&lt;p&gt;The association between omentin and diabetes: a systematic review and meta-analysis of observational studies&lt;/p&gt;

́habi, Atefeh As; Sadeghi, Malihe; Arab, Arman; Hajianfar, Hossein

doi:10.2147/dmso.s206981

Cited by 27 publications

(17 citation statements)

References 62 publications

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“…In vitro and animal studies have shown that omentin enhances insulin action in human adipocytes and has beneficial effects on cardiovascular system [8,9]. Majority of the studies have shown that circulating levels of omentin are decreased in individuals with obesity and T2D [10][11][12][13] and positively associated with flow-mediated vasodilatation [14,15] suggesting a protective role of human omentin on cardiometabolic health. Even though omentin and adiponectin have been shown to have anti-inflammatory and cardioprotective effects, only a few studies have examined the physiological link between these adipokines in relation to cardiometabolic diseases [16,17].…”

Section: Introductionmentioning

confidence: 99%

Circulating adiponectin mediates the association between omentin gene polymorphism and cardiometabolic health in Asian Indians

et al. 2021

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Background Plasma omentin levels have been shown to be associated with circulating adiponectin concentrations and cardiometabolic disease-related outcomes. In this study, we aim to examine the association of omentin gene polymorphism with serum adiponectin levels and cardiometabolic health status using a genetic approach, and investigate whether these associations are modified by lifestyle factors. Methods The study included 945 normal glucose tolerant and 941 unrelated individuals with type 2 diabetes randomly selected from the Chennai Urban Rural Epidemiology Study (CURES), in southern India. Study participants were classified into cardiometabolically healthy and unhealthy, where cardiometabolically healthy were those without hypertension, diabetes, and dyslipidemia. Fasting serum adiponectin levels were measured by radioimmunoassay. The omentin A326T (rs2274907) single nucleotide polymorphism (SNP) was screened by polymerase chain reaction-restriction fragment length polymorphism and direct sequencing. Results The ‘A’ allele of the omentin SNP was significantly associated with lower adiponectin concentrations after adjusting for age, sex, body mass index (BMI), waist circumference (WC) and cardiometabolic health status (p = 1.90 x 10−47). There was also a significant association between circulating adiponectin concentrations and cardiometabolic health status after adjusting for age, sex, BMI, WC and Omentin SNP (p = 7.47x10-10). However, after adjusting for age, sex, BMI, WC and adiponectin levels, the association of ‘A’ allele with cardiometabolic health status disappeared (p = 0.79) suggesting that adiponectin serves as a mediator of the association between omentin SNP and cardiometabolic health status. There were no significant interactions between the SNP and dietary factors on adiponectin levels and cardiometabolic health status (p>0.25, for all comparisons). Conclusions Our findings show that adiponectin might function as a mechanistic link between omentin SNP and increased risk of cardiometabolic diseases independent of common and central obesity in Asian Indians. Before strategies to promote adiponectin modulation could be implemented, further studies are required to confirm the molecular mechanisms involved in this triangular relationship between omentin gene, adiponectin and cardiometabolic diseases.

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Section: Introductionmentioning

confidence: 99%

Circulating adiponectin mediates the association between omentin gene polymorphism and cardiometabolic health in Asian Indians

et al. 2021

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“…Second, the GDM subgroup which was not included in the previous meta-analysis was included in this study and yielded significant results. Finally, unlike in the previous meta-analysis, this study further elaborated on the omentin-1 possible mechanism in the pathophysiology of diabetes [14].…”

Section: Discussionmentioning

confidence: 99%

“…Although a previous meta-analysis analyzed the relationship between concentrations ometin-1 and diabetes mellitus, that study focused only on T1DM and T2DM, and included only 28 articles. Therefore, it was necessary to conduct a more comprehensive systematic review and meta-analysis of this relationship [14]. Accordingly, the aim of this study was to use systematic review and meta-analysis methods to synthesize research results related to the association between omentin-1 concentrations and DM, and to measure the significance of this association.…”

Section: Introductionmentioning

confidence: 99%

Omentin-1 in diabetes mellitus: A systematic review and meta-analysis

et al. 2019

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ObjectivePrevious studies found inconsistent results on the relationship between diabetes mellitus and concentrations of omentin-1. This study performed a systematic review and meta-analysis to summarize previous findings on this relationship.MethodsStudies related to this outcome were obtained using a systematic search in the electronic databases of Cochrane Library, PubMed, Embase, SCOPUS, Google Scholar, gray literature and Web of Science in September 2019. The random effects model was used to measure the strength of the association between diabetes mellitus and concentrations of omentin-1, using standardized mean difference.ResultsForty-two eligible studies were included in the final meta-analysis. There was no significant difference in omentin-1 concentration between patients with type 1 diabetes mellitus and the controls. On the other hand, lower concentration levels of omentin-1 were observed in patients with gestational diabetes mellitus (standardized mean difference:-0.44, 95% confidence interval:-0.76; -0.12, p = 0.007), or type 2 diabetes mellitus (standardized mean difference: -1.74, 95% confidence interval: -2.31; -1.16, p< 0.001) than in the controls.ConclusionDecreased omentin-1 concentrations may be an important indicator for gestational diabetes mellitus and type 2 diabetes mellitus. More studies are needed to validate this hypothesis and evaluate the role of omentin-1 concentrations in type 1 diabetes mellitus.

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“…In vitro and animal studies have shown that omentin enhances insulin action in human adipocytes and has beneficial effects on cardiovascular system [8, 9]. Majority of the studies have shown that circulating levels of omentin are decreased in individuals with obesity and T2D [10–13] and positively associated with flow-mediated vasodilatation [14, 15] suggesting a protective role of human omentin on cardiometabolic health. Even though omentin and adiponectin have been shown to have anti-inflammatory and cardioprotective effects, only a few studies have examined the physiological link between these adipokines in relation to cardiometabolic diseases [16, 17].…”

Section: Introductionmentioning

confidence: 99%

Circulating adiponectin mediates the association between omentin gene polymorphism and cardiometabolic health in Asian Indians

Vimaleswaran

Jiang

Dhanasekaran

et al. 2020

Preprint

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Background : Plasma omentin levels have been shown to be associated with circulating adiponectin concentrations and cardiometabolic disease-related outcomes. However, the findings have been inconsistent due to high level of confounding. In this study, we aim to examine the association of omentin gene polymorphism with plasma adiponectin levels and cardiometabolic health status using a genetic approach, which is less prone to confounding, and investigate whether these associations are modified by lifestyle factors such as diet and physical activity. Methods : The study included 945 normal glucose tolerant and 941 unrelated individuals with type 2 diabetes randomly selected from the Chennai Urban Rural Epidemiology Study (CURES), in southern India. Study participants were further classified into cardiometabolically healthy and unhealthy, where cardiometabolically healthy were those without hypertension, diabetes, and dyslipidemia. Fasting serum adiponectin levels were measured by radioimmunoassay. The A326T (rs2274907) single nucleotide polymorphism (SNP) in the exon 4 of the omentin gene was screened by polymerase chain reaction-restriction fragment length polymorphism and direct sequencing. Results : The ‘A’ allele of the omentin SNP was significantly associated with lower adiponectin concentrations after adjusting for age, sex, body mass index (BMI), waist circumference (WC) and cardiometabolic health status (p=1.90 x 10 -47 ). There was also a significant association between circulating adiponectin concentrations and cardiometabolic health status after adjusting for age, sex, BMI, WC and Omentin SNP (p=7.47x10 -10 ). However, after adjusting for age, sex, BMI, WC and adiponectin levels, the association of ‘A’ allele with cardiometabolic health status disappeared (p=0.79) suggesting that adiponectin serves as a mediator of the association between omentin SNP and cardiometabolic health status. There were no significant interactions between the SNP and dietary factors on adiponectin levels and cardiometabolic health status (p>0.25, for all comparisons). Conclusions : Our findings show that adiponectin might function as a mechanistic link between omentin SNP and increased risk of cardiometabolic diseases independent of common and central obesity in this Asian Indian population. Further studies are required to confirm the molecular mechanisms involved in this triangular relationship between omentin gene, adiponectin and cardiometabolic diseases.

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<p>The association between omentin and diabetes: a systematic review and meta-analysis of observational studies</p>

Cited by 27 publications

References 62 publications

Circulating adiponectin mediates the association between omentin gene polymorphism and cardiometabolic health in Asian Indians

Circulating adiponectin mediates the association between omentin gene polymorphism and cardiometabolic health in Asian Indians

Omentin-1 in diabetes mellitus: A systematic review and meta-analysis

Circulating adiponectin mediates the association between omentin gene polymorphism and cardiometabolic health in Asian Indians

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