Lung Cancer and Chronic Interstitial Pneumonia Associated With Systemic Sarcoidosis

Abstract

Lung cancer and chronic interstitial pneumonia associated with systemic sarcoidosis was detected in a 66-year-old woman at autopsy. Histologically, hyalinized sarcoid lesions were scattered in cervical lymph nodes, thoracic lymph nodes, abdominal lymph nodes, and spleen. Scattered non-caseating epithelioid cell granulomas with giant cells were observed in both lungs remoting cancer and chronic interstitial pneumonia. A tumor mass occupying right hilar portion was well-differentiated squamous cell carcimona involving right upper lobe and right hilar lymph nodes. In the lower lobe of the left lung, a small nodule of poorly differentiated squamous cell carcinoma was detected. Alveolar septa, especially in both lower lobes of the lungs were thickened diffusely with fibrosis, edema, and inflammatory cell infiltration. Alveolar cavities contained hyaline membrane and large mononuclear cells. Atypical bronchiolar epithelial proliferation and squamous metaplasia associated with squamous cell carcinoma were detected. The clinical and pathological characteristics among eight reported cases of lung cancer associated with sarcoidosis and three reported cases of interstitial pneumonia associated with sarcoidosis were reviewed separately. There is no report describing both lung cancer and chronic interstitial pneumonia associated with sarcoidosis. ACTA PATHOL.

Endobronchial ultrasound-guided transbronchial needle aspiration facilitating diagnosis of sarcoidosis in a breast cancer patient with multiple lymphadenopathy: a case report

“…Some authors have suggested the following relationship between malignant tumors and sarcoid reactions: (1) a localized defense reaction to tumor cells themselves, (2) a simple tissue reaction to tumor embolism into the lymphatic system or capillaries, or (3) an immunological reaction to substances released from tumors transported along the lymphatic system [ 24 , 25 ]. Diagnose of sarcoidosis requires confirmation of epithelioid granulomas in tissues that are not close to malignant tumors and consideration of other systemic symptoms and laboratory findings [ 26 ].…”

Μελέτη Της Αστάθειας Μικροδορυφορικού DNA Σε Κυτταρολογικά Δείγματα Ασθενών Με Διάμεση Διηθητική Πνευμονοπάθεια

“…ΜΑ έχουν ανιχνευθεί σε όλους σχεδόν τους ανθρώπινους όγκους[233][234][235]257,259,273,[279][280][281][282][283][284][285][286][287][288] καθώς και σε καλοήθεις διαταραχές, όπως στην αθηροσκλήρυνση[248][249][250] και στο πτερύγιο του οφθαλμού251,252 , γεγονός που υποδηλώνει ότι αυτές οι ασθένειες έχουν παρόμοιο μηχανισμό με τις νεοπλασίες και ίσως θα μπορούσαν να θεωρηθούν ως καλοήθεις νεοπλασματικές καταστάσεις. Η σαρκοείδωση, θεωρείται καλοήθης βλάβη, παρά ταύτα υπάρχουν δεδομένα που δηλώνουν αυξημένη προδιάθεση σε αυτούς τους ασθενείς για ανάπτυξη καρκίνου του πνεύμονα[70][71][72][73][74][75][76][77][78][79][80] , όσο και άλλων συστημάτων[81][82][83] . (Εδώ πάντως θα πρέπει να σχολιαστεί ότι η παρατήρηση αυτή έχει και τον αντίλογό της84,85 ).Η επαναλαμβανόμενη μονάδα όλων των δεικτών μικροδορυφορικού DNA που χρησιμοποιήσαμε σ' αυτή τη μελέτη είναι ένα δινουκλεοτίδιο.…”