&lt;title&gt;Multifrequency YAG:Nd laser for diagnosis of malignant tumors&lt;/title&gt;

Introduction: The laser-induced fluorescence (LIF) method as molecular emission spectroscopy is used to diagnose cancerous tissues. According to the previous reports, the red-shift in the fluorescence spectrum from Rhodamine 6G (Rd6G)-stained cancerous tissues compared to healthy ones impregnated with the same dye provides the feasibility for diagnosis. In this paper, we have employed the LIF emissions as a diagnostic method to distinguish between cancerous and healthy tissues infiltrated by a body-compatible fluorophore to avoid the toxicity and hazard of Rd6G dye. Methods: Biological tissue specimens are stained with sodium fluorescein (NaFl) dye and then irradiated by the blue CW diode laser (405 nm) to examine the spectral properties that are effective in detecting cancerous tissues. Results: The spectral shift and the intensity difference of fluorescence are keys to diagnosing in vitro cancerous breast, colon, and thyroid tissues for clinical applications. The notable tubular densities in the breast and colon tissues and the space between the papillae in the thyroid ones cause the cancerous tissues to be prominently heterogeneous, providing numerous micro-cavities and thus more room for dye molecules. Conclusion: Here, we have assessed the spectral shift and intensity difference of fluorescence as a diagnostic method to distinguish between cancerous and healthy tissues for clinical applications.

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“…For the fluorescence diagnosis of human malignancy, NaFl is permitted and recommended for its high specificity to the tumor. 11…”

Section: Introductionmentioning

confidence: 99%

Cancerous Tissue Diagnosis by LIF Spectroscopy Derived From Body-Compatible Fluorophores

et al. 2021

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Spectral changes of lung cancer serum in the process of tumor evolution

He²,

Jin³

2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Raman spectroscopy and fluorescence for the detection of liver cancer and abnormal liver tissue

Lin²,

Ding³

et al.

The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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In this paper, laser induced human serum Raman spectra of liver cancer are measured. The spectra in serum differences between normal people and liver cancer patients are analyzed. For the typical spectrum of normal serum, there are three sharp Raman peaks and relative intensity of Raman peaks excited by 514.5 nm is higher than that excited by 488.0 nm. However, for the Raman spectrum of liver cancer serum there are no peaks or very weak Raman peaks at the same positions. To liver cirrhosis, the shape of Raman peak is similar to normal and fluorescence spectrum is similar to that of liver cancer from statistic data. The results from more than two hundred case measurements show that the spectral diagnosis was in good agreement with the clinical result. Moreover, the liver fibrosis and liver cirrhosis were studied using the technology of LIF. The experiment indicates that the blue shift of fluorescence peak difference between the normal, liver fibrosis and liver cirrhosis were observed. These results have important reference values to explore the method of laser spectrum diagnosis.

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<title>Multifrequency YAG:Nd laser for diagnosis of malignant tumors</title>

Cited by 5 publications

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Cancerous Tissue Diagnosis by LIF Spectroscopy Derived From Body-Compatible Fluorophores

Cancerous Tissue Diagnosis by LIF Spectroscopy Derived From Body-Compatible Fluorophores

Spectral changes of lung cancer serum in the process of tumor evolution

Raman spectroscopy and fluorescence for the detection of liver cancer and abnormal liver tissue

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