Lucentamycins A−D, Cytotoxic Peptides from the Marine-Derived Actinomycete Nocardiopsis lucentensis

Cho, Ji Young; Williams, Philip G.; Kwon, Hak Chol; Jensen, Paul R.; Fenical, William

doi:10.1021/np070101b

Cited by 109 publications

(80 citation statements)

References 14 publications

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“…39 Many of them display interesting bioactivities such as FKBP12 binding activity, 26 apoptosis, 29 cytotoxicity, 31,33,37 macrophage activating properties, 34 and an inhibitory effect on TNF-α-induced NFκB activation. 39 However, little is known about the secondary metabolites of halophilic actinomycetes.…”

Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

Isolation and Characterization of New p-Terphenyls with Antifungal, Antibacterial, and Antioxidant Activities from Halophilic Actinomycete Nocardiopsis gilva YIM 90087

Tian

Xiang

Luo

et al. 2013

J. Agric. Food Chem.

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A new p-terphenyl 1 and a novel p-terphenyl derivative 3 bearing a benzothiazole moiety were isolated from halophilic actinomycete Nocardiopsis gilva YIM 90087, along with known p-terphenyl 2, antibiotic novobiocin 4, cyclodipeptides 5−13, and aromatic acids 14 and 15. Their structures were elucidated on the basis of the interpretation of spectral data and by comparison of the corresponding data with those reported previously. The p-terphenyl 1 showed antifungal activity against the three pathogenic fungi, including Fusarium avenaceum, Fusarium graminearum, and Fusarium culmorum, that caused Fusarium head blight with minimal inhibitory concentrations (MICs) of 8, 16, and 128 μg/mL, respectively. Compound 1 showed antifungal activity against Candida albicans with a MIC of 32 μg/mL and antibacterial activity against Bacillus subtilis with a MIC of 64 μg/mL. Novobiocin 4 showed antifungal activity against Pyricularia oryzae with a MIC of 16 μg/mL and antibacterial activity against B. subtilis with a MIC of 16 μg/mL and Staphylococcus aureus with a MIC of 64 μg/mL. The 1,1-diphenyl-2-picrylhydrazyl assay suggested that 1, 3, and 4 exhibited 54.9% (2 mg/mL), 14.3% (4 mg/mL), and 47.7% (2 mg/mL) free radical scavenging activity, respectively. The positively charged 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid radical (ABTS +• ) scavenging assay indicated that 1, 3, 4, and 8 exhibited 68.6% (1 mg/mL), 28.4% (2 mg/mL), 78.2% (0.5 mg/mL), and 54.6% (2 mg/mL) ABTS +• scavenging capacity, respectively. The superoxide anion radical scavenging assay suggested that 4 exhibited 77.9% superoxide anion radical scavenging capacity at 2 mg/mL. N. gilva YIM 90087 is a new resource for novobiocin 4.

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Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

Isolation and Characterization of New p-Terphenyls with Antifungal, Antibacterial, and Antioxidant Activities from Halophilic Actinomycete Nocardiopsis gilva YIM 90087

Tian

Xiang

Luo

et al. 2013

J. Agric. Food Chem.

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“…Biological metabolites isolated from marine actinomycetes, particularly the genus Streptomyces, have a relatively low productivity of <1 mg/L of culture; 18,19,[37][38][39][40] for example, Streptomyces sp. CNB-982 produces 0.1 mg/L of anti-inflammatory cyclomarin, 37) and Streptomyces sp.…”

Section: Discussionmentioning

confidence: 99%

Isolation and Structural Determination of the Antifouling Diketopiperazines from Marine-Derived Streptomyces praecox 291-11

Cho¹,

Kang

Hong

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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“…Dermacoccus abyssi, actinomycete strains isolated from the Mariana Trench sediment, produces phenazine-type secondary metabolites (dermacozines (16)) that possess antitumour (against Marinomycin A, daryamide C, lucentamycins (A,B), mansouramycins (13) and tatrolons (Figure 8) are other antitumour compounds that have been obtained from actinomycete strains found in marine sediments [11]. In 2007 Cho et al [74] isolated novel compounds, lucentamycins A-D. Their chemical structure includes 3-methyl-4-ethylideneproline-containing peptides. They were isolated from marine Nocardiopsis lucentensis (strain CNR-712).…”

Section: Anticancer Activity Of Actinomycete Metabolites Now and In mentioning

confidence: 99%

“…They were isolated from marine Nocardiopsis lucentensis (strain CNR-712). Lucentamycin A and B show potent activity against HCT-116 human colon carcinoma cells [11,74]. Mansouramycins A-D are isoquinolinequinones isolated from the marine-derived Mei37 isolate of Streptomyces sp.…”

Section: Anticancer Activity Of Actinomycete Metabolites Now and In mentioning

confidence: 99%

Biologically active secondary metabolites from Actinomycetes

Solecka¹,

Zajko²,

Postek³

et al. 2012

Open Life Sciences

113

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AbstractSecondary metabolites obtained from Actinomycetales provide a potential source of many novel compounds with antibacterial, antitumour, antifungal, antiviral, antiparasitic and other properties. The majority of these compounds are widely used as medicines for combating multidrug-resistant Gram-positive and Gram-negative bacterial strains. Members of the genus Streptomyces are profile producers of previously-known secondary metabolites. Actinomycetes have been isolated from terrestrial soils, from the rhizospheres of plant roots, and recently from marine sediments. This review demonstrates the diversity of secondary metabolites produced by actinomycete strains with respect to their chemical structure, biological activity and origin. On the basis of this diversity, this review concludes that the discovery of new bioactive compounds will continue to pose a great challenge for scientists.

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Lucentamycins A−D, Cytotoxic Peptides from the Marine-Derived Actinomycete Nocardiopsis lucentensis

Cited by 109 publications

References 14 publications

Isolation and Characterization of New p-Terphenyls with Antifungal, Antibacterial, and Antioxidant Activities from Halophilic Actinomycete Nocardiopsis gilva YIM 90087

Isolation and Characterization of New p-Terphenyls with Antifungal, Antibacterial, and Antioxidant Activities from Halophilic Actinomycete Nocardiopsis gilva YIM 90087

Isolation and Structural Determination of the Antifouling Diketopiperazines from Marine-Derived <i>Streptomyces praecox</i> 291-11

Biologically active secondary metabolites from Actinomycetes

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