Lung alveoli array-on-chip with a bioartificial membrane

Zamprogno, Pauline; Achenbach, Sven; Stucki, Janick; Hobi, Nina; Schneider-Daum, Nicole; Lehr, Claus‐Michael; Huwer, Hanno; Schmid, Ralph A.; Guénat, O.

doi:10.1016/j.toxlet.2017.07.974

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“…Microfluidic chips are extensively applied in in-vitro biomedical models because of their flexibility, such as having control over fluid and gas flow, and a chip architecture able to replace the classical 2D and 3D cell cultures [1]. Many organ models were established in recent years, based on the microfluidic platform, such as brain-on-a-chip, liver-on-a-chip, lung-on-a-chip, and breast-on-a-chip [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Body-on-a-chip is designed to include more than one organ on one chip [20].…”

Section: Introductionmentioning

confidence: 99%

The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review

Song

et al. 2020

Micromachines

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Microfluidic systems have been widely explored based on microfluidic technology, and it has been widely used for biomedical screening. The key parts are the fabrication of the base scaffold, the construction of the matrix environment in the 3D system, and the application mechanism. In recent years, a variety of new materials have emerged, meanwhile, some new technologies have been developed. In this review, we highlight the properties of high throughput and the biomedical application of the microfluidic chip and focus on the recent progress of the fabrication and application mechanism. The emergence of various biocompatible materials has provided more available raw materials for microfluidic chips. The material is not confined to polydimethylsiloxane (PDMS) and the extracellular microenvironment is not limited by a natural matrix. The mechanism is also developed in diverse ways, including its special physical structure and external field effects, such as dielectrophoresis, magnetophoresis, and acoustophoresis. Furthermore, the cell/organ-based microfluidic system provides a new platform for drug screening due to imitating the anatomic and physiologic properties in vivo. Although microfluidic technology is currently mostly in the laboratory stage, it has great potential for commercial applications in the future.

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Section: Introductionmentioning

confidence: 99%

The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review

Song

et al. 2020

Micromachines

View full text Add to dashboard Cite

show abstract

Lung alveoli array-on-chip with a bioartificial membrane

Cited by 1 publication

References 0 publications

The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review

The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review

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