&lt;p&gt;Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes&lt;/p&gt;

Deng, Xia; Zhao, Li; Guo, Chen; Yang, Licong; Wang, Dong; Li, Yanyan; Xia, Hong; Wang, Chenxi; Cai, Zhensheng; Li, Lian; Zhao, Zhicong; Yuan, Guoyue

doi:10.2147/dmso.s283413

Cited by 21 publications

(17 citation statements)

References 36 publications

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“…13,15 Regarding evidence for association of asprosin and metabolic syndrome components, tell now its obscure and not well studied. 16 In this study, it was elucidated that women with metabolic syndrome were had markedly elevated serum asprosin concentrations, similarly to a finding conducted from newly established study done in patients with T2DM. [17][18][19] However, the exact causes for an excessive production of asprosin in this condition is uncertain.…”

Section: Discussionsupporting

confidence: 60%

“…24,25 The results of our study supported by many researchers, they found a positive correlation between serum asprosin and BMI in the women with T2DM and poly cystic ovarian syndrome (PCOS). 16,23,26,27 In contrast with these findings, a crosssectional study of Jiang et al revealed that in the PCOS women, serum asprosin was negatively correlated with body mass index. 28 Lipid abnormalities are characteristics and pathological status seen in person with metabolic syndrome and play a great role in the pathogenesis of the disease.…”

Section: Discussionmentioning

confidence: 88%

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Evaluation of serum asprosin levels in women with metabolic syndrome in Duhok City-Kurdistan Region/Iraq

Sulaiman

2021

Int J Res Med Sci

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Background: Serum asprosin, a recently discovered hormone as a new adipocytokine, which has been associated with the regulation of both glucose and lipid metabolism, and insulin resistance. Metabolic syndrome considered as a disorder of lipid and glucose metabolism, with impairment in insulin function, which might be associated with serum asprosin, therefore, new researches focused on the role of asprosin in the pathogenesis of metabolic syndrome to clarify such relationship. This study aimed to evaluate serum asprosin levels in women with metabolic syndrome and compared with a woman without metabolic syndrome.Methods: This study was performed at Obstetrics and Gynecology Hospital, and Mazi medical clinics in Duhok, Kurdistan Region-Iraq, the study was established from June, 2020 to January, 2021. In this cross-sectional study, serum asprosin concertation in 40 women with metabolic syndrome were compared with a 131 women without metabolic syndrome. The demographic data were collected, serum asprosin levels, lipid profile, fasting blood glucose, fasting insulin were biochemically analyzed by using the autoanalyzer machine COBASS series 6000 and ELISA technique.Results: The mean age of women with metabolic syndrome was (24.36±3.23) and women without metabolic syndrome was (23.18±3.87), serum aspersion in women with metabolic syndrome was (18.34±5.4) ng/ml, while in women without metabolic syndrome was (7.48±5.82) with significant difference (p<0.001). In study population, there was a positive correlation between asprosin and body mass index, waist circumference, triglyceride, total cholesterol, fasting blood glucose, fasting insulin, and HOMA-IR (p<0.0001), while serum asprosin was negatively correlated with high density lipoprotein- cholesterol (p<0.01).Conclusions: The study confirms that serum asprosin in women with metabolic syndrome was higher than in the control group.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 88%

Evaluation of serum asprosin levels in women with metabolic syndrome in Duhok City-Kurdistan Region/Iraq

Sulaiman

2021

Int J Res Med Sci

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“…Our findings revealed a relation between elevated serum asprosin concentrations and DN. Another investigation showed that serum asprosin is independently associated with ACR in T2DM population [ 20 ]. Circulating asprosin may be used as a novel serum biomarker for DN evaluation.…”

Section: Discussionmentioning

confidence: 99%

Increased serum asprosin is correlated with diabetic nephropathy

Wang

Lin

Sun

et al. 2021

Diabetol Metab Syndr

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Objective The adipokine asprosin, which was recently discovered, facilitates hepatic glucose production. The aim of this study is to see whether serum asprosin concentrations are linked to diabetic nephropathy (DN). Methods We performed this investigation in a group of 212 type 2 diabetes (T2DM) patients. These patients were classified into three subgroups: DN0 group (normal to mildly increased), DN1 group (moderately increased), and DN2 group (severely increased) on the basis of urine albumin-to-creatinine ratio (ACR). Results When compared to the controls, T2DM patients had higher serum asprosin levels. The DN2 group had significantly higher serum asprosin than the DN0 and DN1 groups. Furthermore, the DN1 group had higher serum asprosin than the DN0 group. Serum asprosin was linked to a higher risk of T2DM and DN in a logistic regression analysis. Serum asprosin was found to be positively related with disease duration, systolic blood pressure, blood urea nitrogen, creatinine, uric acid, ACR, calcium channel blockers, and angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker therapy, but negatively related with glomerular filtration rate, metformin, and acarbose therapy. Conclusion Serum asprosin increase with the progression of DN. Serum asprosin is correlated with renal function and ACR.

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“…Asprosin also impairs muscle cell sensitivity to insulin by promoting inflammation and endoplasmic reticulum (ER) stress, leading to skeletal muscle insulin resistance, which depends on the activation of the PKCδ/SERCA-2 pathway by asprosin [ 30 ]. Moreover, Deng et al [ 31 ] noticed that the level of asprosin independently correlates with the urinary albumin/creatinine ratio, which is considered an index helpful in the detection of early diabetic nephropathy, and in combination with adiponectin level—asprosin could be a marker of early NAFLD diagnosis [ 32 ]. Furthermore, Zhong et al [ 33 ] noted that the level of asprosin increases in pregnant women with gestational diabetes mellitus (GDM) and their newborns, which, as suggested, may be a marker of early GDM diagnosis in this group.…”

Section: Asprosin and Insulin Resistance Diabetes And Obesitymentioning

confidence: 99%

Asprosin—A Fasting-Induced, Glucogenic, and Orexigenic Adipokine as a New Promising Player. Will It Be a New Factor in the Treatment of Obesity, Diabetes, or Infertility? A Review of the Literature

Mazur-Biały

2021

Nutrients

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Asprosin is a recently discovered protein released during fasting conditions mainly by adipocytes from white adipose tissue. As a glucogenic peptide, it stimulates the release of glucose from hepatic cells by binding to the OLFR734 receptor and leading to the activation of the G protein-cAMP-PKA pathway. As it crosses the blood–brain barrier, it also acts as an orexigenic peptide that stimulates food intake through activation of AgRP neurons in the hypothalamus; thus, asprosin participates in maintaining the body’s energy homeostasis. Moreover, studies have shown that asprosin levels are pathologically elevated in obesity and related diseases. However, the administration of anti-asprosin antibodies can both normalize its concentration and reduce food intake in obese mice, which makes it an interesting factor to combat obesity and related diseases. Current research also draws attention to the relationship between asprosin and fertility, especially in men. Asprosin improves age- and obesity-related decrease in fertility potential by improving sperm motility. It should also be mentioned that plasma asprosin levels can be differentially modulated by physical activity; intense anaerobic exercise increases asprosin level, while aerobic exercise decreases it. However, further research is necessary to confirm the exact mechanisms of asprosin activity and its potential as a therapeutic target.

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<p>Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes</p>

Cited by 21 publications

References 36 publications

Evaluation of serum asprosin levels in women with metabolic syndrome in Duhok City-Kurdistan Region/Iraq

Evaluation of serum asprosin levels in women with metabolic syndrome in Duhok City-Kurdistan Region/Iraq

Increased serum asprosin is correlated with diabetic nephropathy

Asprosin—A Fasting-Induced, Glucogenic, and Orexigenic Adipokine as a New Promising Player. Will It Be a New Factor in the Treatment of Obesity, Diabetes, or Infertility? A Review of the Literature

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