Lung cancer: Presentation and pattern of care in a cancer center in South India

Nair, CKrishnan; Mathew, Arun Peter; George, P.S.

doi:10.4103/ijc.ijc_56_17

Cited by 10 publications

(6 citation statements)

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“…Adenocarcinoma was also more common in the age group of 61-80 (55.81%) followed by 41-60 age group (33.72%) Table 6. DISCUSSION: In the present study, a male to female ratio of 4.8:1 was observed and another study from RCC Trivandrum, Kerala was also found the similar male to female ratio of 4.7:1 11 . The sex ratio reported in several Indian studies ranged from 4.5:1 to 8.2:1 21,22 .…”

Section: Exclusion Criteriasupporting

confidence: 85%

“…There are studies which reported adenocarcinoma was the most frequent histological type of lung malignancy 25,37 . A study conducted at RCC Trivandrum, Kerala found that adenocarcinoma (28.5%) was the most common histology type followed by Squamous cell carcinoma (12.9%) 11 . However, the pattern seen at our study district was different and squamous cell carcinoma (48.74%) was still the most frequent, followed by adenocarcinoma (36.13%).…”

Section: Exclusion Criteriamentioning

confidence: 99%

“…Of the 11.3% of new lung cancer cases reported in India, the incidence is more frequent in men and this represents up to 13.7% of the total cancer deaths 10 . In Kerala, in 2013, according to hospital based cancer registries (HBCRs) of Trivandrum RCC reported that lung cancer (15%) was the most common cancer among males 11 . The main trigger for developing lung cancer is use of tobacco.…”

Section: Introductionmentioning

confidence: 99%

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2018

IJPSR

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Background: Lung Cancer is the commonly diagnosed neoplasm in males in India. The main histological types of lung cancer are squamous cell carcinoma, adenocarcinoma, small cell carcinoma and large cell carcinoma. However, histological types may vary with the changes in geographical region, smoking status and other social factors. This study aimed to find out the relationship of smoking and histological types of lung cancer. Methods: We performed a prospective observational analysis of 238 histopathologically proven cases of lung cancer in Malappuram district of Kerala during the period of 2017 and 2018. Results: A total of 238 patients involved, 82.77% were males and the male to female ratio was 4.8:1. Of the 238 patients, 166 patients (69.75%) had history of smoking in their life time and 72 patients (30.25%) were non-smokers. In males, majority of patients were smokers (83.25%) and in female patients, 39 (95.12%) were non-smokers. Among Smokers, squamous cell carcinoma (63.25%) is the most common histological type followed by adenocarcinoma (22.89%). In case of nonsmokers, the status is entirely different and here adenocarcinoma is the most common type and which constitute 66.67% and the presence of squamous cell carcinoma in non-smokers is very less and only 15.27%. Conclusion: In male smokers, squamous cell carcinoma is still the most frequent histological type of lung carcinoma in our study area. In case of females and non-smokers adenocarcinoma is the predominant histological type.

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Section: Exclusion Criteriasupporting

confidence: 85%

Section: Exclusion Criteriamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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2018

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“…4 Despite considerable advancements in diagnosis and treatment, 5-year overall survival (OS) of LC patients remains below 15%. 5,6 Hence, prognostic markers and potential drug targets should be identified to enhance prognosis and individualized treatments.…”

Section: Introductionmentioning

confidence: 99%

CDK1 serves as a potential prognostic biomarker and target for lung cancer

Zhang

et al. 2020

J Int Med Res

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Objective: Evidence from cell and mouse models and human tissues suggests that cyclin dependent kinase 1 (CDK1) is involved in lung cancer (LC) tumorigenesis. However, the different types of expression patterns and prognostic results of CDK1 need further analysis.Methods: In the current study, we assessed CDK1 expression and LC patient outcomes using data from the Oncomine, GEPIA, and Kaplan-Meier Plotter databases. Additionally, mutations in the CDK1 gene were analyzed by using the cBioPortal database. The expression of CDK1 was verified by real-time quantitative PCR using the Human Protein Atlas database and human tissues. Results: Expression of CDK1 was higher in lung adenocarcinoma and squamous cell lung carcinoma tissues than in normal lung samples. Moreover, CDK1 expression was linked to disease progression. Survival analysis indicated that upregulation of CDK1 was related to poor overall survival, low first progression, and post-progression survival in patients with LC. Conclusions: Our results indicate that CDK1 is a potential clinical target and prognostic biomarker for patients with LC.

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“…El rendimiento de la biopsia endobronquial es mayor para lesiones exofíticas visibles por fibrobroncoscopia, con un rendimiento diagnóstico aproximado del 90%. [23][24][25][26] Para los adenocarcinomas la tasa diagnóstica es del 52.6% y para los carcinomas de célula escamosa del 92%. 18 Dentro de los casos con fibrobroncoscopia negativa para lesión tumoral y con histopatología positiva (n = 22) (tabla 2), llama la atención los 4 casos de linfoma (1 caso de linfoma Hodgkin clásico tipo esclerosis nodular, 1 caso de linfoma B marginal, 1 caso de linfoma B difuso de alto grado y un caso de linfoma T extranodal NK), donde este hallazgo de ninguna lesión endoscópica o no relacionada con neoplasia se debe a que la infiltración bronquial suele ser submucosa y no sobresale por la vía aérea.…”

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Concordancia diagnóstica entre la broncoscopia y la histopatología en pacientes con neoplasias pulmonares

Araque

Chaves

et al. 2019

NCT Neumología Y Cirugía De Tórax

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Este artículo puede ser consultado en versión completa en: www.medigraphic.com/neumologia RESUMEN. Antecedentes: El cáncer de pulmón es una de las principales causas de muerte a nivel mundial, cuando se descubre generalmente se hace en estadíos avanzados, constituyendo un mal pronóstico. Este último mejora con un diagnóstico temprano y manejo oportuno. El objetivo de este estudio es evaluar la concordancia entre los hallazgos fibrobroncoscópicos e histopatológicos en pacientes con neoplasias pulmonares, y de esta manera conocer si existe la viabilidad de realizar estudios complementarios de inmunohistoquímica o pruebas moleculares a los casos sospechosos de malignidad en la fibrobroncoscopia. Materiales y métodos: Se realizó un estudio de concordancia diagnóstica incluyendo pacientes mayores de 18 años con diagnóstico de neoplasias pulmonares. Se estimó el acuerdo absoluto y el acuerdo más allá del azar mediante el estadístico de concordancia de Kappa de Cohen. Resultados: Se incluyeron en el estudio 369 casos, de los cuales 207 pacientes (56.1%) fueron de sexo masculino. La mediana de la edad fue de 58 años (RIQ 23). La concordancia del diagnóstico fibrobroncoscópico e histopatológico de neoplasia pulmonar fue moderada con un índice de Kappa positivo de 0.605 (IC95% de 0.496-0.715). La tasa de acuerdo fue del 89%. El adenocarcinoma fue el tumor que mostró menor acuerdo entre las dos pruebas. Conclusiones: El presente estudio mostró una concordancia moderada entre los hallazgos fibrobroncoscópicos e histopatológicos. Estos hallazgos confirman que la sospecha en la endoscopia es fundamental para encaminar el diagnóstico y solicitar pruebas preliminares para un adecuado y oportuno estudio histológico.Palabras clave: Neoplasia pulmonar, cáncer, fibrobroncoscopia, biopsia, concordancia diagnóstica. Diagnostic concordance between bronchoscopy and histopathology in patients with pulmonary neoplasmsAbStRACt. background: Lung cancer is one of the leading causes of death worldwide, it is generally discovered in advanced stages, constituting a poor prognosis, which this last one has an improvement with early diagnosis and timely management. The aim of this study is evaluate the concordance between the fibrobronchoscopic and histopathological findings in patients with pulmonary neoplasias, in order to perform complementary studies of immunohistochemistry or molecular tests to suspected cases of malignancy in the fibrobronchoscopic. Materials and methods: A diagnostic agreement study was carried out, including patients older than 18 years with a diagnosis of pulmonary neoplasms. Absolute agreement and agreement beyond chance were estimated using Cohen's Kappa concordance statistic. Results: 369 cases were included in the study, of which 207 patients (56.1%) were male. The median of age was 58 years (IQR 23). The concordance of the fibrobronchoscopic and histopathological diagnosis of pulmonary neoplasia was moderate with a positive Kappa index of 0.605 (95% CI of 0.496-0.715). The agreement rate was 89%. The adenocarcinoma w...

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Lung cancer: Presentation and pattern of care in a cancer center in South India

Cited by 10 publications

References 14 publications

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CDK1 serves as a potential prognostic biomarker and target for lung cancer

Concordancia diagnóstica entre la broncoscopia y la histopatología en pacientes con neoplasias pulmonares

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