<p>Clinical Study to Evaluate the Efficacy and Safety of a Hair Serum Product in Healthy Adult Male and Female Volunteers with Hair Fall</p>

Abstract

Background: Hair fall is a widespread problem among all genders, ages, and ethnicity with both physical and psychological effects. Objective: This clinical study was designed to evaluate the efficacy and safety of a hair serum formulation containing amla extract, freeze-dried coconut water, and the micronutrient selenium along with sandalwood odorant and peanut shell extract in healthy male and female volunteers with hair fall. Methods: A total of 42 subjects were enrolled and completed the study and they used the test product daily for 90 days. TrichoScan ® was used to evaluate the efficacy of the test product for improving hair growth rate, hair density, anagen hair, telogen hair, and the density of vellus and terminal hair. Hair thinning and hair fall reduction were compared to its basline by both dermatologists and subject self-assessment questionnaires. Result and Discussion: After 90 days of test product application, there was a significant improvement in hair growth rate (<0.0001), hair density (<0.0001), vellus hair density (<0.0001), and terminal hair density (<0.0001) in comparison to baseline. There was a significant reduction in hair fall with bulb (<0.0001) and without bulb (<0.0001), and hair thinning (<0.0001) compared to the baseline measurement. Adverse events were not recorded during the study. No skin intolerance was reported during the study, and the test product was considered dermatologically safe to use.

Bioactive-Based Cosmeceuticals: An Update on Emerging Trends

“…Its chemical constituents contain tetranor terpenoid lactones azadirachtin, nimbin, nimbidin, salanin, and nimbolin-B. Neem oil additionally incorporates nimbolides, oli chinolide-B, and azadiradione [ 56 , 83 ]. It is commonly used for treatment of dandruff, because it produces antifungal, antibacterial, and ache-relieving compounds that treated and ruff [ 56 ].…”

“…It contains tetranor, terpenoid, lactones azadirachtin, nimbin, nimbidin, salanin, and nimbolin-B. Neem oil additionally includesnimbolides, olichinolide-B, and azadiradione [ 56 , 83 ]. Its antibacterial of neem prevent gingivitis, and it is also used to prevent cavities and prevent bad breath [ 56 ].…”

Date Fruit and Seed in Nutricosmetics

“…The compounds of low molecular weight can penetrate the hair and improve the mechanical properties of the cortex, while high molecular weight compounds can protect the hair and prevent degradation. Majeed et al (2020) reported that coconut water increased hair density and growth in male and female volunteers, and reduced itching sensitivity [138]. Coconut water, which contains flavonoid compounds, may protect the hair follicles.…”

A single arm, exploratory and pilot study to evaluate the efficacy of a multi-component water-based herbal supplement in hair growth, density, follicle strength and hair fall in healthy male and female subjects

“…Sweet Potato (Ipomoea batatas), [8][9][10] Snake Gourd (Trichosanthes Anguina L), 4,[11][12][13] False Daisy (Eclipta prostrata), [14][15][16] Curry Leaves (Murraya koenigii), [17][18][19] Indian Gooseberry (Phyllanthus emblica), [20][21][22] Almond (Prunus dulcis), 23,24 Walnut (Juglans regia), 24 Groundnut (Arachis hypogaea), 25 Flaxseed (Linum usitatissimum), [26][27][28] Chia Seed (Salvia hispanica), 29,30 Lemon (Citrus x limon), [31][32][33] Chickpea (Cicer arietinum), 34 Cinnamon (Cinnamomum Zeylanicum Blume), 35,36 Guava (Psidium guajava), [37][38][39] Cumin (Cumin cyminum), 40,41 Spinach (Spinacia oleracea). 42…”