Luminescence-Based Sensors for Bioprocess Applications

Urriza-Arsuaga, Idoia; Ielasi, Guido; Bedoya, Maximino; Orellana, Guillermo

doi:10.1007/4243_2019_10

Cited by 4 publications

(4 citation statements)

References 146 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Commercially available luminescent and fluorescent sensors comprised the dye indicator matrix and fiber optics connected to the spectrometer. By immobilizing a pH‐sensitive luminophore in a polymer matrix, spectrum, intensity, or luminescence lifetime changes can occur through reversible protonation or deprotonation [74] . There are commercial products following this format, like DOTS (SBI GmbH) and SP‐HP5‐SA (PreSens) (Figure 4e).…”

Section: Cellular Environmentmentioning

confidence: 99%

“…Additionally, it cannot be sterilized and is susceptible to biofouling and protein contamination, necessitating regular maintenance. [74] Furthermore, there are optical sensing systems based on the pH-responsive luminescent dye molecules that the spectrometer can detect. There is a notable contrast between optical and electrochemical sensors regarding measuring techniques.…”

Section: Ph Monitoringmentioning

confidence: 99%

“…By immobilizing a pH-sensitive luminophore in a polymer matrix, spectrum, intensity, or luminescence lifetime changes can occur through reversible protonation or deprotonation. [74] There are commercial products following this format, like DOTS (SBI GmbH) and SP-HP5-SA (PreSens) (Figure 4e).…”

Section: Ph Monitoringmentioning

confidence: 99%

See 2 more Smart Citations

Advances in sensor developments for cell culture monitoring

Kim,

Yeo

2023

BMEMat

View full text Add to dashboard Cite

Cell culture encompasses procedures for extracting cells from their natural tissue and cultivating them under controlled artificial conditions. During this process, various factors, including cell physiological/morphological properties, culture environments, metabolites, and contaminants, have to be precisely controlled and monitored for the survival of cells and the pursuit of the desired properties of the cells. This review summarizes recent advances in sensor technologies and manufacturing strategies for various cell culture platforms using traditional plastics, microfluidic chips, and scalable bioreactors. We share the details of newly developed biological sensors, chemical sensors, optical sensors, electronic chip technologies, and material integration methods. The precise control of parameters based on the feedback by these sensors and electronics enhances cell culture quality and throughput.

show abstract

Section: Cellular Environmentmentioning

confidence: 99%

Section: Ph Monitoringmentioning

confidence: 99%

See 1 more Smart Citation

Advances in sensor developments for cell culture monitoring

Kim,

Yeo

2023

BMEMat

View full text Add to dashboard Cite

show abstract

“…Among all the chemosensing platforms, luminescence-based sensors have been widely used for environmental monitoring, food safety assurance, and process analysis due to their high sensitivity, good selectivity, ease of miniaturization, and robustness, if luminescence lifetime rather than intensity measurements are carried out. , In this regard, luminescent ruthenium(II) polypyridyl complexes are particularly suitable for chemical sensing due to their large Stokes shift (>150 nm), good thermal and photochemical stability, and their relatively long-lived excited state (up to 7 μs) . Furthermore, their (photo)chemical and (photo)physical properties may be finely tuned by a judicious selection of the polyazaheterocyclic chelating ligands around the metal core.…”

Section: Introductionmentioning

confidence: 99%

Interaction of a 1,3-Dicarbonyl Toxin with Ru(II)-Biimidazole Complexes for Luminescence Sensing: A Spectroscopic and Photochemical Experimental Study Rationalized by Time-Dependent Density Functional Theory Calculations

et al. 2021

Self Cite

View full text Add to dashboard Cite

A family of ruthenium(II) complexes containing one 2,2′-biimidazole (bim) ligand and two polypyridyl (NN) ligands has been prepared and their photophysical and photochemical features have been tested in the presence of tenuazonic acid (TeA), a widespread food and feed mycotoxin of current concern. While not tested in in vivo studies, TeA and other secondary metabolites of Alternaria fungi are suspected to exert adverse effects on the human health, so sensors and rapid analytical procedures are required. It is well-known that 1,3-dicarbonyl compounds such as TeA are relatively easy to deprotonate (the p K a of TeA is 3.5), yielding an enolate anion stabilized by resonance. The chelating and hydrogen-donor features of bim allow simultaneous binding to the metal core and to the target β-diketonate delocalized anion. Such a binding induces changes in the blue absorption (40 nm bathochromic shift), red luminescence intensity (>75% quenching), and triplet lifetime (0.2 μs decrease) of the Ru(NN) 2 (bim) 2+ luminophore. Moreover, we have computationally rationalized, by time-dependent density functional theory, the structure of the different adducts of Ru–bim complexes with TeA and the electronic nature of the spectral absorption bands and their change upon the addition of TeA.

show abstract

Advanced multimodal solid-state optochemical pH and dual pH/O2 sensors for cell analysis

Li¹,

Zhdanov²

2022

Sensors and Actuators B: Chemical

View full text Add to dashboard Cite

Luminescence-Based Sensors for Bioprocess Applications

Cited by 4 publications

References 146 publications

Advances in sensor developments for cell culture monitoring

Advances in sensor developments for cell culture monitoring

Interaction of a 1,3-Dicarbonyl Toxin with Ru(II)-Biimidazole Complexes for Luminescence Sensing: A Spectroscopic and Photochemical Experimental Study Rationalized by Time-Dependent Density Functional Theory Calculations

Advanced multimodal solid-state optochemical pH and dual pH/O2 sensors for cell analysis

Contact Info

Product

Resources

About