&lt;p&gt;Long Non-Coding RNA USP2-AS1 Accelerates Cell Proliferation and Migration in Ovarian Cancer by Sponging miR-520d-3p and Up-Regulating KIAA1522&lt;/p&gt;

Guo, Bin; Yu, Lan; Sun, Yanhong; Yao, Nan; Ma, Li

doi:10.2147/cmar.s268863

Cited by 14 publications

(11 citation statements)

References 24 publications

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“…These results indicate that MAP3K3 mediates the effect of lncRNA CTBP1-DT in regulating the malignant biological behaviour of HGSOC cells in vivo. Previous studies have confirmed that lncRNA USP2-AS1 [ 28 ], HOXD-AS1 [ 29 ] and HEIH [ 24 ] are upregulated in OC, which can, in effect, promote the progression and development of OC cells by upregulating the expression of downstream target genes. LncRNA CTBP1-DT has been shown to elevate ZNF217 expression in cervical cancer [ 14 ] and regulate phosphatase and tensin homologue to suppress OC cell proliferation [ 30 ].…”

Section: Discussionmentioning

confidence: 95%

ETV5-mediated upregulation of lncRNA CTBP1-DT as a ceRNA facilitates HGSOC progression by regulating miR-188-5p/MAP3K3 axis

Liu

Chen

et al. 2021

Cell Death Dis

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High-grade serous ovarian cancer (HGSOC) is a common and lethal cancer of the female reproductive system. Long non-coding RNAs (lncRNAs) are aberrantly expressed in various cancers and play crucial roles in tumour progression. However, their function and molecular mechanism in HGSOC remain largely unknown. Based on public databases and bioinformatics analyses, the overexpression of lncRNA CTBP1-DT in HGSOC tissues was detected and validated in a cohort of HGSOC tissues. High expression of lncRNA CTBP1-DT was associated with poor prognosis and was an independent risk factor for survival. Overexpression of lncRNA CTBP1-DT promoted malignant biological behaviour of HGSOC cells, whereas its depletion induced growth arrest of HGSOC cells by vitro and in vivo assays. Mechanistically, lncRNA CTBP1-DT could competitively bind to miR-188-5p to protect MAP3K3 from degradation. Moreover, our results revealed that ETV5 could specifically interact with the promoter of lncRNA CTBP1-DT and activate its transcription. Collectively, these results reveal a novel ETV5/lncRNA CTBP1-DT/miR-188-5p/MAP3K3 pathway for HGSOC progression and suggest that lncRNA CTBP1-DT might be a potential biomarker and therapeutic target for HGSOC.

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Section: Discussionmentioning

confidence: 95%

ETV5-mediated upregulation of lncRNA CTBP1-DT as a ceRNA facilitates HGSOC progression by regulating miR-188-5p/MAP3K3 axis

Liu

Chen

et al. 2021

Cell Death Dis

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“…Among these biomarkers, only MKLN1-AS has been reported in HCC and is considered a diagnostic and prognostic biomarker (42). HPN-AS1 could be utilized in the diagnosis of prostate cancer (43); LINC00607 facilitates the proliferation and invasion of osteosarcoma (44); USP2-AS1 promotes the progression of colon cancer and ovarian cancer (45,46); and LINC00638 and LINC00652 have been reported in nontumor diseases (47)(48)(49)(50), while no study has revealed the function of the remaining lncRNAs. As a result, further exploration of these lncRNAs may improve insight into the molecules underlying HCC.…”

Section: Discussionmentioning

confidence: 99%

Tumor Mutation Burden-Associated LINC00638/miR-4732-3p/ULBP1 Axis Promotes Immune Escape via PD-L1 in Hepatocellular Carcinoma

Feng

Zhao

et al. 2021

Front. Oncol.

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Tumor mutation burden (TMB) is associated with immune infiltration, while its underlying mechanism in hepatocellular carcinoma (HCC) remains unclear. A long noncoding RNA (lncRNA)-related competitive endogenous RNA (ceRNA) network can regulate various tumor behaviors, and research about its correlation with TMB and immune infiltration is warranted. Data were downloaded from TCGA and ArrayExpress databases. Cox analysis and machine learning algorithms were employed to establish a lncRNA-based prognostic model for HCC. We then developed a nomogram model to predict overall survival and odds of death for HCC patients. The association of this prognostic model with TMB and immune infiltration was also analyzed. In addition, a ceRNA network was constructed by using DIANA-LncBasev2 and the starBase database and verified by luciferase reporter and colocalization analysis. Multiplex immunofluorescence was applied to determine the correlation between ULBP1 and PD-L1. An eight-lncRNA (SLC25A30-AS1, HPN-AS1, LINC00607, USP2-AS1, HCG20, LINC00638, MKLN1-AS and LINC00652) prognostic score model was constructed for HCC, which was highly associated with TMB and immune infiltration. Next, we constructed a ceRNA network, LINC00638/miR-4732-3p/ULBP1, that may be responsible for NK cell infiltration in HCC with high TMB. However, patients with high ULBP1 possessed a poorer prognosis. Using multiplex immunofluorescence, we found a significant correlation between ULBP1 and PD-L1 in HCC, and patients with high ULBP1 and PD-L1 had the worst prognosis. In brief, the eight-lncRNA model is a reliable tool to predict the prognosis of HCC patients. The LINC00638/miR-4732-3p/ULBP1 axis may regulate immune escape via PD-L1 in HCC with high TMB.

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“…USP2-AS1 was observed to be a direct target of HIF1-α, and it is overexpressed in HNSCC, promoting cell proliferation and invasion through regulating DCAF13 activity ( 125 ). Additionally, USP2-AS1 was observed to be upregulated in ovarian cancer ( 126 ). It is a direct target of the transcription factor Myc, a key oncogene, promoting tumor progression through the regulation of E2F1 expression ( 127 ).…”

Section: Resultsmentioning

confidence: 99%

lncHUB2: aggregated and inferred knowledge about human and mouse lncRNAs

et al. 2023

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Long non-coding ribonucleic acids (lncRNAs) account for the largest group of non-coding RNAs. However, knowledge about their function and regulation is limited. lncHUB2 is a web server database that provides known and inferred knowledge about the function of 18 705 human and 11 274 mouse lncRNAs. lncHUB2 produces reports that contain the secondary structure fold of the lncRNA, related publications, the most correlated coding genes, the most correlated lncRNAs, a network that visualizes the most correlated genes, predicted mouse phenotypes, predicted membership in biological processes and pathways, predicted upstream transcription factor regulators, and predicted disease associations. In addition, the reports include subcellular localization information; expression across tissues, cell types, and cell lines, and predicted small molecules and CRISPR knockout (CRISPR-KO) genes prioritized based on their likelihood to up- or downregulate the expression of the lncRNA. Overall, lncHUB2 is a database with rich information about human and mouse lncRNAs and as such it can facilitate hypothesis generation for many future studies. The lncHUB2 database is available at https://maayanlab.cloud/lncHUB2. Database URL: https://maayanlab.cloud/lncHUB2

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<p>Long Non-Coding RNA USP2-AS1 Accelerates Cell Proliferation and Migration in Ovarian Cancer by Sponging miR-520d-3p and Up-Regulating KIAA1522</p>

Cited by 14 publications

References 24 publications

ETV5-mediated upregulation of lncRNA CTBP1-DT as a ceRNA facilitates HGSOC progression by regulating miR-188-5p/MAP3K3 axis

ETV5-mediated upregulation of lncRNA CTBP1-DT as a ceRNA facilitates HGSOC progression by regulating miR-188-5p/MAP3K3 axis

Tumor Mutation Burden-Associated LINC00638/miR-4732-3p/ULBP1 Axis Promotes Immune Escape via PD-L1 in Hepatocellular Carcinoma

lncHUB2: aggregated and inferred knowledge about human and mouse lncRNAs

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