Lung Cancer in Young Adults

Bourke, W.; Milstein, David; Giura, R; Donghi, M; Luisetti, Maurizio; Rubin, Ami‐Hai E.; Smith, Lewis J.

doi:10.1378/chest.102.6.1723

Cited by 96 publications

(92 citation statements)

References 22 publications

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“…Lung cancer in young adults has several unique characteristics: a high percentage of patients are female, more adenocarcinoma, and more advanced stage at the time of diagnosis, and more patients receiving aggressive treatment [8][9][10][11]. Previous studies have shown that young patients had a similar survival as older patients [12].…”

Section: Discussionmentioning

confidence: 99%

Metastatic Adenocarcinoma in the Young Adult

Mehta¹,

Jain²,

Desai³

et al. 2017

Arch Surg Oncol

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We report a case of metastatic adenocarcinoma pleura in a non-smoking 29-year-old man. X-ray Chest revealed Left sided repeated pleural effusion despite repeated tapping. CT revealed a moderate Left sided pleural effusion. A VATS biopsy of the Left Pleural Nodules and Left lung nodules revealed a metastatic adenocarcinoma. He was a non-smoker and molecular markers revealed an EGFR Mutation and were started on oral TKI. He had near complete resolution after 6 months except for mild thickening of the pleura at the base.

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Section: Discussionmentioning

confidence: 99%

Metastatic Adenocarcinoma in the Young Adult

Mehta¹,

Jain²,

Desai³

et al. 2017

Arch Surg Oncol

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“…Because of the dearth of cases, data evaluating the effectiveness of treatment for lung cancer in patients figure 3 Biopsy 11 . In that study, lung cancer staging was demonstrated to be the factor most determinant for survival in patients less than 45 years of age 11 .…”

Section: Discussionmentioning

confidence: 99%

Metastatic Lung Adenocarcinoma in a 20-Year-Old Patient

2010

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Lung cancer is rare disease in patients under 25 years of age. It typically occurs in older patients with a history of tobacco use. This case concerns a 20-year-old man with no history of tobacco use who complained of several months of cough and lower back pain and an 11.3-kg weight loss. He was treated for pneumonia after a chest radiograph showed total opacification of the right lung. Computed tomography imaging subsequently revealed a superior right hilar mass and mediastinal lymphadenopathy. Further imaging studies showed diffuse metastatic disease. Mediastinal biopsy showed poorly differentiated epithelioid tumour with desmoplastic stromal reaction, neutrophil infiltration, and squamous differentiation. Tissue immunostaining confirmed a non-small-cell lung cancer. Unfortunately, despite aggressive therapy, the patient's disease progressed, and he died within 9 months. In this paper, we hope to illustrate the unique challenges in diagnosing and treating young patients with metastatic lung cancer. KEY WORDSMetastatic lung cancer, non-small-cell lung cancer, young patients

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“…Consistent with our data (Table 2), it has been reported that younger patients with lung cancer typically present with an advanced stage, and have relatively short survival times (5-7). Some investi- gators have suggested that the lower occurrence of early-stage disease in younger patients may be due to an intrinsically more aggressive disease (8,9), whereas others have attributed it to the delayed diagnosis that results from a low degree of suspicion of cancer in younger patients (3,4,10). Recently, Ramalingamet al have reported that lung cancer is not an aggressive disease in younger patients, all patients should be treated according to the same therapeutic guideline (2).…”

Section: Discussionmentioning

confidence: 99%

Very Young Patient with Peculiar Squamous Cell Carcinoma of the Lung.

et al. 1999

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A 20-year-old man with squamous cell carcinoma of the lung is described. Histology of the open lung biopsy specimen revealed squamous cell carcinoma with definite keratinization. Interestingly, the tumor cells were characterized by partial expression of CD34antigen and neuroendocrine differentiation.The diagnosis was delayed in this case because of his young age. This delayed diagnosis resulted in rapid progression and short survival time. In our review of 667 cases of lung cancers at Okayama University Hospital, only 3 (0.4%) of them were under 30 years of age and also showed advanced stage and very poor prognosis. It is important to take note of lung cancer as a differential diagnosis to detect early-stage lung cancer in young patients when they present with abnormal shadow on chest radiograph. (Internal Medicine 38: 979-983, 1999)

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Lung Cancer in Young Adults

Cited by 96 publications

References 22 publications

Metastatic Adenocarcinoma in the Young Adult

Metastatic Adenocarcinoma in the Young Adult

Metastatic Lung Adenocarcinoma in a 20-Year-Old Patient

Very Young Patient with Peculiar Squamous Cell Carcinoma of the Lung.

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