiasis and amoebiasis coinfection, and fulminant hepatitis due to schistosomiasis. As there was no report of liver abscess on sonographic scanning, hepatitis may not be due to coinfection. This case will be an alert to clinicians and public health personnel who are striving for the ultimate eradication of schistosomiasis and also teaches us that treating co-infections of both is beyond just giving praziquantel and antiamebics.

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<p>Basic Coagulation Profiles and Platelet Count Among <em>Schistosoma mansoni</em>-Infected Adults Attending Sanja Primary Hospital, Northwest Ethiopia</p>

Cited by 10 publications

References 31 publications

A Comparative Cross-Sectional Study of Coagulation Profiles and Platelet Parameters of Schistosoma mansoni-Infected Adults at Haik Primary Hospital, Northeast Ethiopia

A Comparative Cross-Sectional Study of Coagulation Profiles and Platelet Parameters of Schistosoma mansoni-Infected Adults at Haik Primary Hospital, Northeast Ethiopia

Pathological and immunological evaluation of different regimens of praziquantel treatment in a mouse model of Schistosoma mansoni infection

Fulminant Hepatitis and Ulcerative Colitis: Case Report of Ethiopian Child with Schistosomiasis and Amebiasis Co-Infection

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